Showing 101–125 of 200 documents
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Susanna Esposito, Beatrice Rita Campana, Gaia Giorgia Arnesano, Nicola Principi
Tuberculosis (TB) remains a leading cause of morbidity and mortality worldwide, with children representing a particularly vulnerable population in whom diagnosis is often challenging. Pediatric TB is typically paucibacillary and presents with non-specific clinical manifestations,…
Marco Polo Peralta Álvarez, Julia L. Marshall, Rachel Tanner
Abstract Multiple immunological mechanisms interact to protect against Mycobacterium tuberculosis ( M.tb ) infection and/or tuberculosis (TB) disease. However, development of a much-needed new and effective TB vaccine is hindered by the lack of validated correlates of protection.…
Lucía Madero, Iria Bastón, Eduard Brunet-Mas, Margalida Calafat, Grupo Joven de GETECCU
Inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, carries an increased risk of tuberculosis (TB), particularly in patients treated with immunosuppressive therapies such as anti-TNF agents. The risk is further elevated when combined with immu…
Bonnie Mallard, Mehdi Emam, S. Cartwright, Tess Altvater-Hughes, Alexandra Livernois, et al.
From the beginning, cattle have made important contributions to the field of immunology, including the development of the first Mycobacterium bovis BCG vaccine for human tuberculosis in 1921. In 1981 the first report of a biosynthesized polypeptide vaccine against Foot and Mouth …
Krista E van Meijgaarden, Patricia S Grace, Natalia T Freund, Jacqueline M Achkar, Thomas Lindenstrøm, et al.
The human immune system employs both innate and adaptive mechanisms to control pathogens, with antibodies playing a pivotal role in immune memory and defense, in particular against viral infections. In tuberculosis, antibody titers have long been used to assess immune responses, …
Kenneth W Foreman, Hui-Chen Foreman
Tuberculosis (TB), primarily caused by(Mtb), remains a leading cause of infectious disease mortality worldwide. Global TB control efforts face several hurdles, including the lack of a broadly effective vaccine, limited sensitivity of current diagnostics, particularly for paucibac…
Kudzai Kanhutu, Karin Leder, Beverley‐Ann Biggs
Abstract There is mounting evidence that the mass population movements associated with the current global refugee and asylum seeker crisis have profound infectious diseases consequences. Key contributory factors identified include disruption of health systems building blocks, mal…
Binghua Han, Fang Liu, Jinzhao Long, Jiongjiong Wang, Yange Cui, et al.
Tuberculosis is an infectious disease caused by(), which poses a notable threat to human health. The present review aims to explore the application of humanized mice in the study ofinfections. Due to differences in immune responses between mice and humans, humanized mice with hum…
Vincent J. C. van Winden, Edith N. G. Houben, Miriam Braunstein
…is and physiology to advance the development of new anti-TB vaccines and antibiotics.
Alessandro Stamilla, Deborah Recchia, Giovanni Stelitano, Ludovica Maci, Maria Concetta Marturano, et al.
Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis, is one of the most challenging pathogens due to its complex physiology, diverse clinical manifestations, and growing multidrug resistance. The global rise of drug-resistant Mtb strains has prompted the searc…
Somashree Mishra, Devshmita Das, Kamakshi Sureka
Cyclic dinucleotides (CDNs), particularly cyclic di-AMP (c-di-AMP) and cyclic di-GMP (c-di-GMP), are now recognised as major second messengers that governs critical physiological and pathogenic processes in Mycobacterium tuberculosis. Beyond their central roles in cell wall homeo…
Min Li, Qiao Zhang, Yun Wang, Jianping Xie, Tian Liang, et al.
Tuberculosis (TB) is caused by, which poses a significant threat to human health. Lipoproteins are predominantly found in thecell wall during infection of the invading host. The cell wall interacts closely with the host cell in direct contact. Thegenome encodes at least 99 lipopr…
Romina Campos-Povea, Enrique González-Madrid, Tays Troncoso-Bravo, Hernán F Peñaloza, Pablo A González, et al.
Allergic asthma is a chronic respiratory disorder driven by a T helper type 2 (Th2)-mediated immune response that involves eosinophils and mast cell recruitment to affected tissues, eliciting inflammatory cytokines and IgE production. Typical symptoms in more severe cases include…
Haoyan Yang, Yinuo Ma, Xinkui Lei, Siyu Chai, Sigen Zhang, et al.
…therapies and support the development of next-generation TB vaccines and treatments.
Mareike Rabe, Jennifer A Hughes
Tuberculosis (TB), particularly drug-resistant TB (DR-TB), remains a major public health concern in South Africa (SA), with children, adolescents, and pregnant and postpartum women (CAPPW) facing heightened risks because of biological and social vulnerabilities. This article high…
Huoming Li, Hao Li
…n against TB, identifying correlates of immunity, and novel vaccines development.
Huilin Fang, Yan Xiong, Beibei Fu, Haibo Wu
Tuberculosis (TB) is an airborne infectious disease caused by the Mycobacterium tuberculosis (Mtb) complex organism. Alveolar macrophages (AMs) play key roles in immune defense, antigen presentation, immune regulation, and immune secretion during Mtb infection. Notably, AMs exhib…
Xinxin Fan, Muxing Chen, Di Wu, Youfei Lin, Xiaohong Chen
…munotherapy have shown promising results. Novel therapeutic vaccines like M72/AS01E demonstrate 54% efficacy in preventing pulmonary TB, while host-directed therapies including nano-based drug delivery systems offer enhanced treatment outcomes. The immune system plays a vital rol…
Parissa Farnia, Ali Akbar Velayati, Jalaledin Ghanavi, Poopak Farnia
Recent large-scale proteogenomic analyses of Mycobacterium tuberculosis (Mtb) have significantly deepened our understanding of its proteome by delineating two major classes of proteins: canonical proteins and microproteins. Canonical proteins, encoded by well-annotated open readi…
Parissa Farnia, Ali Akbar Velayati, Jalaledin Ghanavi, Poopak Farnia
… the development of novel antituberculosis therapeutics and vaccines, as they represent promising targets for disrupting the protective barrier of Mtb.
Parissa Farnia, Ali Akbar Velayati, Jalaledin Ghanavi, Poopak Farnia
… the development of innovative diagnostics, next-generation vaccines, and targeted therapeutics, ultimately advancing more effective strategies for tuberculosis control and eradication.
Parissa Farnia, Ali Akbar Velayati, Jalaledin Ghanavi, Poopak Farnia
Comprehensive strategies for detecting and analyzing proteins in Mycobacterium tuberculosis (Mtb) integrate advanced experimental and computational approaches to deepen understanding of the bacterium's biology, pathogenesis, and mechanisms of drug resistance. Recent technological…
Parissa Farnia, Ali Akbar Velayati, Jalaledin Ghanavi, Poopak Farnia
…ng years of progress. Despite the availability of effective vaccines and treatment regimens, gaps in awareness, funding, healthcare infrastructure, and social determinants of health hinder global elimination efforts. Coordinated, multisectoral strategies are essential to address …
Salvatore Rotundo, Francesca Serapide, Gabriella d'Ettorre, Maria Teresa Tassone, Mattia Albanese, et al.
Tuberculosis (TB) remains a significant global health challenge, especially in countries with low TB incidence, exacerbated by the influx of migrants from high TB-burden regions. This paper reviews the challenges and strategies for managing TB infection (TBI) among migrants. Chal…
Marta Alberti, Riccardo Miggiano
…t is therefore imperative that new antitubercular drugs and vaccines are developed. The peculiar traits of MTB, such as the biochemical and structural features of vital metabolic pathways, can be assessed to identify possible targets for drug development. Enzymes involved in pyri…