Showing 1–25 of 200 documents
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Rahma Isti Kusyadi, Lita Diah Rahmawati, Prastuti Asta Wulaningrum
**INTRODUCTION:** Poncet's disease (PD) is a rare form of TB-associated reactive arthritis, presents a major diagnostic challenge due to its close resemblance to rheumatoid arthritis and tuberculous septic arthritis. A clear diagnostic workflow is essential to support clinical de…
Jorge E Leiva-Ordoñez, Beatriz Quintero
Tuberculous meningitis is the most severe form of tuberculosis and remains associated with high mortality and substantial neurological disability, particularly among children and people living with HIV. Early diagnosis is challenging because of nonspecific clinical manifestations…
Eduarda Rabello, Fernanda de-Paris
Tuberculosis (TB) remains one of the leading causes of death from a single infectious agent worldwide, a burden further exacerbated by HIV co-infection and the increasing prevalence of drug-resistant strains. Although a wide range of laboratory diagnostic methods are currently av…
Emily A Kendall, Claudia M Denkinger, Adithya Cattamanchi, David W Dowdy, Jason R Andrews
…ponent tests. Therefore, when evaluating novel tuberculosis diagnostics, greater consideration should be given to characterising which segments of the disease spectrum are detected, how these segments overlap across tests, and how they are prioritised for detection. Understanding…
Juan José Villamarín Marrugo, Juan Manuel Naranjo Piñeros, Erwin Hernando Hernandez Rincon
**RATIONALE AND OBJECTIVES:** Access to diagnostic imaging in low- and middle-income countries (LMICs) is limited by scarce equipment, geographic barriers, weak digital infrastructure, and shortages of trained personnel. Artificial intelligence (AI) has emerged as a promising too…
Maria Helena Favarato, Victoria Luisa Pereira Aguiar, Edison Ferreira Paiva, Leonardo Oliveira Mendonça
**BACKGROUND AND METHODS:** Recurrent fever is a complex clinical presentation that poses significant diagnostic challenges, particularly when no clear etiology emerges despite extensive investigation. This integrative narrative review provides a comprehensive overview of recurre…
Derong Kong, Zhenzhen Xu, Chang Chen, Yunqi Liu, Dacheng Wei
…(POC) testing holds great promise for transforming clinical diagnostics by enabling rapid, convenient, and accurate analysis outside of centralized laboratories. Among various emerging technologies, biological field-effect transistors (bio-FETs), which directly convert molecular …
Patrycja Olszewska, Monika Spietelun, Katarzyna Syguła, Andrzej Ossowski, Bartłomiej Grygorcewicz
…fically infect bacteria, have emerged as a valuable tool in diagnostics due to their unique specificity and adaptability. This review explores the diverse applications of bacteriophages in diagnostic methods, from traditional phage typing to advanced molecular techniques such as …
Norbert Georg Schwarz, Ulrike Loderstaedt, Andreas Hahn, Rebecca Hinz, Andreas Erich Zautner, et al.
…uld not preclude developing countries from state of the art diagnostics.
Risha Hazarika, Sanjukta Patra
Rifampicin resistance continues to pose a challenge to successful tuberculosis (TB) control, mainly driven by mutations in the rpoB gene of Mycobacterium tuberculosis. Although most diagnostic tools, such as Xpert MTB/RIF, Xpert Ultra, and line probe assays, focus on the standard…
Yi En Ding, Matthew Tze Jian Wong, Mohd Nor Norazmi, Venugopal Balakrishnan, Gee Jun Tye
…o enhance distinction within the infection timeline in LTBI diagnostics. Advancement in immune profiling, dormancy antigen, along with molecular and transcriptomic approaches holds great promise to develop a diagnostic tools with better accuracy to differentiate recent from remot…
Francesca Saluzzo, Andrea Maurizio Cabibbe, Richard Anthony, Alexandra Aubry, Francis Drobniewski, et al.
The reported poor treatment outcomes for extensively drug-resistant tuberculosis (TB) in the European region highlight the urgent need for effective and context-appropriate diagnostic strategies. While the World Health Organisation (WHO) provides model algorithms, these require a…
Yu Li, Hongjuan Wei, Limei Sun, Dongsong Tang, Tiantian Wang, et al.
…cal diagnostic approaches. Recent advancements in molecular diagnostics have revolutionized tuberculosis detection in this vulnerable population. This review critically evaluates current laboratory methods for MTB detection in HIV/MTB co-infected individuals, analyzing their diag…
Mainak Ghosh, Monali Lahiri, Aman Dalal, Kishan Kumar Parida, Nitin Pal Kalia
… for successful management of the disease. The conventional diagnostics includes staining, microscopy, tuberculin skin test and chest X ray. However, they have various limitations which increases the public threat. These tools lack the ease of transportation, less sensitive, time…
Moustafa Kardjadj
Point-of-care (POC) infectious disease diagnostics are reshaping global health by delivering rapid, decentralized, and clinically actionable results that link bedside testing to population-level surveillance. Valued at approximately USD 53 billion in 2024 and projected to nearly …
Leah Argus, Vijay Sharma, Christopher Darlow, Kavita Sethi, Iain Lyburn, et al.
**AIMS:** Idiopathic granulomatous mastitis (IGM) is a rare, benign inflammatory breast condition of unknown aetiology. It is a diagnosis of exclusion with a wide differential diagnosis. To date, no diagnostic guidelines exist for IGM in the UK. This scoping review aims to evalua…
Cemre Arpa, Ahmed Abd El Wahed, Serap Aydin, Prakash Ghosh, Dinesh Mondal, et al.
…globally. Non-specific symptoms and limitations of existing diagnostics involve challenges for informed policymaking and clinical practice. This paper reviews common practices in reporting the selection and definition of cost and effect parameters, and in reporting the translatio…
Xiao Dong, Chao Xie, Zhe Zhang, Hongjian Ye, Ruihua Liu, et al.
Peritonitis caused by atypical and rare pathogens is challenging to diagnose. Although the International Society for Peritoneal Dialysis (ISPD) guidelines significantly improve the diagnostic rate by placing peritoneal dialysis fluid into blood culture bottles, peritonitis caused…
Qiuyue Song, Junlin Liu, Chunhua Wang
…s future development directions for tuberculosis laboratory diagnostics, aiming to provide valuable methodological references for the clinical diagnosis and treatment of tuberculosis.
Dr Rashmi Dixit, Dr Sonali Garg, Dr Gaurav Shanker Pradhan
Pott's spine is associated with high morbidity, long-term disabling sequelae and even mortality. The classical paradiscal form, where there is destruction of end plates of adjacent 2-3 vertebral bodies along with intervening disc involvement and associated paravertebral abscess i…
Christian Görg, Yi Dong, Görg Friedemann, Christian Jenssen, Michael Kallenbach, et al.
Necrotizing (abscessing) lymphadenopathy is a clinically relevant condition with a broad differential diagnosis, including acute bacterial infections, mycobacterial disease, zoonoses, fungal and parasitic infections, autoimmune disorders, and malignancies with central necrosis. E…
Madeleine T Dang, Kara Lukas, Daniel H Choi, Timothy J Chu, Vishwanath Venketaraman
Extrapulmonary tuberculosis (EPTB) is an infectious disease characterized by the invasion ofbeyond the lungs. Diagnosis is frequently delayed due to nonspecific clinical presentations that vary by organ system, making diagnostic imaging essential for disease detection, characteri…
Karthikeyan Sundaram, Sridhar Rathinam, Venkataraman Prabhu
Tuberculosis and systemic fungal diseases are opportunistic and challenging to diagnose. However, in immunocompromised people, especially people living with human immunodeficiency virus (PLHIV), the signs and symptoms of both diseases highly imitate each other. Primarily, chronic…
Agata Maciejak-Jastrzębska, Grażyna Sygitowicz, Sylwia Brzezińska, Kinga Bielska, Ewa Augustynowicz-Kopeć
…h rate, both of which significantly prolong microbiological diagnostics. Due to the mortality rate and the rising prevalence of multidrug-resistant (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB), early detection and prompt initiation of treatment are extremely impo…
Thi Mai Nguyen, Emily Lai-Ho MacLean, Xiaomei Zhang, Sophia B Georghiou, Hui Xia, et al.
… to select 238 studies published between 2000 and 2024. The diagnostics options have expanded rapidly since 2020, with 27 nucleic acid amplification tests, eight line probe assays, five DNA microarrays, two targeted next-generation sequencing platforms, and two whole-genome seque…