Showing 151–175 of 200 documents
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Parissa Farnia, Ali Akbar Velayati, Jalaledin Ghanavi, Poopak Farnia
Future research on Mycobacterium tuberculosis (Mtb) proteins is essential for advancing tuberculosis (TB) diagnosis, treatment, and control amid rising drug resistance and global health challenges. Recent studies focus on elucidating protein structures and interactions critical t…
Ruqaiyyah Siddiqui, Naveed Ahmed Khan
Mycobacterium tuberculosis remains one of the world's most persistent pathogens, responsible for over a million deaths each year despite effective drugs and decades of research. Disease progression varies widely among individuals, reflecting interactions between pathogen, physiol…
Marco Silva, Alexandre J Pinto, Tiago Beites
…ironment. In this context, the human pathogen Mycobacterium tuberculosis is an interesting example. Despite being an obligate pathogen that has been co-evolving with the human host for millennia, M. tuberculosis genome retains redundant functions at multiple levels that allow the…
Yingxiao Han, Songwei Ma, Rui Ma, Jingjing Li, Lei Qiu, et al.
Mycobacterium tuberculosis culture filtrate proteins (MTB-CFPs) are critical for tuberculosis diagnosis and vaccine development. To explore their diagnostic potential, MTB was statically cultured in Sauton's medium for 15 days; MTB-CFPs were collected, fractionated using six…
Agata Maciejak-Jastrzębska, Grażyna Sygitowicz, Sylwia Brzezińska, Kinga Bielska, Ewa Augustynowicz-Kopeć
Tuberculosis (TB), caused by, remains a global health problem. One of the characteristic features of mycobacteria is their exceptional resistance to environmental factors and their slow growth rate, both of which significantly prolong microbiological diagnostics. Due to the morta…
Manjula Singh, Tahziba Hussain, Bhavesh Modi, Sanjeev Nair, Sunil Kumar, et al.
…ves Only 10% of the individuals infected with Mycobacterium tuberculosis (MTB) manifest active tuberculosis. Interferon-γ release assay (IGRA) and tuberculin skin test using purified protein derivative (PPD) are used to identify tuberculosis (TB) infection. We aimed to stud…
Yuqi Ma, Xiwei Lu, Xu Cao, Xintong Lv, Jiaying Li
The comorbidity of diabetes and tuberculosis (TB) poses a major public health challenge. Patients with diabetes have impaired immune function, increasing their risk of contracting TB. They often present with atypical clinical symptoms after infection, which can lead to delayed di…
Fangzheng Guo, Yamin Song, Sihang Dong, Jing Wei, Baiqing Li, et al.
Tuberculosis (TB) is a chronic infectious disease caused by(Mtb) that poses a severe threat to human health. A variety of highly immunogenic tuberculosis proteins have been used as targets in vaccine development to mitigate the spread of TB. Although Th1-type immunity has long be…
Haiqi Chen, Abulimiti Abudukadier, Qi'ao Zhang, Peibo Li, Jianping Xie
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), constitutes a major global health challenge. The pathogenesis of Mtb can be largely attributed to its sophisticated survival strategies within host macrophages. Methylglyoxal (MGO), a ubiquitous reactive dicarbonyl me…
Mohammad Nasir, Samreen Ahmed, Mohammad Shameem, Kaif Siddiqui, Azmat Karim
The 26.07 lakh reported cases of Tuberculosis (TB) in 2024 render India's target of eradicating TB under the National Tuberculosis Elimination Programme a distant dream. Nonetheless, by leveraging Artificial Intelligence (AI), India can chase the United Nations' 2030 target. A ma…
Abayomi S Faponle, James W Gauld, Sam P de Visser
…l, adaptability and pathogenicity.is the causative agent of tuberculosis, an infectious disease that affects millions of people globally. Common anti-tuberculosis targets are focused on immobilizing a vital cysteine amino acid residue in enzymes that plays critical roles in redox…
Seán Donohue, Gina Leisching, Joseph Keane
Greater understanding of the immunopathogenesis of tuberculosis is critical for developing novel therapies. Here, we propose that immunothrombosis plays an important role in the immune response to Mycobacterium tuberculosis. This interplay among macrophages, neutrophils, and plat…
Meng-Yuan Lyu, Hong-Li Lai, Hao-Ran Peng, Han Luo, Jian Zhou, et al.
The worldwide dissemination of drug-resistant tuberculosis (TB) presents significant obstacles to conventional anti-TB treatment and prevention methods based on bactericidal antimicrobial drugs, greatly impeding advancements in combating this most lethal disease. With growing ins…
Dingyuan Yan, Xue Li, Huanhuan Wang, Bin Li, Wei Wang, et al.
…anoparticle (NP) for precise phototheranostics of pulmonary tuberculosis (TB). Coating the phototheranostic agents with preactivated macrophage membranes results in the formation of biomimetic NPs, which exhibit specific binding to TB through a lesion-pathogen dual-targeting stra…
Cui Bao, Yuanyuan Zhang, Jiao Feng, Xiuwen Hong, Nan Gao, et al.
Tuberculosis is a widely spread disease caused by(Mtb). The pathogenicity of the pathogen is closely associated with the immune defense mechanisms of the host cells. As key cellular degradation and metabolic centers, lysosomes critically regulate tuberculosis infection. When Mtb …
John Dawi, Scarlet Affa, Stefanie Au, Yura Misakyan, Edgar Gonzalez, et al.
…therapy. This redox imbalance is further exacerbated in HIV-tuberculosis co-infection, where compounded inflammatory and metabolic stress increases susceptibility to opportunistic infections and treatment-related complications. This review examines the efficacy and safety of glut…
Kolimi Prashanth Reddy, Gurdeep Bhatti, Nidhi Singh, Pallab Datta
Current oral therapeutic regime of clofazimine (CFZ) in tuberculosis treatment is limited by poor pharmacokinetics, long t, and especially exposure-related systemic toxicity. This review critically evaluates pulmonary administration as a targeted delivery approach to reduce the d…
Cathrin Gramminger, Tilo Biedermann
Tuberculosis (TB) continues to be a leading cause of death in many countries, and also remains a significant concern in Germany, particularly due to migration. The diagnosis of rare cutaneous tuberculosis is challenging as it manifests in various clinical forms that resemble more…
Adrian R Martineau
…f vitamin D supplementation for prevention and treatment of tuberculosis or acute respiratory infections (ARI). It also considers why null results from these studies contrast with largely positive results from laboratory studies, observational epidemiology and early RCTs in the f…
Sonya Krishnan, Robin Avery, Veronica Dioverti, Jeffrey A Tornheim
**PURPOSE OF REVIEW:** Tuberculosis disease (TBD) has high mortality in transplant recipients. This review evaluates the current evidence for latent tuberculosis infection (LTBI) screening and treatment in solid organ transplant (SOT) and hematopoietic stem cell transplant recipi…
Nicoleta Sorina Bertici, Talida Georgiana Cut, Amalia Ridichie, Andrei Raul Manzur, Razvan Adrian Bertici
Tuberculosis and parasitic infections, including, frequently coexist in many regions worldwide, yet their interaction remains poorly understood. Tuberculosis triggers a type 1 immune response characterized by IL-12, IFN-γ, and TNF-α production, while toxocariasis elic…
Sergiu Marian Cazacu, Costin Teodor Streba, Cristian Constantin, Claudiu Marinel Ionele, Ion Rogoveanu, et al.
…s, even in developing countries, whereas that of intestinal tuberculosis has decreased, which places both diseases at an epidemiological crossroads. Crohn's disease and intestinal tuberculosis share many clinical, endoscopic, imaging, and pathological features, which sometimes ma…
Tyagita Hartady, Faisal Amri Satrio, Syahrul Maulana, Dwi Wahyuda Wira, Endang Yuni Setyowati, et al.
Zoonotic tuberculosis (zTB), predominantly caused by, remains an underrecognized public health threat in many low- and middle-income countries. Although global estimates suggest that zTB accounts for approximately 1-1.5% of all human tuberculosis cases, limited molecular diagnost…
Janke Kleynhans, Christiaan A Gouws, Thomas Ebenhan
…ET/CT radiopharmaceuticals can better visualize and monitor tuberculosis and enable real-time pharmacological drug profiling in vivo. PET/CT imaging can therefore be used to study in animal models the changes in tissue pathology in tuberculosis infection, such as mycobacterial la…
Andrew R DiNardo, Wilbert Sabiiti, Stephen H Gillespie, Sophia B Georghiou, Norbert Heinrich, et al.
Tuberculosis drug trials are primarily designed to identify antibiotic regimens with the strongest potency to kill. However, microbiologic cure is not synonymous with improved health and recovery. Beyond antimicrobial efficacy, parameters such as morbidity and mortality related t…