Showing 1–25 of 200 documents
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Rajeev Ranjan, Venkata Siva Reddy Devireddy
Drug resistant tuberculosis is a major public health concern, since the causative agent Mycobacterium tuberculosis is resistant to the most effective drugs against tuberculosis treatment ie., rifampicin and isoniazid. Globally, it accounts 4.6 percent of the patients with tubercu…
Sunil Bajeja, Kandula Jayapaul, Poonam Gaur, Chinnem Rama Mohan, Abhinav Pathak, et al.
… problem around the world. This is especially true now that drug-resistant forms of TB like Multi-Drug Resistant (MDR) and Extensively Drug-Resistant (XDR) are becoming more common. Traditional ways of diagnosing drug resistance take a lot of time and resources, which means they …
Parikshana Mathur, Pinky Choudhary, Rajkuberan Chandrasekaran, Ragini Singh, Hemant Kumar Daima
…nt even after the global initiatives and emergence of multi-drug resistance (MDR) strains have made the situation complicated. Herein, the exploitation of the same medications for several decades, ineffective drug administration, and insufficient patient follow-up are some of the…
Kara Lukas, Madeleine T Dang, Clare Necas, Vishwanath Venketaraman
…uberculosis (TB) is a global health challenge caused bywith drug resistance, treatment toxicity, and treatment adherence challenges continuing to impede control efforts. The objective of this review is to explore current advancements in TB treatment, for both drug-sensitive and d…
Prashant Wakhare, Shagufta Md S Sheikh, Pragati Mahale, Pritesh Patil, Sanjay Bhilegaonkar, et al.
…mmon infectious disease that kills people around the world. Drug-resistant types like multi-drug resistant (MDR-TB) and widely drug-resistant TB (XDR-TB) are becoming more common, which makes treatment much harder. Molecular tests and trait drug resistance testing are common ways…
Anita Saibannavar, Gurjeet Kaur, Nitin Kumbhar
**INTRODUCTION:** Drug resistant Tuberculosis (DR-TB) continues to be a major concern for public health, particularly in countries like India with high disease burden. Recognizing resistance trends and appropriate therapeutic approach is critical for improving patient outcomes an…
Erfaneh Jafari, Reza Azizian, Mohsen Tabasi, Morteza Banakar, Kamran Bagheri Lankarani
… by, remains a major global health burden. The emergence of drug-resistant strains presents a critical challenge in TB management. The recent research has explored the interaction between TB and the human gut bacteriophage community (phageome). The gut phageome plays a crucial ro…
Shuying Zhang, Juan Cheng, Yuanyuan Tang
Drug-resistant(Mtb) has become a global public health crisis, and its diverse drug resistance jointly reduces the effectiveness of antibacterial drugs. Mtb resistance is not merely genetic but involves a synergistic interplay of cell wall remodeling, metabolic reprogramming, and …
Mehdi Roshdi Maleki
…h due to infectious disease. Additionally, the emergence of drug-resistant strains has created a significant challenge for the treatment of this disease. Approximately 25% of TB-related deaths are attributed to antimicrobial drug resistance. Various mechanisms contribute to the d…
Maciej Michalik, Tomasz Lorenc, Krzysztof Marcinkowski, Mateusz Muras, Natalia Mikszta, et al.
Drug-resistant tuberculosis (DR-TB) poses a significant global health threat, particularly in low- and middle-income countries with limited access to quality healthcare. By 2023, 10% of global tuberculosis cases were classified as drug-resistant, with multidrug-resistant (MDR-TB)…
John W Wilson, Zelalem Temesgen, James T Gaensbauer
…of management updates recently have been published for both drug-susceptible and drug-resistant tuberculosis (TB), TB in children, and contacts of patients with drug-resistant TB. The operationalization and application of these recommendations, which reflect favorable clinical tr…
Carolina H Chung, Rupa Bhowmick, Annie J Badenoch, Harkirat S Arora, Sriram Chandrasekaran
Drug resistance is a major challenge in cancer and infectious diseases, requiring innovative solutions. Recent research suggests that bacteria and cancer cells reprogram their metabolism and manipulate their external metabolic environment to resist a diverse range of therapeutics…
Chiara Sepulcri, Francesca Saluzzo, Daniele Roberto Giacobbe, Antonio Di Biagio, Daniela Maria Cirillo, et al.
**INTRODUCTION:** Drug-resistant tuberculosis (DR-TB) still represents a critical global health threat despite recent therapeutic advances. The shift from long, injectable-based regimens to shorter, all-oral regimens has improved outcomes, yet substantial challenges remain in ens…
Parissa Farnia, Ali Akbar Velayati, Jalaledin Ghanavi, Poopak Farnia
Drug resistance in Mycobacterium tuberculosis (Mtb) is a complex phenomenon resulting from multiple coordinated molecular and genetic mechanisms that allow the bacterium to evade antimicrobial agents. Intrinsic resistance primarily stems from the unique architecture of the mycoba…
Roopendra Kumar, Jagdeep Singh Sohal, Ajay Vir Singh, Devendra Singh Chauhan
…Pretomanid, and Linezolid) regimen for treating extensively drug-resistant (XDR) and treatment-intolerant/ nonresponsive multidrug-resistant (MDR) cases of pulmonary tuberculosis (TB). It offers new hope in the global fight against drug-resistant TB, which remains a major health …
Kashish Choudhary, Sana Tanweer, Mohd Zaid Choudhary, Sonam Grover
…bal TB management has become difficult due to rise of multi-drug resistant (MDR) and extensively drug-resistant (XDR) TB. Therefore, novel approaches must be developed to fight with M.tb infection. Studies on many strategies like pathogen-centric, host-directed therapeutics, anti…
Sabina Gałka
Drug resistance in bacteria and fungi is a global threat to public health. The purpose of this publication is to review the latest scientific achievements, mainly from 2020-2025, concerning the use of hemp compounds from Cannabis sativa in combating drug-resistant bacterial and f…
Alex Odoom, Abdul-Halim Osman, Christian K O Dzuvor
Antimicrobial resistance poses a grave threat to global public health. Although new antibiotics are urgently needed, most share resistance mechanisms with existing drugs, thereby necessitating the development of alternative antibacterial therapeutics. Various immunotherapeutic ag…
Mohammed Alfaqeeh, Prayudi Santoso, Jan-Willem Alffenaar, Ivan S Pradipta
Drug-resistant tuberculosis (DR-TB) continues to be a major global health threat, and while advancements in drug therapies have been made, the role of pharmacists in improving patient outcomes has not been fully optimized. This review aims to describe the types, resistance mechan…
Komal Saxena, S Shyni Carmel Mary, Prolay Ghosh, Chinnem Rama Mohan, Mohd Naved, et al.
… especially in countries with low and medium incomes. Multi-Drug Resistant Tuberculosis (MDR-TB), which is resistant to isoniazid and rifampicin, is a new type of tuberculosis that makes treatment and disease control much harder. Conventional diagnostic methods, like quantitative…
Yashna Sukdeo, Nozibusiso Pearl Shozi, Nonsikelelo Ndimande, Kingsley Chimaeze Mbara, Peter M O Owira
…void the hostile host immune defence systems and also mount resistance to chemotherapy when exposed to antibiotic stress. MTB's epigenetic survival tool-kit includes genomic DNA histone acetylation/deacetylation, methylation, phosphorylation, ubiquitylation, etc. The non-coding h…
Sandeep Rai, Abhishek Sen, Harsh Shah, Jay Patel
The emergence of drug-resistant tuberculosis (DR-TB), especially multi drug resistant tuberculosis (MDR-TB), is increasingly threatening the effectiveness of India's National TB Elimination Program (NTEP). This review seeks to analyse the patient and health system challenges conc…
Zomer Sardar, Carla Y Kim, Jackson A Roberts, Safia Bano, Kiran T Thakur
**BACKGROUND:** This study aims to investigate drug resistance patterns in pulmonary and extra-pulmonary tuberculosis (TB), including central nervous system (CNS)-TB, using the largest reference multidrug resistance laboratory in Punjab, Pakistan. **METHODS:** Retrospective data…
Radha Gopalaswamy, Bhargavi Subramanian, Manisha Parthasarathy, Chandrasekaran Padmapriyadarsini, Sivakumar Shanmugam
Timely detection of drug resistance is a pre-requisite to tuberculosis management globally. While phenotypic drug susceptibility testing (pDST) by liquid or solid method takes time, current genotypic DST assays can be performed directly from clinical specimens but target only a l…
Shweta Tiwari, Ankit Kumar Singh, Aarshu Acharya, Joyabroto Ghosh, Rashmi Prabha Singh
…sis against the human defence system and the development of drugs against MTB, with particular emphasis on the mechanisms of drug resistance and mutations that render them ineffective globally. There is also a discussion of the MTB lineage and the mutant types. The mechanism…