Showing 76–100 of 184 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Wenlong Qi, Lin Tian, Zhenyu Li, Jianan Xu, Tan Wang
…ne for IPA with attention to drug-drug interactions; TB/NTM regimens require coordination with anticancer therapy, especially where rifamycins interact with TKIs. Vaccination (influenza, pneumococcus, zoster) and antimicrobial stewardship are essential. Future work should validat…
Xiaoya Mao, Xujiao Hu, Jingjing Fang
…g acetaminophen, amoxicillin-clavulanate, anti-tuberculosis regimens, and immune checkpoint inhibitors. We introduce the concept of metabotype-dependent hepatotoxicity, which emphasizes that individual microbial metabolic profiles influence DILI risk. Advances in metagenomics, me…
Zequn Zheng, Yanbin Chen, Jiangfang Lian
…e studies across antimalarials, psychotropics, tuberculosis regimens, opioids, and oncology agents consistently demonstrate stronger exposure-response relations for metabolites than for their parent drugs. Advances in pharmacokinetic-pharmacodynamic modeling, active-moiety concen…
Francis Adu-Amankwaah, Suzzana Dickson Buabeng, Isabella Sanette Agyekum, Ndivhuwo Tshililo, Lucinda Baatjies, et al.
…al for developing integrated diagnostics and safe treatment regimens. This review integrates current evidence on the overlapping pathogenic, immunological and molecular landscapes of TB and lung cancer to identify shared mechanisms, diagnostic dilemmas and therapeutic challenges,…
Kassahun Dires Ayenew, Habtemariam Alekaw Habteweld, Abate Wondesen Tsige, Yihenew Sewale Bizu
**BACKGROUND:** Due to its resistance to common anti-TB drugs, multidrug-resistant tuberculosis (MDR-TB) presents substantial treatment problems. Optimizing therapeutic outcomes requires individualized treatment plans that take into account patient comorbidities, medication susce…
Mohini Agrawal, K Shyamsundar, Keerthana Raghu, Rajiv Raman, L Dhanurekha, et al.
…erapy (ATT) and corticosteroids, although optimal treatment regimens remain a topic of ongoing debate. Emerging challenges in treatment include paradoxical worsening, drug resistance, and corticosteroid dependency. Recent advancements, such as intravitreal anti-VEGF agents, moxif…
Qin Zhang, Jing Guo, Haiying Lei, Qingfen Zhang
…detection and diagnosis, optimized management of medication regimens, provision of adequate nutritional support, rehabilitation-focused care, and psychosocial support. The necessity of regular follow-up and long-term management is emphasized to prevent complications and promote f…
Cesar Augusto Roque-Borda, Subham Kumar Vishwakarma, Oswaldo Julio Ramirez Delgado, Heitor Leocadio de Souza Rodrigues, Laura M D Primo, et al.
…aches are urgently needed to complement or replace existing regimens. Among emerging candidates, antimicrobial peptides (AMPs) stand out as versatile molecules capable of exerting direct antimycobacterial effects while also modulating the host immune response. This review explore…
Kenneth W Foreman, Hui-Chen Foreman
…verse effects associated with prolonged small-molecule drug regimens. The growing prevalence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains further underscores the urgent need for innovative therapeutic strategies. We outline characteristics of next-gen…
Wenzhong Hu, Yun Xu
…biomarkers, the balance of safety and efficacy in treatment regimens, and patient education to promote the optimisation of RA management strategies.
Cristina Ortega-Portas, Alvaro Auñon, Jaime Esteban
…t, resistance patterns, and treatment responses. Antibiotic regimens are often complex, species-specific, and require guidance from susceptibility testing. Therapeutic decisions often rely on expert consensus and extrapolation from pulmonary disease protocols. Surgical interventi…
Ying Wang, Daxing Cao, Guihua Liu
Treatment regimens for Tuberculosis (TB) primarily rely on first-line drugs such as isoniazid, rifampicin, ethambutol, and pyrazinamide. Although these drugs have been pivotal in the treatment of drug-resistant tuberculosis, their high costs limit widespread use in low- and middl…
Jianfei Zhang, Du Zhang, Kaixi Tan, Bin Jiang
**RATIONALE:** Polyacrylamide hydrogel (PAAG) injection for breast augmentation is linked to long-term complications like inflammation and infection, with bacterial infections being well-documented. However, mycobacterial infections following such procedures are extremely rare, m…
Luana Layse Câmara de Almeida, Sayoane Pessoa Fernandes, Genil Dantas de Oliveira, Marcelly da Silveira Silva, Thalisson Amorim de Souza, et al.
…progress for new drug candidates, drug repurposing, and new regimens, there is still an urgent need for the new medicins to treat TB, especially due to the growing cases of multidrug and extensively drug-resistant (MDR/XDR) strains. Drug resistance is a challenging obstacle to TB…
Jonny Peter, Helen Hoenck, Rannakoe Lehloenya
…nterruption have driven interest in the use of shortened TB regimens, sequential additive drug challenge (SADC) with stat dose intravenous corticosteroids to limit positive drug challenge morbidity, and even desensitization protocols. Although not yet widely adopted, these strate…
J Boffa, D Vambe, C Khosa, B José, N Ndjeka, et al.
…ersal testing, and shorter drug-resistant and paediatric TB regimens. We also identify the key challenges, such as inconsistent drug access, increasing drug resistance and limited healthcare capacity, which continue to affect progress. Health systems must also balance TB care wit…
Muhammad Azhari, Novi Merliani, Marlia Singgih, Masayoshi Arai, Elin Julianti
Tuberculosis (TB) poses a persistent global health threat exacerbated by the emergence of drug-resistant strains; hence, there is a continuous quest for novel antimicrobial agents. Despite efforts to develop effective therapies, existing treatments require a relatively long durat…
Ulan Kozhamkulov, Sholpan Iglikova, Anar Rakisheva, Joseph Almazan
…he implementation of early diagnosis and all-oral treatment regimens has improved adherence in recent studies.
Sarman Singh, Arti Shrivas
… rifampicin resistance detection. Newer drugs and treatment regimens have been introduced and vaccines are in the pipeline. Despite these advances and opportunities, a precise, affordable, and accessible diagnostic model is yet to be evolved, especially in rural and difficult-to-…
Sarah Schmidiger, Damien Portevin
…ectious agent. Improved vaccines, diagnostics and treatment regimens for drug-susceptible and drug-resistant cases are paramount to attain the goals of the WHO's End TB Strategy. Our knowledge gap in protective immunity in TB impedes the development of such new vaccines and host-…
Akhmad Imron, Yulius Hermanto, Ahmad Rizal, Vycke Yunivita, Rovina Ruslami
**BACKGROUND:** Tuberculous meningitis (TBM) is the most common central nervous system infection of(). The infection will cause focal neurological deficits and can be fatal, so that it will increase the morbidity and mortality rates. Adequate treatment is needed so that the drug …
Pooja Semwal, Manjit Kaur Saini, Moinak Sen Sarma
…discontinuing hepatotoxic drugs, initiating non-hepatotoxic regimens, and sequential reintroduction of ATT under close monitoring. For children with ALF, care in a tertiary center with liver transplantation expertise is essential. While pediatric ATDIH generally has favorable out…
Véronique A Dartois, Valerie Mizrahi, Radojka M Savic, Jared A Silverman, David Hermann, et al.
In the absence of effective patient-stratification approaches, tuberculosis (TB) treatment relies on overtreating most patients to ensure high cure rates. Shortening treatment duration without compromising efficacy is therefore high on the agenda of the global TB community. While…
Nnamdi Ikemefuna Okafor, Precious Nnaji, Ngozi Francisca Nnolum-Orji, Yahya E Choonara
Tuberculosis (TB) is considered a major infectious disease by the World Health Organization. The WHO estimates that there are 1.8 million TB deaths, and 10.4 million new cases of the disease reported yearly. While there are conventional therapies for TB, they have drawbacks such …
Steven G Smith, Ruth Bowness, Jacqueline M Cliff
…n should be included specifically in clinical trials of new regimens. In this regard, mathematical modeling has a key role in elucidating which biologic pathways should be targeted in different people. Host-directed therapy for people with tuberculosis-diabetes comorbidity will r…