Showing 101–125 of 200 documents
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Joséphine Khady Badiane, Zelika Harouna Hamidou, Abdou Padane, Rita Zgheib, Hamadou Oumarou Hama, et al.
… 49 sub-Saharan African countries, which account for 85% of tuberculosis cases in Africa (WHO, 2025), to monitor the genomic dynamics of Mycobacterium tuberculosis complex strains responsible for the disease was examined for the period 2000-2025. A total of 8141 GenBank entries, …
Anna Starshinova, Igor Kudryavtsev, Artem Rubinstein, Irina Dovgalyuk, Anastasia Kulpina, et al.
Tuberculosis (TB) remains a fatal disease primarily transmitted through airborne droplets, with children who are the most susceptible, particularly in the areas with poor tuberculosis control. The BCG vaccine, developed by Albert Calmette and Camille Guérin, has a history sp…
Margarida Saraiva, William J Branchett, Jyothi Rengarajan, Anne O'Garra
Tuberculosis (TB) remains a global health issue and leading cause of death. Understanding the immune response to Mycobacterium tuberculosis infection is critical to advance TB control. Although immune factors involved in protection against TB have long been identified, these cann…
Mohini Agrawal, K Shyamsundar, Keerthana Raghu, Rajiv Raman, L Dhanurekha, et al.
**BACKGROUND:** Intraocular tuberculosis (OTb) is a sight-threatening manifestation of Mycobaterium tuberculosis infection. It is characterized by a wide spectrum of clinical phenotypes, including anterior uveitis, posterior uveitis, retinal vasculitis, and choroiditis. Diagnosis…
Maria-Cristina I Loader, Deborah L W Chong, Keira H Skolimowska, Jon S Friedland
…the interface of inflammation, tissue injury, and repair in tuberculosis. In pulmonary tuberculosis, dysregulated MMP activity drives extracellular matrix degradation, cavitation, and remodelling that contribute to post-tuberculosis lung disease. In tuberculous meningitis, MMPs h…
Rodolfo L Chávez-Domínguez, Martha Torres, Atziri A Acevedo-Domínguez, Jesús A Ibarra-Inocente, Claudia Carranza
Pulmonary tuberculosis, caused by(Mtb), remains one of the leading causes of infectious disease-related mortality worldwide. In parallel, lung cancer represents the most lethal neoplasm, with high mortality rates globally. Emerging studies suggest that chronic Mtb infection may c…
Roopendra Kumar, Jagdeep Singh Sohal, Ajay Vir Singh, Devendra Singh Chauhan
… nonresponsive multidrug-resistant (MDR) cases of pulmonary tuberculosis (TB). It offers new hope in the global fight against drug-resistant TB, which remains a major health challenge. However, the pursuit of better treatment outcomes has been confronted by the rapid emergence of…
Rosella Centis, Lia D'Ambrosio, Giovanni Battista Migliori
Tuberculosis is an airborne infectious disease treated with combination therapeutic regimens. Adherence to long-term antituberculosis therapy is crucial to maintain adequate blood drug level. The emergence and spread of drug-resistantstrains is mainly favored by the inadequate me…
Abhijit Mukherjee, Pallabi Dasgupta, Alapan Bandyopadhyay, Sharmistha Bhattacherjee
**BACKGROUND:** Paediatric tuberculosis is a surrogate indicator of ongoing TB transmission. The present study explores the relationship between the burden of paediatric TB cases and their ecological determinants in different states of India. **METHODS:** Based on a conceptual m…
Shixiong He, Changjiao Luan, Jiaqi Gao, Feng Lu, Fang Tian, et al.
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis, which is widespread and harmful worldwide. It can attack multiple organs throughout the body, with pulmonary tuberculosis being the most common. The Global Tuberculosis Report 2024 shows an increase …
Digby F Warner, Amy K Barczak, Maximiliano G Gutierrez, Valerie Mizrahi
Since the release of the first Mycobacterium tuberculosis genome in 1998, major advances have been made in understanding the biology of this pathogen, the leading infectious cause of death in modern human history. In this Review, we outline the physiological and metabolic feature…
Emily A Kendall, Claudia M Denkinger, Adithya Cattamanchi, David W Dowdy, Jason R Andrews
Tuberculosis encompasses a spectrum of characteristics-including bacillary burden, clinical severity, and access to care-that are relevant to clinical and epidemiological outcomes and the performance of diagnostic assays. The value of diagnostic assays depends not only on their n…
Karthikeyan Sundaram, Sridhar Rathinam, Venkataraman Prabhu
Tuberculosis and systemic fungal diseases are opportunistic and challenging to diagnose. However, in immunocompromised people, especially people living with human immunodeficiency virus (PLHIV), the signs and symptoms of both diseases highly imitate each other. Primarily, chronic…
Inayat Singal, Anam Anil Alwani, Rakesh Kumar
…ort, like mobile applications, improve treatment results in tuberculosis. However, the dearth of knowledge on these applications have led to their limited use in India. Our study aims to fill this lacuna by assessing the functionality and intended use of mobile applications relat…
Parul Verma, Geeti Khullar, Satyaki Ganguly, P Narsimha Rao, Pragya Nair, et al.
Cutaneous tuberculosis (CTB) is an important type of extrapulmonary tuberculosis (EPTB), especially in countries where the tuberculosis (TB) load is high. It is reported from all over the globe with varying incidence, affecting all age groups, and it presents with different clini…
Vaishali Sandeep Baste, Padmavati Shrivastava, Rahul Patil, Neha Rana, Preeti Pandurang Kale, et al.
…tings, such as central Africa or India, where the burden of tuberculosis remains great [23,39], there are very few datasets that have such annotations. Objective This study aims to address the challenge associated with data scarcity and class imbalance in analyzing tuberculosis C…
Ming-Rui Sun, Jia-Yin Xing, Xiao-Tian Li, Ren Fang, Yang Zhang, et al.
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB) in humans and animals. Mtb invades the host's lungs via airborne transmission, infecting macrophages and causing TB. In some cases, the infection can spread to other tissues and organs. Despite the avail…
Yifei Cai, Leiliang Zhang
Mycobacterium tuberculosis (Mtb) protein tyrosine phosphatase A (PtpA) is a crucial tyrosine phosphatase involved in the pathogenesis of tuberculosis. Structural analyses reveal that the W-loop and conserved cysteine residues are essential for the catalytic activity of PtpA, with…
Mohd Shariq, Javaid Ahmad Sheikh, Anwar Alam, Nasreen Z Ehtesham, Seyed E Hasnain
Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a major global health challenge, exacerbated by prolonged treatment regimens, variable vaccine efficacy, and the emergence of drug-resistant strains. Beyond conventional pathogen-targeted antibiotics, increasing att…
Shad Ahmad, Adil Husain, Parul Jain, Firoz Ahmad
**BACKGROUND:** Central nervous system tuberculosis (CNS-TB), most frequently manifesting as tuberculous meningitis, is associated with high mortality and significant long-term neurological morbidity. Increasing evidence suggests that disease severity and neurological damage are …
Rajwinder Kaur, Varsha Sharma, Anju Kumari
Female genital tuberculosis (FGTB), a form of extrapulmonary tuberculosis caused by Mycobacterium tuberculosis (MTB), is an under-recognized but significant cause of female infertility, particularly in developing countries. It primarily spreads through the hematogenous route and …
Pamela Pei, Livia Qoshe, Grady Florance, Ankur Pandya, Milton C Weinstein, et al.
…hetical trial comparing mortality associated with different tuberculosis screening strategies among hospitalized patients with human immunodeficiency virus (HIV) in South Africa. Apart from expressing VOI as conventional, "aggregated" net monetary benefit (NMB), we assessed "disa…
Itai M Magodoro, Leigh A Kotze, Cari J Stek, Alexander West, Andrea Le Roux, et al.
**INTRODUCTION:** Tuberculosis (TB) remains a major infectious threat to global health, while type 2 diabetes mellitus (diabetes) has reached epidemic proportions in many regions of the world. In low- and middle-income countries (LMIC) and among indigenous and minority communitie…
Laura Olbrich, Nathan J L Mudrak, Ceri Evans, Padmini Salgame, Jerrold Ellner, et al.
…arly from infectious diseases. Given the high prevalence of tuberculosis in populations with high HIV prevalence, the effect of HIV exposure on tuberculosis is therefore of particular interest. In this Review, we contextualise and reflect on the existing literature for CHEU with …
Qiang Ji
**BACKGROUND:** Abdominal tuberculosis is a rare and diagnostically challenging form of extrapulmonary tuberculosis that can closely mimic advanced ovarian cancer both clinically and radiologically. This case is reported to highlight this diagnostic dilemma and the serious postop…