Showing 126–150 of 200 documents
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Pranay Sinha, Madhavi Bhargava, Madeline E Carwile, Madolyn R Dauphinais, Phumeza Tisile, et al.
Undernutrition-the leading risk factor for tuberculosis worldwide-is associated with impaired immunity, more extensive disease, delayed sputum conversion, and worse treatment outcomes, including mortality. In this Health Policy, we propose a comprehensive roadmap for integrating …
Chengzhi Liu, Xinyu Wang, Xusheng Cao
**PURPOSE:** Ocular tuberculosis (OTB), an extrapulmonary manifestation of tuberculosis (TB), significantly impacts vision acuity and presents challenges in diagnosis and treatment. With ongoing research efforts, new insights into its pathogenesis and treatment have emerged. This…
Ahmad Faris Daradkeh, Basil Alawyia, Hassan Ballas, Nikolaos Spernovasilis, Danny Alon-Ellenbogen
Tuberculosis continues to represent a major occupational risk in healthcare environments, particularly for healthcare workers who have persistent contact with patients who may be infectious. Despite the high occupational burden of tuberculosis among healthcare workers, there rema…
John Dawi, Scarlet Affa, Yura Misakyan, Edgar Gonzalez, Stephen Affa, et al.
Tuberculosis and coronavirus disease 2019, also known as COVID-19, remain major global health challenges that disproportionately affect individuals with metabolic disorders, chronic inflammation, and limited access to healthcare. Although these diseases are caused by different pa…
Pulak Pritam, Sreelipta Das, Sandeep Kumar Behera, Monali Sahoo, Lopamudra Subudhi, et al.
The disease tuberculosis, caused by, is one of the leading causes of global human mortality. The rise of multidrug and extensively drug-resistant strains of the pathogen and the limited efficacy of the BCG vaccine is one of the major concerns worldwide. Conventional chemotherapy …
Yuki Sakai, Miki Miyazawa, Akifumi Hisada, Yukari Tanabe, Satoshi Arakawa, et al.
…terium tilburgii is the causative agent of disseminated non-tuberculosis mycobacterial infections in individuals who are immunocompromised, including those with human immunodeficiency virus infection. Owing to its non-culturable nature, identification of M. tilburgii relies solel…
Elly van Riet, Björn Corleis, Birgitte K Giersing, Mark Hatherill, Erlina Burhan, et al.
In 2021, a global tuberculosis vaccine research and development roadmap proposed a series of actions to accelerate the development of new, effective, and affordable vaccines that are urgently needed to eliminate tuberculosis globally. Since then, the pipeline has diversified, sev…
Priya Yadav, Sheetal Gandotra
… requiring tight regulation during infection. Mycobacterium tuberculosis, the causative agent of tuberculosis and the leading cause of death from a single infectious agent, exemplifies an extreme adaptation to lipid-rich environments. Recent studies have uncovered coordinated hos…
Manjula Datta, M P Radhamani, Manjula Singh, Soumya Swaminathan, Rema Mathew, et al.
**BACKGROUND AND OBJECTIVES:** A study of tuberculosis in children was undertaken in the outpatient departments of four hospitals in Chennai city by the Tuberculosis Research Centre of the Indian Council for Medical Research. The objective of this partial analysis was to assess t…
Diah Handayani, Muhammad Faris Indratmo, Ardiana Kusumaningrum, Ahmad Fadhil Ilham, Febriana Catur Iswanti, et al.
Macrophages play a key role in controlling tuberculosis infection. This pilot study aimed to analyze the macrophage profile in drug-resistant tuberculosis patients compared to a group of close contacts diagnosed with latent infection and a group of healthy. The Interferon Gamma R…
Komal Saxena, S Shyni Carmel Mary, Prolay Ghosh, Chinnem Rama Mohan, Mohd Naved, et al.
**BACKGROUND:** Tuberculosis (TB) is still the largest cause of death in the world, especially in countries with low and medium incomes. Multi-Drug Resistant Tuberculosis (MDR-TB), which is resistant to isoniazid and rifampicin, is a new type of tuberculosis that makes treatment …
Gabriela Sadigurschi, Maria Cristina Caetano Kuschnir, Ewerton Alves Portela Dos Santos, Bruno Rangel Antunes da Silva, Celia Menezes Cruz Marques, et al.
Tuberculosis (TB) is a preventable and curable disease caused by the bacillus Mycobacterium tuberculosis. In 2022, according to the World Health Organisation (WHO), TB was the second leading cause of death worldwide caused by a single infectious agent, after coronavirus disease (…
José Cruz Mendoza-Torres, Nayar Durán-Hernández, José Alberto Choreño-Parra, Carlos Sánchez-Garibay, Citlaltepetl Salinas-Lara
**BACKGROUND:** Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a primary global health concern, with significant long-term sequelae. Central nervous system TB (CNS-TB) is a clinical spectrum with entities such as tuberculous meningitis and tuberculomas. Em…
Swati Jaiswal, Samreen Fatima, Erandi Velarde de la Cruz, Satyendra Kumar
…ite significant advances in research over the past century, Tuberculosis (TB) remains a formidable global health concern. TB granulomas are organized structures composed of immune cells, that serve as the body's primary defense against the spread of Mycobacterium tuberculosis (Mt…
Koushik Mukherjee, Pritam Saha, Kirat Kumar Ganguly, Somjyoti Chakraborty, Swarnali Ghosh, et al.
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a global health threat. Despite advances in diagnostics and treatment regimens, it infects millions annually. It remains a significant global health challenge, particularly due to the appearance of resistance towar…
Guiyi Ji, Yunxing Fu, Linlin Song, Rong Hu
Female genital tuberculosis (FGTB) is a major cause of infertility in regions where it is common, causing permanent damage to the reproductive tract. It mainly causes fibrosis and blockage of the fallopian tubes, directly hindering gamete movement. Meanwhile, FGTB leads to a decl…
Haorong Chen, Sijing Liang, Wenli Li, Ting Cao, Shujun Geng, et al.
…ines the potential of exosome analysis in diagnosing latent tuberculosis infection (LTBI). Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a significant public health challenge due to its high incidence worldwide. LTBI is a critical link in TB prevention and cont…
P Tejaswani, Debashis Das, Spandan Kumar, Amit Kundu, Kousar Jahan, et al.
Tuberculosis remains a deadly infectious disease with 1.09 million deaths and 10.8 million new cases reported in 2023. Escalating drug resistance and mortality rates worsen the situation. To address these issues, new TB agents with improved activity, better enzyme activation, low…
Mariana Araújo-Pereira, Bruno B Andrade
Tuberculosis infection (TBI) affects approximately one quarter of the global population and constitutes the principal reservoir sustaining future cases of tuberculosis disease (TBD). Interferon-gamma release assays (IGRAs) have become central tools for identifying TBI, particular…
James A Seddon, Jay Achar, Amyn A Malik, Jennifer Hughes, Joseph Burzynski, et al.
…ctious multidrug-resistant or rifampicin-resistant (MDR-RR) tuberculosis are at risk of developing tuberculosis disease. Historically, insufficient empirical evidence for preventive treatment in this group has permitted inadequate guidance for clinical decision making. However, s…
Ritu Raj Patel, Vidyasagar, Sudhir Kumar Singh, Meenakshi Singh
Despite being a preventable and treatable disease, tuberculosis (TB) remained the second leading infectious cause of death globally in 2022, surpassed only by COVID-19. The death rate from TB is influenced by numerous factors that include antibiotic drug resistance, noncompliance…
Zhengshu Ye, Zeliang Yang, Jiachang Zhang, Ying Wang, Xinting Yang, et al.
Mycobacterium tuberculosis (Mtb) is the primary pathogen that causes tuberculosis in humans. As the primary target cells, macrophages employ reactive oxygen species (ROS) as a crucial defense against Mtb. However, the dynamic and reciprocal interplay between Mtb, macrophages, and…
Mainak Ghosh, Monali Lahiri, Aman Dalal, Kishan Kumar Parida, Nitin Pal Kalia
Tuberculosis (TB) is one of the major life-threatening diseases caused by a single pathogen which has become a social menace owing to its high resistance. TB has even surpassed AIDS prior the COVID 19 pandemic. Every year the number of affected persons is increasing exponentially…
Parissa Farnia, Ali Akbar Velayati, Jalaledin Ghanavi, Poopak Farnia
…ion of functional proteins during dormancy in Mycobacterium tuberculosis (Mtb) through in vitro experiments provides crucial insights into the bacterium's survival mechanisms and pathogenicity. Dormancy constitutes a pivotal phase in the Mtb life cycle, enabling the pathogen to p…
Indu Singh, Juhi Sharma, Divakar Sharma, Arun Ratn, Deepa Bisht, et al.
… bedaquiline holds promise for treating multidrug-resistant tuberculosis (MDR-TB). Still, the inflation in bedaquiline resistance has alarmed the global public health crisis, indicating the need for a new treatment strategy. Several scientific studies have reported a high inciden…