Showing 101–125 of 184 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Bianca Sossen, Mmamapudi Kubjane, Graeme Meintjes
… and management of HIV-TB. Antiretroviral therapy and novel regimens for TB preventive therapy are now known to decrease TB incidence and improve survival. The use of Xpert Ultra (Cepheid, USA) and urine DetermineTB LAM Antigen (Abbott, USA) as diagnostics are associated with imp…
Julie Huynh, Yara-Natalie Abo, Rina Triasih, Varinder Singh, Gordon Pukai, et al.
… more accessible TB management aids, shorter effective drug regimens, child-friendly drug formulations, strategies for active case finding to expand treatment coverage including of asymptomatic disease, and more options for preventive therapy. These advances have informed global …
Andrew R DiNardo, Wilbert Sabiiti, Stephen H Gillespie, Sophia B Georghiou, Norbert Heinrich, et al.
…s drug trials are primarily designed to identify antibiotic regimens with the strongest potency to kill. However, microbiologic cure is not synonymous with improved health and recovery. Beyond antimicrobial efficacy, parameters such as morbidity and mortality related to lung func…
David G Russell, Nelson V Simwela, Joshua T Mattila, JoAnne Flynn, Henry C Mwandumba, et al.
…herapeutic routes, could help to optimize vaccines and drug regimens for tuberculosis.
Summaya Perveen, Sunny Pal, Rashmi Sharma
…hemical entities with the potential for effective treatment regimens.
Kerry L Hilligan, Patricia A Darrah, Robert A Seder, Alan Sher
…ne in continuous use. While current intradermal vaccination regimens confer limited protection outside the context of pediatric extrapulmonary tuberculosis (TB), promising new data indicate that when administered mucosally or intravenously at a higher dose, BCG can induce sterili…
Chiwook Chung
Thecomplex (MAC), comprisingand, constitutes the predominant cause of nontuberculous mycobacterial pulmonary disease (NTM-PD) in Korea, followed by thecomplex. Its global prevalence is increasing, as shown by a marked rise in Korea from 11.4 to 56.7 per 100,000 individuals betwee…
Hannah M Gunter, Phuti Choshi, Tafadzwa Chimbetete, Sarah Pedretti, Rannakoe J Lehloenya, et al.
…ent, the use of pharmacogenetic testing to optimize complex regimens and avoid ADRs is appealing, but there has been minimal implementation. To improve the use of pharmacogenetics, understanding both the pharmacology of relevant drugs and population-specific pathophysiology of AD…
Amitesh Gupta, Eshutosh Chandra, Parul Mrigpuri
…ategies for TB-DM management involve tailored anti-diabetic regimens and cautious selection of anti-TB medications to avoid adverse interactions. Insulin is the preferred treatment for severe cases of diabetes in TB patients due to its anabolic properties and lack of interaction …
Pedro Stringelli-Brandão, Marília Prior Fuga, Márcio Ketner Sguassábia, Laura Menezes, Luana Castro, et al.
…loss for several months. He had received several antibiotic regimens without a clinical response. An acid-fast bacilli test and polymerase chain reaction test from an ear secretion confirmed the diagnosis. Despite its rare occurrence, this case is very similar to others reported …
Binghua Han, Fang Liu, Jinzhao Long, Jiongjiong Wang, Yange Cui, et al.
…accelerate the screening of vaccine candidates, therapeutic regimens and the 'bench to bedside' translation process. New therapies, such as IgG1 P1AM25 in humanized Fcγ receptor mice and phage DS6A in humanized NOD.Cg‑PrkdcIl2rgTg(cytomegalovirus‑interleukin&#…
Andrea Migliorelli, Marianna Manuelli, Andrea Ciorba, Francesco Stomeo, Stefano Pelucchi, et al.
…tion from cancer and other inflammatory diseases. Treatment regimens generally consist of standard anti-TB medications, though residual vocal impairment can persist, necessitating speech therapy or surgical intervention.
Gordon Wells, Chaima Hkimi, Lyndon Zass, Judit Kumuthini
…ican population. This approach involves tailoring treatment regimens based on various factors, including drug susceptibility, comorbidities such as HIV, and host genetics. Precision medicine offers a promising avenue for personalised and targeted interventions, aiming to optimise…
Meenakshi Jain, Himanshu Sharma, Menka, Tushar Dash, Rehan Hamdulay, et al.
…stant and MDR-TB, and pretomanid, integrated into multidrug regimens for extensively drug-resistant and MDR-TB, signify critical milestones in addressing drug-resistant TB. These advances are aligned with the global endeavor to achieve TB-related Sustainable Development Goals by …
Vivek P. Chavda, Keshava Jetha, Nimeet Desai, Praful D. Bharadia, Lalitkumar K. Vora
…thms utilize patient-specific data to personalize treatment regimens and forecast responses, optimizing outcomes. In addition to aiding individual patient care, AI-driven surveillance systems play a vital role in tracking TB epidemiology, including the emergence of drug-resistant…
S. S Savale, Rudri Khatri
…erties of these drugs is crucial for optimizing therapeutic regimens, ensuring adequate drug exposure, and minimizing the risk of adverse effects. Factors influencing drug PKs, such as patient characteristics, drug interactions, and disease severity, are also discussed. Moreover,…
Krupanshi Bharadava, Aviral Kaushik, Nigam Vyas, Tarun Kumar Upadhyay, C. Ratna Prabha, et al.
…is disease have led to the development of various treatment regimens, and research in TB drug discovery continues to be a crucial area of study. Identifying the new drug targets is essential in the fight against MDR TB, TDR TB, and XDR TB. Owing to the current situation, the key …
B. S. Das, Gargi Balabantaray, Ashirbad Sarangi, Pradeepta Sekhar Patro, Debapriya Bhattacharya
…contagious and potentially fatal disease. Current treatment regimens are often inadequate, leading to a poor quality of life. Moreover, the emergence of new antibiotics has necessitated the need for more effective therapeutic options. As such, research is being conducted around t…
Marcos Henrique Teles Simão de Melo, Luana Bretas dos Santos Leonhardt, Jônatas Ferreira de Sá, Paulo Roberto Dias Bobenrieth
Pericardial tuberculosis is a rare and potentially fatal form of extrapulmonary tuberculosis that poses a diagnostic challenge, especially in endemic regions. This article reviews its clinical, epidemiological, and diagnostic aspects, based on literature published between 2012 an…
Zuber Peermohammed Shaikh
…erformed to simulate clinical outcomes under various dosage regimens.
…s have also been advanced, including new drugs, combination regimens and new molecular diagnostic methods all have promising solutions.However, solutions to the treatment challenges need to be developed to address rapid diagnostics, effective drug delivery, and improved patient a…
…bal public health threat due to its complexity of treatment regimens as well as the widespread resistance to tuberculosis.The rise of MDR-TB, defined as resistance to isoniazid and rifampicin, was alarming, with over 580,000 new cases recorded in 2015 in regions like India and Ch…
…plains the mechanism of resistance, diagnosis and treatment regimens used for drug-resistant tuberculosis.
Surbhi Sharma, Garima Rai, Harshit Devtalla, Pammi Gauba, Shweta Dang
A chronic respiratory condition known as chronic obstructive pulmonary disease (COPD) is represented by continuous obstructions in airflow and lung inflammation. Major causes of COPD include air pollution, extended exposure to irritant chemicals and particles such as cigarette sm…
Jammula Mounika
Tuberculous meningitis recognized as the most devastating manifestation of tuberculosis, contributes to approximately 20% of childhood TB mortality. This case report focuses on a pediatric patient with obstructive hydrocephalus secondary to tubercular meningitis, complicated by p…