Showing 1–25 of 98 documents
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Vidya Mave, Mandar Paradkar, Francesca Conradie, Amita Gupta, Anchalee Avihingsanon, et al.
Over the past 80 years, tuberculosis treatment has evolved with the development of all-oral treatments, which are now given for 4-6 months for drug-sensitive tuberculosis and 6-9 months for drug-resistant tuberculosis. Treatment success is often reduced among people with HIV due …
Md Abdur Rahim, Hoonhee Seo, Indrajeet Barman, Mohammed Solayman Hossain, Md Sarower Hossen Shuvo, et al.
Tuberculosis, primarily caused by, is an airborne lung disease and continues to pose a significant global health threat, resulting in millions of deaths annually. The current treatment for tuberculosis involves a prolonged regimen of antibiotics, which leads to complications such…
Rajeev Ranjan, Venkata Siva Reddy Devireddy
Drug resistant tuberculosis is a major public health concern, since the causative agent Mycobacterium tuberculosis is resistant to the most effective drugs against tuberculosis treatment ie., rifampicin and isoniazid. Globally, it accounts 4.6 percent of the patients with tubercu…
Qiuyue Song, Junlin Liu, Chunhua Wang
Tuberculosis is a severe infectious disease caused by(MTB) infection and poses a serious public health challenge globally. The prevalence of multidrug-resistant MTB in countries with a high burden of tuberculosis has further increased the challenges of tuberculosis prevention and…
Alicia M Gutiérrez-Mauricio, Juan Valentín Trujillo-Paez, Luis Alberto Trejo-Martinez, Bruno Rivas-Santiago, Paola Pérez-García, et al.
Tuberculosis (TB) is a contagious infectious disease caused by the bacillus Mycobacterium tuberculosis (Mtb). It is transmitted through small particles in the air (<5 µm) expelled by active tuberculosis patients; when inhaled by a new host, they can potentially cause …
Anca Ionela Fâcă, Denisa Ioana Udeanu, Andreea Letiția Arsene, Beatrice Mahler, Doina Drăgănescu, et al.
Tuberculosis is an infectious condition caused by, primarily targeting the pulmonary system, with the potential to disseminate to various other organs via the haematogenous pathway, ranking among the top ten causes of global mortality. Tuberculosis remains a serious public health…
Ravindra Kumar Garg
…SE OF REVIEW:** The outcome of central nervous system (CNS) tuberculosis has shown little improvement over several decades, with diagnosis remaining unconfirmed in nearly half of the cases. This review highlights current insights and advancements in the diagnosis and treatment of…
Amitesh Gupta, Eshutosh Chandra, Parul Mrigpuri
The intersection of diabetes mellitus (DM) and tuberculosis (TB) constitutes a significant global health challenge, marked by complex disease interactions with profound clinical and public health consequences. TB, a historically prevalent infectious disease, and DM, a rising non-…
Xiaoying Jin, Jiajun Wang, Yongdui Ruan, Jiaxiang Li, Xinen Kong, et al.
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is one of the most prevalent infectious diseases worldwide. Nitric oxide (NO) is produced by the reaction of arginine and oxygen catalyzed by nitric oxide synthase (NOS) in mammals. Several studies have highlighted the …
Rūta Mereškevičienė, Edvardas Danila
Tuberculosis remains a significant public health challenge globally. The emergence of multidrug-resistant Mycobacterium tuberculosis strains presents one of the biggest hurdles in tuberculosis management. Both first- and second-line tuberculosis drugs are associated with common a…
Thi Mai Nguyen, Emily Lai-Ho MacLean, Xiaomei Zhang, Sophia B Georghiou, Hui Xia, et al.
The paucity of diagnostic tests for isoniazid-resistant tuberculosis is concerning, given its status as the most common form of drug-resistant tuberculosis and a gateway to multidrug-resistant diseases. Molecular drug-susceptibility testing has improved access to timely diagnosis…
Rosella Centis, Lia D'Ambrosio, Giovanni Battista Migliori
Tuberculosis is an airborne infectious disease treated with combination therapeutic regimens. Adherence to long-term antituberculosis therapy is crucial to maintain adequate blood drug level. The emergence and spread of drug-resistantstrains is mainly favored by the inadequate me…
Ming-Rui Sun, Jia-Yin Xing, Xiao-Tian Li, Ren Fang, Yang Zhang, et al.
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB) in humans and animals. Mtb invades the host's lungs via airborne transmission, infecting macrophages and causing TB. In some cases, the infection can spread to other tissues and organs. Despite the avail…
Komal Saxena, S Shyni Carmel Mary, Prolay Ghosh, Chinnem Rama Mohan, Mohd Naved, et al.
**BACKGROUND:** Tuberculosis (TB) is still the largest cause of death in the world, especially in countries with low and medium incomes. Multi-Drug Resistant Tuberculosis (MDR-TB), which is resistant to isoniazid and rifampicin, is a new type of tuberculosis that makes treatment …
Diah Handayani, Muhammad Faris Indratmo, Ardiana Kusumaningrum, Ahmad Fadhil Ilham, Febriana Catur Iswanti, et al.
Macrophages play a key role in controlling tuberculosis infection. This pilot study aimed to analyze the macrophage profile in drug-resistant tuberculosis patients compared to a group of close contacts diagnosed with latent infection and a group of healthy. The Interferon Gamma R…
James A Seddon, Jay Achar, Amyn A Malik, Jennifer Hughes, Joseph Burzynski, et al.
…ctious multidrug-resistant or rifampicin-resistant (MDR-RR) tuberculosis are at risk of developing tuberculosis disease. Historically, insufficient empirical evidence for preventive treatment in this group has permitted inadequate guidance for clinical decision making. However, s…
Indu Singh, Juhi Sharma, Divakar Sharma, Arun Ratn, Deepa Bisht, et al.
… bedaquiline holds promise for treating multidrug-resistant tuberculosis (MDR-TB). Still, the inflation in bedaquiline resistance has alarmed the global public health crisis, indicating the need for a new treatment strategy. Several scientific studies have reported a high inciden…
Kolimi Prashanth Reddy, Gurdeep Bhatti, Nidhi Singh, Pallab Datta
Current oral therapeutic regime of clofazimine (CFZ) in tuberculosis treatment is limited by poor pharmacokinetics, long t, and especially exposure-related systemic toxicity. This review critically evaluates pulmonary administration as a targeted delivery approach to reduce the d…
Zomer Sardar, Carla Y Kim, Jackson A Roberts, Safia Bano, Kiran T Thakur
…e drug resistance patterns in pulmonary and extra-pulmonary tuberculosis (TB), including central nervous system (CNS)-TB, using the largest reference multidrug resistance laboratory in Punjab, Pakistan. **METHODS:** Retrospective data from 2012 to 2022 were collected from 1410 p…
Rima Zein-Eddine, Masoud Ramuz, Guislaine Refrégier, Johannes F Lutzeyer, Alexey Aleksandrov, et al.
**INTRODUCTION:** Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a major global health concern. It spreads through airborne droplets and has a high mortality rate, particularly without treatment. Drug resistance is rising, with treatments against multidrug…
Amit Sharma, Poulomi Chatterjee, Shashank Shastry
…oimidazole group of drugs. Drug resistance in Mycobacterium Tuberculosis (MTB) is an ever changing, continuous and evolving process whereby the bacteria finds new genetic mutations to escape destruction by the newer drugs. DLM and PRT belong to the same class of drugs and resista…
Risha Hazarika, Sanjukta Patra
…icin resistance continues to pose a challenge to successful tuberculosis (TB) control, mainly driven by mutations in the rpoB gene of Mycobacterium tuberculosis. Although most diagnostic tools, such as Xpert MTB/RIF, Xpert Ultra, and line probe assays, focus on the standard 81-bp…
Jambi Ratna Raja Kumar, Laxmi Bewoor, Kalyani Kadam, Sunil M Sangve, Mayuri B Satpute
Tuberculosis is a disease with many phenotypes, complicated by the hierarchical clinical taxonomies of drug resistance that are not typically leveraged in existing predictive modeling. We developed a taxonomy-driven, hierarchical classification framework trained on a large and di…
Jiaxiang Li, Yilin Liu, Yongdui Ruan, Xinen Kong, Xiaoying Jin, et al.
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a major global public health issue, despite improvements in socioeconomic conditions and widespread use of antibiotics. Host immune defense against Mtb infection involve various cells like macrophages, dendrit…
Sarman Singh, Arti Shrivas
Tuberculosis (TB) is still a major health concern. However, each year more than one-third of all global TB cases remain undetected and unreported. On top of that, emergence of drug-resistant TB poses a major challenge. Therefore, a Reliable, Accessible, Cost-Effective, and Easy (…