Showing 1–25 of 42 documents
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Ayushi Sharma, Gyanendra Singh, Rahul Shrivastava
Tuberculosis is a global emergency. Despite two decades of intense research to understand and cure the disease, biological uncertainties prevail and hamper the therapeutic progress. Increasing incidences of multidrug-resistant (MDR) and extensively drug resistant (XDR) Mycobacter…
Vaishnavi Vivekanandan, Arun K, Sindhu Hasini Doredla, Harini Ramanujam, Ranjani Singaraj, et al.
Tuberculosis (TB), caused by members of the Mycobacterium tuberculosis complex (MTBC), remains a significant global health concern. While zoonotic transmission of M. bovis from cattle to humans is well documented, reverse zoonotic transmission of M. tuberculosis from humans to ca…
Kashish Choudhary, Sana Tanweer, Mohd Zaid Choudhary, Sonam Grover
Tuberculosis (TB) is a health concern resulting in 10.8 million cases every year. In 2024, TB had the highest fatalities second only to COVID-19. Global TB management has become difficult due to rise of multi-drug resistant (MDR) and extensively drug-resistant (XDR) TB. Therefore…
Francesca Saluzzo, Andrea Maurizio Cabibbe, Richard Anthony, Alexandra Aubry, Francis Drobniewski, et al.
…rted poor treatment outcomes for extensively drug-resistant tuberculosis (TB) in the European region highlight the urgent need for effective and context-appropriate diagnostic strategies. While the World Health Organisation (WHO) provides model algorithms, these require adaptatio…
Jingxian Ning, Rong Wang, Yuchen Pan, Xinru Fei, Wenxin Jiang, et al.
**OBJECTIVE:** Tuberculosis significantly affects human health and longevity. We aimed to systematically synthesize studies to summarize the median survival time range and years of potential life lost (YPLL) among tuberculosis patients. **METHODS:** We searched Web of Science, P…
Pauline Howell, Jonathan Stillo, Anja Reuter, Tendai Nkomo, Carole D Mitnick, et al.
Drug-resistant tuberculosis is entering a new and dangerous phase. Bedaquiline and other newer drugs have transformed drug-resistant tuberculosis treatment, yet resistance to these agents is now being reported across high-burden settings. In some regions, baseline bedaquiline res…
Supriya Mallick, Manish Shankar, Satyadeo Choubey, Arshad Ejazi, Rakesh Kumar, et al.
**BACKGROUND:** Multidrug-resistant tuberculosis continues to be a major threat to mankind and is a major social and economic burden to society. Line probe assay (LPA) is a method for detecting Mycobacterium tuberculosis (MTb) in combination with resistance to rifampicin and ison…
Yang Zhang, Ruiying Wu, Mingrui Sun, Xiaotian Li, Ren Fang, et al.
Tuberculosis, a chronic infectious disease caused bycomplex, has re-emerged as the leading cause of death worldwide as a single infectious agent. The increasing prevalence of multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis poses a severe and growing t…
Ying Wang, Daxing Cao, Guihua Liu
Treatment regimens for Tuberculosis (TB) primarily rely on first-line drugs such as isoniazid, rifampicin, ethambutol, and pyrazinamide. Although these drugs have been pivotal in the treatment of drug-resistant tuberculosis, their high costs limit widespread use in low- and middl…
Anjali Saxena, Summer Bhagra, Shuvayoo Das, Naveen Kaushik, Biswajit Saha
…drug-resistant and extensively drug-resistant strains of M. tuberculosis. The escalating prevalence of multidrug-resistant and extensively drug-resistant strains, compounded by the pathogen's extraordinary capacity to survive within host macrophages and pharmacologically impenetr…
Joséphine Khady Badiane, Zelika Harouna Hamidou, Abdou Padane, Rita Zgheib, Hamadou Oumarou Hama, et al.
… 49 sub-Saharan African countries, which account for 85% of tuberculosis cases in Africa (WHO, 2025), to monitor the genomic dynamics of Mycobacterium tuberculosis complex strains responsible for the disease was examined for the period 2000-2025. A total of 8141 GenBank entries, …
Roopendra Kumar, Jagdeep Singh Sohal, Ajay Vir Singh, Devendra Singh Chauhan
… nonresponsive multidrug-resistant (MDR) cases of pulmonary tuberculosis (TB). It offers new hope in the global fight against drug-resistant TB, which remains a major health challenge. However, the pursuit of better treatment outcomes has been confronted by the rapid emergence of…
Pulak Pritam, Sreelipta Das, Sandeep Kumar Behera, Monali Sahoo, Lopamudra Subudhi, et al.
The disease tuberculosis, caused by, is one of the leading causes of global human mortality. The rise of multidrug and extensively drug-resistant strains of the pathogen and the limited efficacy of the BCG vaccine is one of the major concerns worldwide. Conventional chemotherapy …
Koushik Mukherjee, Pritam Saha, Kirat Kumar Ganguly, Somjyoti Chakraborty, Swarnali Ghosh, et al.
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a global health threat. Despite advances in diagnostics and treatment regimens, it infects millions annually. It remains a significant global health challenge, particularly due to the appearance of resistance towar…
Agata Maciejak-Jastrzębska, Grażyna Sygitowicz, Sylwia Brzezińska, Kinga Bielska, Ewa Augustynowicz-Kopeć
Tuberculosis (TB), caused by, remains a global health problem. One of the characteristic features of mycobacteria is their exceptional resistance to environmental factors and their slow growth rate, both of which significantly prolong microbiological diagnostics. Due to the morta…
Maciej Michalik, Tomasz Lorenc, Krzysztof Marcinkowski, Mateusz Muras, Natalia Mikszta, et al.
Drug-resistant tuberculosis (DR-TB) poses a significant global health threat, particularly in low- and middle-income countries with limited access to quality healthcare. By 2023, 10% of global tuberculosis cases were classified as drug-resistant, with multidrug-resistant (MDR-TB)…
Anita Saibannavar, Gurjeet Kaur, Nitin Kumbhar
**INTRODUCTION:** Drug resistant Tuberculosis (DR-TB) continues to be a major concern for public health, particularly in countries like India with high disease burden. Recognizing resistance trends and appropriate therapeutic approach is critical for improving patient outcomes an…
Sunil Bajeja, Kandula Jayapaul, Poonam Gaur, Chinnem Rama Mohan, Abhinav Pathak, et al.
**BACKGROUND:** The bacteria Mycobacterium tuberculosis (MTB) cause tuberculosis (TB), which is still a major public health problem around the world. This is especially true now that drug-resistant forms of TB like Multi-Drug Resistant (MDR) and Extensively Drug-Resistant (XDR) a…
Nazia Ahmad, Zeyaul Islam, Sohan Dhar, Pankaj Kumar, Rana Zaidi
Tuberculosis (TB), caused by the infectious agent Mycobacterium tuberculosis (Mtb), has resulted in the highest mortality rates, even surpassing HIV/AIDS. The rise of Drug-resistant TB has worsened the health crisis and urgently requires new treatment approaches. The WHO has appr…
Xinen Kong, Jiayi Yang, Jiajun Wang, Jiaxiang Li, Xiaoying Jin, et al.
Tuberculosis (TB), a chronic zoonotic infectious disease caused by Mycobacterium tuberculosis (Mtb) infection, remains a major public health burden worldwide. The increasing threatens of multidrug-resistant/extensively drug-resistant TB, human immunodeficiency virus (HIV) co-infe…
Parissa Farnia, Ali Akbar Velayati, Jalaledin Ghanavi, Poopak Farnia
Tuberculosis (TB) remains one of the world's most urgent public health challenges, with a substantial global burden that continues to affect millions annually. According to the World Health Organization (WHO) Global Tuberculosis Report 2024, approximately 10.6 million people deve…
Bidyarani Devi Konjengbam, Heikrujam Nilkanta Meitei, Anupama Pandey, Reena Haobam
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), continues to be a major health problem globally. The emergence of multi-drug-resistant TB and extensively drug-resistant TB has become a severe threat to TB control programs. Currently, the Bacille Calmette-Guerin (BC…
Akriti Gaurav, Saif Hameed, Amit Kumar Singh, Zeeshan Fatima
**BACKGROUND:** Tuberculosis (TB), caused by Mycobacterium tuberculosis, continues to pose a serious global health threat, especially with the rise of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains. Progress in developing new therapeutics relies on preclin…
Xin Mao, Jingkai Wang, Junchi Xu, Ping Xu, Huijie Hu, et al.
Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), remains a major global health threat, compounded by the rise of extensively drug-resistant (XDR) and multidrug-resistant (MDR) strains. This review critically examines the current landscape of laboratory diagnostic me…
Christian S Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins Dos Santos, Jonatas Lobato Duarte, et al.
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a major global health concern, particularly due to the emergence of multidrug-resistant and extensively drug-resistant strains. The persistence and propagation of TB are favored by the pathogen's sophisticated…