Showing 76–100 of 200 documents
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Karthikeyan Sundaram, Venkataraman Prabhu
Tuberculosis is an infectious disease spread through airborne droplet nuclei.is the etiological agent of this infection. Mycobacteria can cause active tuberculosis or asymptomatic latent infection due to its complex biology and host immunological responses. The genes of mycobacte…
Haiyang Fu, Wenqiang Sun, Ye Xu, Haiyun Zhang
Tuberculosis (TB), especially pulmonary tuberculosis (PTB), is a prevalent infectious disease affecting the respiratory system and is characterized by high morbidity, disability, and mortality rates that significantly impact the quality of life of patients and their families. Hos…
Xiaoying Jin, Jiajun Wang, Yongdui Ruan, Jiaxiang Li, Xinen Kong, et al.
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is one of the most prevalent infectious diseases worldwide. Nitric oxide (NO) is produced by the reaction of arginine and oxygen catalyzed by nitric oxide synthase (NOS) in mammals. Several studies have highlighted the …
Anjali K Mahato, Rupal Rai, Rashmi Chourasia, Anirudh K Singh, Shivendra K Chaurasiya
Mycobacterium tuberculosis (M. tuberculosis), the causative agent of tuberculosis (TB), remains a leading global health threat, exacerbated by rising drug resistance and the ability of this pathogen to persist within host macrophages. Central to the intracellular survival of M. t…
Parul Gupta, Ravindra Kumar, Rituraj Niranjan
…lular processes related to the immune system. miRNAs during tuberculosis (TB) infection are considered regulatory factors for the host immune system.has a great ability to survive and multiply in phagocytic cells, which makes it difficult to treat. It can replicate through variou…
Shreya Chakraborty, Devi Rajeswari V
Tuberculosis (TB) has become the most common reason for contagious disease-related fatalities globally. Due to the estimated 8.6 million fresh tuberculosis infections and 1.6 million fatalities, this disease is a leading contributor to mortality globally. Tuberculosis refers to a…
P Ponmani, Ratnesh Sinha, Sayan Kumar Das
Tuberculosis (TB) is one of the major public health problems which has cursed humanity for centuries. 45 % of the global incidence of TB and 50% of global mortality due to TB is contributed by the World Health Organisation (WHO) South-East Asia (SEA) Region. India is the top cont…
Jianfei Zhang, Du Zhang, Kaixi Tan, Bin Jiang
…tra-gene sequencing confirmed the presence of Mycobacterium tuberculosis, leading to a definitive diagnosis of mycobacterial infection. **INTERVENTIONS:** The patient received a 2-month intensive anti-tuberculosis regimen consisting of rifampicin, isoniazid, ethambutol, and pyra…
Qun Zhang, Yi-Qian Han, Wei-Feng Xu, Mei-Yan Wei, Yu-Cheng Gu, et al.
Tuberculosis (TB) is one of the most significant health perils that has claimed more lives than any other contagious disease over the past 2000 years. The treatment of tuberculosis has been severely compromised due to drug-resistant strains. In this review, we cover the field of …
Thi Mai Nguyen, Emily Lai-Ho MacLean, Xiaomei Zhang, Sophia B Georghiou, Hui Xia, et al.
The paucity of diagnostic tests for isoniazid-resistant tuberculosis is concerning, given its status as the most common form of drug-resistant tuberculosis and a gateway to multidrug-resistant diseases. Molecular drug-susceptibility testing has improved access to timely diagnosis…
Parissa Farnia, Ali Akbar Velayati, Jalaledin Ghanavi, Poopak Farnia
The pathogenic potential of Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis, is attributable primarily to its complex and highly specialized repertoire of molecular determinants, comprising both proteins and lipids. These virulence factors operate synergis…
Emily A Kendall, David W Dowdy
Screening populations at high risk for tuberculosis might improve clinical outcomes and reduce transmission, but the value and cost-effectiveness of population-based screening depend on the uncertain health impact of early tuberculosis detection. In this Personal View, we propose…
Nitinkumar Marotrao Waghmare, Bharti Jagdale, Rahul Bhagwat Mapari, Harshada Bhushan Magar, Rohini Pochii, et al.
Having both diabetes and tuberculosis (TB) at the same time is a big public health problem because they affect each other in two ways: they make people more likely to get the diseases and they make the diseases worse. Active tuberculosis is more likely to happen if you have diabe…
Pushpa Choudhary, Uma Phalswal, Mamta
Many people identify tuberculosis as a complex disease that requires a wide range of restrictions, lifestyle changes, and behavioral changes. Well-managed tuberculosis necessitates specific self-care management behaviors to not only control the disease but also prevent drug resis…
Huilin Fang, Yan Xiong, Beibei Fu, Haibo Wu
Tuberculosis (TB) is an airborne infectious disease caused by the Mycobacterium tuberculosis (Mtb) complex organism. Alveolar macrophages (AMs) play key roles in immune defense, antigen presentation, immune regulation, and immune secretion during Mtb infection. Notably, AMs exhib…
Karthikeyan Sundaram, Sridhar Rathinam
Tuberculosis is a fatal infection transmitted through airborne droplet nuclei. The etiological agent is Mycobacterium tuberculosis, an acid-fast bacillus. Drug-resistant tuberculosis poses a global challenge, with specific mycobacterial genes intricately associated with drug resi…
David G Russell, Nelson V Simwela, Joshua T Mattila, JoAnne Flynn, Henry C Mwandumba, et al.
…e the primary host cell type for infection by Mycobacterium tuberculosis in vivo. Macrophages are also key immune effector cells that mediate the control of bacterial growth. However, the specific macrophage phenotypes that are required for optimal immune control of M. tuber…
Zhicong Xiang, Liuyu, Hequn Zou
…biological agents, potentially elevating the risk of latent tuberculosis infection (LTBI) reactivation and Mycobacterium Tuberculosis (MTB) dissemination. Tumor necrosis factor-α(TNF-α)is crucial in immune responses, and TNF-targeted therapies could raise the risk of …
Anjali Saxena, Summer Bhagra, Shuvayoo Das, Naveen Kaushik, Biswajit Saha
…drug-resistant and extensively drug-resistant strains of M. tuberculosis. The escalating prevalence of multidrug-resistant and extensively drug-resistant strains, compounded by the pathogen's extraordinary capacity to survive within host macrophages and pharmacologically impenetr…
Rūta Mereškevičienė, Edvardas Danila
Tuberculosis remains a significant public health challenge globally. The emergence of multidrug-resistant Mycobacterium tuberculosis strains presents one of the biggest hurdles in tuberculosis management. Both first- and second-line tuberculosis drugs are associated with common a…
F L Adão-Araújo, B G Ferreira, R Pontarolo, F S Tonin, S M Raboni
…ed as promising alternatives for the diagnosis of pulmonary tuberculosis, especially in settings where sputum collection is challenging and laboratory infrastructure is limited. We aimed to map the evidence on advanced technologies available for detecting pulmonary tuberculosis u…
Junhui Liu, Qiusheng Jing, Zhan Lian, Chunxiang Song, Qi Zhu
…of intrabronchial lipoma in a patient with active pulmonary tuberculosis. A tumor located in the right lower bronchus was unexpectedly discovered during a bronchoscopy. Following a biopsy, the histopathological analysis confirmed it to be a lipoma. After six months of regular ant…
Weibiao Han, Xuepeng Bai, Yongxiang Cheng, Chenglong Xin, Ruifeng Fan, et al.
**BACKGROUND:** Surgical treatment of thoracic spine tuberculosis using traditional procedures is often challenged by high trauma and slow recovery. This study aimed to investigate the short- and medium-term efficacy and safety of Uniportal Video-Assisted Thoracoscopic Surgery, a…
Karthikeyan Sundaram, Leela Kagithakara Vajravelu
The association between tuberculosis and gut microbiota is notable clinical synergistic action. Tuberculosis is a highly contagious illness that poses a huge global risk., an acid-fast bacillus, is responsible for one of the top ten death associated lethal infection. The study of…
Huicong Liu, Haoran Li, Shanshan Li, Yuanyuan Shang, Shenjie Tang, et al.
Tuberculosis (TB) is a chronic infectious disease caused by(). Despite significant advancements in anti-tuberculosis treatment strategies in recent years, TB remains a major infectious disease threat worldwide. Chronicinfection drives T cell exhaustion-characterized by upregulate…