Showing 76–100 of 148 documents
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Shinde Sagar I., Kshirsagar Santosh R., Gondake Sandip P., Hangarge Rahul V.
…istant Staphylococcus aureus (MRSA) and multidrug-resistant tuberculosis (MDR-TB). Due to the emergence of resistance, conventional antibiotics are becoming less and less effective, which calls for the creation of new therapeutic medicines. In order to find possible phytocompound…
Jingjing Li, Huxiao Sun, Dzmitry Shcharbin, Serge Mignani, Jean-Pierre Majoral, et al.
Tuberculosis (TB) is a severe respiratory infectious disease caused by(), which puts enormous pressure on public health and economic systems worldwide. Therefore, accurate diagnosis and timely intervention of TB are critical for interrupting disease transmission and reducing mort…
Zankhana Nathavad, Lata Rani, Aleksandrs Gutcaits, Pawan Gupta
…ed drug design used to expedite the drug discovery process. Tuberculosis (TB) is one of the therapeutic areas where the discovery of novel therapeutics—and the use of existing therapeutics—is still challenging due to microbial drug resistance (MDR). SBDD techniques are being util…
Gavin J Churchyard, Susan Swindells, Amita Gupta, N Sarita Shah, Michael Hughes, et al.
Multidrug-resistant tuberculosis (MDR-TB) remains a global health threat and accounts for a quarter of deaths due to antimicrobial resistance. Individuals infected with MDR-TB are at risk of progressing to TB disease. Treatment of drug-resistant TB infection to prevent progressio…
H Manisha Yapa, Emily L-H MacLean, Nicolas A Menzies, Peter J Dodd, Anna Dean, et al.
SUMMARYDrug-resistant tuberculosis (DR-TB) causes substantial morbidity and mortality and has hindered progress toward TB elimination. This slowed progress toward the WHO End TB Strategy's targets was exacerbated by lower TB detection during the COVID-19 pandemic. To inform resea…
Arpit Raj, Vikrant Abbot, Kapil Kumar
…elopment that results in massive challenges in treating TB. Tuberculosis is one of the most common illnesses that kills people by attacking the parenchymal tissues of the lungs. Even the presence of anti-TB approved drugs in market suffering a failure due to evolving bacterial th…
Harsha Avinash Bhute, Avinash N Bhute, Kishor B Waghulde, Bharati P Vasgi, Reshma Sonar, et al.
**BACKGROUND:** Multi-Drug Resistant Tuberculosis (MDR-TB) is a major public health problem around the world, especially in low- and middle-income countries where quick and accurate testing is needed for effective treatment and control. Traditional ways of diagnosing, like cultur…
Mareike Rabe, Jennifer A Hughes
Tuberculosis (TB), particularly drug-resistant TB (DR-TB), remains a major public health concern in South Africa (SA), with children, adolescents, and pregnant and postpartum women (CAPPW) facing heightened risks because of biological and social vulnerabilities. This article high…
Jin Li, Yanmei Wang, Lei He, Luchuan Yang, Tao Tao, et al.
…ination regimens of antibiotics have significantly improved tuberculosis (TB) cure rates, substantial challenges persist in the global effort to end TB. These include poor patient compliance, the emergence of drug-resistant strains due to prolonged treatments, and the persistence…
Shinde Sagar I., Kshirsagar Santosh R., Gondake Sandip P., Hangarge Rahul V.
…istant Staphylococcus aureus (MRSA) and multidrug-resistant tuberculosis (MDR-TB). Due to the emergence of resistance, conventional antibiotics are becoming less and less effective, which calls for the creation of new therapeutic medicines. In order to find possible phytocompound…
Anna Vassall, Yuriy Chechulin, I Raykhert, N Osalenko, MJ van der Werf, et al.
… consequences for health and health systems in Ukraine. The tuberculosis (TB) situation illustrates this. The World Health Organization (WHO) recommended strategy for TB, Directly Observed Treatment Strategy (DOTS), has the potential to provide real improvements in TB services, f…
Shuhao Cheng, Yuqing Wang, Jie Yao, Guodong Cheng, Gengzhi Ye, et al.
Tuberculosis (TB) poses a notable threat to global public health. Conventional antibiotic treatments are hampered by long treatment courses, notable toxicity and rising levels of drug resistance. By contrast, photodynamic therapy (PDT) offers a promising alternative to antibiotic…
Chrispian Mamudi, Purnamawati, Panca Andana, Prayudi Santoso, Lidya Chaidir, et al.
Tuberculosis (TB) remains a leading cause of infectious mortality worldwide, reflecting persistent gaps in diagnosis, risk stratification, and treatment monitoring. Host RNA transcriptomic signatures have emerged as promising tools for capturing dynamic immune responses across th…
Kshitij Agarwal, Adam T Gray, Tudor P Toma, Valentina Luzzi, Lorenzo Corbetta
The management of tuberculosis (TB) presents significant challenges, particularly in the context of multidrug-resistant TB (MDR-TB) and TB-HIV co-infection. Traditional surgical interventions, such as lung resection and pneumothorax induction, have largely been phased out with th…
Sandhya Krishnan Radhakrishnan, Varadharajan Sundaramurthy
(), the causative agent of tuberculosis (TB), is a uniquely successful pathogen due in large part to its complex lipid-rich cell envelope. Comprising nearly 40% of its dry weight,lipids-such as mycolic acids, phthiocerol dimycocerosates (PDIM), trehalose dimycolate (TDM), and sul…
Gregor Nosan, Andreja Cerkvenik Škafar
Tuberculosis (TB) remains a global health challenge, with around 10 million new cases reported annually and multidrug-resistant strains complicating control efforts. Although incidence has declined in many high-income regions, neonatal populations remain vulnerable, underscoring …
Suparna S. De, Shweta D. Gupta, Mariam S. Degani
…tronidazole. With the growing threat of multidrug resistant tuberculosis in the last two decades, and interesting preliminary results obtained for nitro heterocyclics, their potential as antituberculosis agents has been realised relatively recently. Thus, after a gap of several d…
Vivekanandan Kalaiselvan, Shatrunajay Shukla, S. Ramesh Kumar, Nikita Mishra, Pawan Kumar, et al.
…er, the drugs used in second line or multidrug resistant to tuberculosis (TB), namely bedaquiline, reported to cause QT prolongation in electrocardiogram reading as one of the most common ADRs. Therefore, early identification and prevention of ADRs during ATT is essential for pro…
Rafael Laniado-Laborı́n
Globally, tuberculosis is one of the top 10 overall causes of death, the leading cause of death from a single infectious agent, and the principal cause of death among subjects living with human immunodeficiency virus infection. The United Nations and the World Health Organization…
…tibiotic resistance poses a threat to global public health. Tuberculosis therefore continues to progress because of the emergence of multi-drug resistant strains.
Priyadharshini Basavarajpura Vijay, Mrinal Kanti Das, Amar Bahadur, Chirantan Shivaji, Tanvi Dev
…eported. Oral drug provocation (ODP) in multidrug-resistant tuberculosis is challenging because of the paucity of time and the risk of developing secondary drug resistance in the case of interrupted medication. In this paper, we report a case of drug reaction with eosinophilia an…
Rana Abdullah Bin Qamar, Henrique Pereira, Felipe Alckmin-Carvalho
…g review synthesized evidence on the psychosocial burden of tuberculosis (TB) and on evidence-based psychosocial interventions aimed at improving treatment adherence. Specifically, it examined: (a) the most frequent mental health problems associated with TB; (b) the main barriers…
Aneeka Chavda, Mark Gilchrist, Toby Capstick, Christabelle Chen, Onn Min Kon
Multidrug-resistant tuberculosis (MDR-TB) is a global public health threat associated with high mortality and challenging treatment regimens. The UK, like many countries, faces a growing incidence of MDR-TB, with 105 (1.9% of all notified cases) treated as MDR-resistant or rifamp…
Ignacio Monedero-Recuero, Xiaolin Wei, Fabienne Jouberton, Raquel Duarte, María Rodríguez-Ortega, et al.
…pting health systems and hindering the provision of quality tuberculosis (TB) care. Managing drug-resistant TB (DR-TB) in these settings is particularly challenging. War and post-war conditions could potentially amplify resistance. However, evidence on DR-TB in CE-affected countr…
Ndiviwe Mphothulo, Marian Loveday, Hanlie Myburg
**BACKGROUND:** People on drug-resistant tuberculosis (DR-TB) treatment face multiple challenges, which include severe disease and treatment side effects, together with psychosocial and socioeconomic challenges. These challenges impact patients' ability to remain in care and comp…