Showing 26–50 of 148 documents
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Keertan Dheda, Aliasgar Esmail, Anzaan Dippenaar, Robin M. Warren, Jennifer Furin, et al.
…ology, diagnosis, and clinical management of drug-resistant tuberculosis (DR-TB). Tuberculosis (TB) is far from eradicated and remains the foremost single infectious disease killer worldwide. Molecular epidemiology has played an important role in advancing our understanding of DR…
Mange Ram Yadav, Dushyant V. Patel, Divya Teli, Hiral Shah
Tuberculosis (TB) remains a substantial challenge for public health globally, impacting millions of individuals around the world. Despite extensive efforts to control the disease, it continues to pose a major public health challenge, involving therapeutic implications for multi-d…
Komal Saxena, S Shyni Carmel Mary, Prolay Ghosh, Chinnem Rama Mohan, Mohd Naved, et al.
**BACKGROUND:** Tuberculosis (TB) is still the largest cause of death in the world, especially in countries with low and medium incomes. Multi-Drug Resistant Tuberculosis (MDR-TB), which is resistant to isoniazid and rifampicin, is a new type of tuberculosis that makes treatment …
Diah Handayani, Muhammad Faris Indratmo, Ardiana Kusumaningrum, Ahmad Fadhil Ilham, Febriana Catur Iswanti, et al.
Macrophages play a key role in controlling tuberculosis infection. This pilot study aimed to analyze the macrophage profile in drug-resistant tuberculosis patients compared to a group of close contacts diagnosed with latent infection and a group of healthy. The Interferon Gamma R…
Andy Setiawan, Pramudya Pramudya, Hasyrin Ainun
Multidrug-resistant tuberculosis (MDR-TB) represents a strain of TB bacteria that exhibits resistance to a minimum of two primary anti-TB medications: Isoniazid and Rifampicin, both of which are regarded as the most potent drugs for combating TB.The management of drug-resistant T…
Andy Setiawan, Pramudya Pramudya, Hasyrin Ainun
Multidrug resistance tuberculosis (MDR-TB) is a form of tuberculosis bacterial resistance to at least two first-line anti-TB treatments, isoniazid and rifampicin, the two most effective TB medications.Treatment of Drug Resistant TB is set to be part of the national TB Control pro…
Indu Singh, Juhi Sharma, Divakar Sharma, Arun Ratn, Deepa Bisht, et al.
… bedaquiline holds promise for treating multidrug-resistant tuberculosis (MDR-TB). Still, the inflation in bedaquiline resistance has alarmed the global public health crisis, indicating the need for a new treatment strategy. Several scientific studies have reported a high inciden…
James A Seddon, Jay Achar, Amyn A Malik, Jennifer Hughes, Joseph Burzynski, et al.
…ctious multidrug-resistant or rifampicin-resistant (MDR-RR) tuberculosis are at risk of developing tuberculosis disease. Historically, insufficient empirical evidence for preventive treatment in this group has permitted inadequate guidance for clinical decision making. However, s…
Kolimi Prashanth Reddy, Gurdeep Bhatti, Nidhi Singh, Pallab Datta
Current oral therapeutic regime of clofazimine (CFZ) in tuberculosis treatment is limited by poor pharmacokinetics, long t, and especially exposure-related systemic toxicity. This review critically evaluates pulmonary administration as a targeted delivery approach to reduce the d…
Zomer Sardar, Carla Y Kim, Jackson A Roberts, Safia Bano, Kiran T Thakur
…e drug resistance patterns in pulmonary and extra-pulmonary tuberculosis (TB), including central nervous system (CNS)-TB, using the largest reference multidrug resistance laboratory in Punjab, Pakistan. **METHODS:** Retrospective data from 2012 to 2022 were collected from 1410 p…
Risha Hazarika, Sanjukta Patra
…icin resistance continues to pose a challenge to successful tuberculosis (TB) control, mainly driven by mutations in the rpoB gene of Mycobacterium tuberculosis. Although most diagnostic tools, such as Xpert MTB/RIF, Xpert Ultra, and line probe assays, focus on the standard 81-bp…
Gordon Wells, Chaima Hkimi, Lyndon Zass, Judit Kumuthini
Abstract Tuberculosis (TB), caused by Mycobacterium tuberculosis , remains a significant global health challenge, in particular, in the African continent. In 2020, Africa accounted for 25% of new TB cases, with 14 African countries ranking among the top 30 in terms of TB burden. …
Jiaxiang Li, Yilin Liu, Yongdui Ruan, Xinen Kong, Xiaoying Jin, et al.
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a major global public health issue, despite improvements in socioeconomic conditions and widespread use of antibiotics. Host immune defense against Mtb infection involve various cells like macrophages, dendrit…
Jambi Ratna Raja Kumar, Laxmi Bewoor, Kalyani Kadam, Sunil M Sangve, Mayuri B Satpute
Tuberculosis is a disease with many phenotypes, complicated by the hierarchical clinical taxonomies of drug resistance that are not typically leveraged in existing predictive modeling. We developed a taxonomy-driven, hierarchical classification framework trained on a large and di…
Amit Sharma, Poulomi Chatterjee, Shashank Shastry
…oimidazole group of drugs. Drug resistance in Mycobacterium Tuberculosis (MTB) is an ever changing, continuous and evolving process whereby the bacteria finds new genetic mutations to escape destruction by the newer drugs. DLM and PRT belong to the same class of drugs and resista…
Ankush Parmar, Tanzeer Kaur, Shweta Sharma
Tuberculosis (TB) holds a central and deadly platform around the globe, affecting mankind with around one-third of the world being affected by latent TB. TB progresses in the body through inhalation process and has a critical discrimination in terms of affecting individuals depen…
Sarman Singh, Arti Shrivas
Tuberculosis (TB) is still a major health concern. However, each year more than one-third of all global TB cases remain undetected and unreported. On top of that, emergence of drug-resistant TB poses a major challenge. Therefore, a Reliable, Accessible, Cost-Effective, and Easy (…
Rima Zein-Eddine, Masoud Ramuz, Guislaine Refrégier, Johannes F Lutzeyer, Alexey Aleksandrov, et al.
**INTRODUCTION:** Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a major global health concern. It spreads through airborne droplets and has a high mortality rate, particularly without treatment. Drug resistance is rising, with treatments against multidrug…
Nandini Gupta, Ramesh K. Goyal, Bhoomika M. Patel
Tuberculosis (TB) is the 13th leading cause of death worldwide and the second leading cause of death after COVID-19 (above HIV and AIDS). The high rate of morbidity and mortality associated with this disease is due to the presence of multi-drug-resistant bacterial strains of Myco…
Saurabh Gupta, Rasanpreet Kaur, Anshu Upadhyay, Jitendra Singh, Bhuvnesh Prasad Sharma, et al.
Tuberculosis (TB) is a severe disease that causes considerably high morbidity and mortality in low- and middle-income developing nations. The causative agent of TB, Mycobacterium tuberculosis (Mtb), has evolved medication resistance, which has hampered the treatment of TB. The ne…
Jesús Gonzalo‐Asensio, Nacho Aguiló, Dessislava Marinova, Carlos Martı́n
Tuberculosis (TB) is the biggest killer of humanity. TB has killed more human beings than any other infectious disease in history, with an estimated loss of over a billion lives in the past 200 years (1). Despite effective treatment, in the WHO 2016 there were an estimated 10.4 m…
Carlos Acuña-Villaorduña, Anna Vassall, Germán Henostroza, Carlos Seas, Humberto Guerra, et al.
Background: Resistance to commonly used anti-tuberculosis (TB) drugs is emerging worldwide. Conventional drug susceptibility tests (DST) are slow and demanding. Alternative, rapid DST methods would permit the early detection of drug resistance and in turn arrest TB transmission. …
Shweta Tiwari, Ankit Kumar Singh, Aarshu Acharya, Joyabroto Ghosh, Rashmi Prabha Singh
Tuberculosis (TB) accounted for almost 1.2 million deaths in 2024. It remains a leading cause of mortality due to an airborne infectious bacterium, Mycobacterium tuberculosis (MTB). Despite the development of vaccines and antibiotics to cure the disease, it remains a major global…
Parissa Farnia, Ali Akbar Velayati, Jalaledin Ghanavi, Poopak Farnia
Drug resistance in Mycobacterium tuberculosis (Mtb) is a complex phenomenon resulting from multiple coordinated molecular and genetic mechanisms that allow the bacterium to evade antimicrobial agents. Intrinsic resistance primarily stems from the unique architecture of the mycoba…
Jean‐Paul Gaudillière, C Gradmann, A Mcdowell
This chapter discusses two local histories of tuberculosis (TB) to bridge gaps between history and anthropology in global health. Outlining TB’s resurgent interest within the two disciplines from about 1990, the chapter shows that historiographic concern for TB, although limited,…