Showing 51–75 of 200 documents
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Jinsoo Min, Bruno B Andrade, Ju Sang Kim, Yoolwon Jeong
Recent advancements in tuberculosis treatment research emphasize innovative strategies that enhance treatment efficacy, reduce adverse effects, and adhere to patient-centered care principles. As tuberculosis remains a significant global health challenge, integrating new and repur…
Xingyu Lu, Yiyi Hu, Yue Hu, Fei Zhao, Peiyang Fan, et al.
Tuberculosis (TB) is a serious disease that poses a significant threat to the health of children and adolescents, with(PTB) being the most common type. Due to the lack of specificity in clinical manifestations and symptoms, early screening and diagnosis of pediatric pulmonary tub…
Pauline Howell, Jonathan Stillo, Anja Reuter, Tendai Nkomo, Carole D Mitnick, et al.
Drug-resistant tuberculosis is entering a new and dangerous phase. Bedaquiline and other newer drugs have transformed drug-resistant tuberculosis treatment, yet resistance to these agents is now being reported across high-burden settings. In some regions, baseline bedaquiline res…
Onesime Mbulayi, Saint-Jean Djungu, Loukia Aketi, Mohammed Amine Koulali, Hanae Azzaoui, et al.
Tuberculosis, an infectious disease caused by, poses a major global health challenge. Despite being largely controlled for several decades, tuberculosis has experienced a resurgence in recent years. China has the second highest incidence of tuberculosis globally, with a prevalenc…
Supriya Mallick, Manish Shankar, Satyadeo Choubey, Arshad Ejazi, Rakesh Kumar, et al.
**BACKGROUND:** Multidrug-resistant tuberculosis continues to be a major threat to mankind and is a major social and economic burden to society. Line probe assay (LPA) is a method for detecting Mycobacterium tuberculosis (MTb) in combination with resistance to rifampicin and ison…
Cara Adolph, Simon C Mendelsohn, Laura E Via, Leonardo Martinez, Cecilia S Lindestam Arlehamn, et al.
Progress in tuberculosis vaccine development is hindered by the incomplete understanding of protective immunity and other disease mechanisms. An interconnected network of sample biorepositories from tuberculosis studies could help to address these gaps. To assess the feasibility …
Jason R Andrews, Salome Charalambous, Gavin Churchyard, Frank Cobelens, Carlos Fernández-Escobar, et al.
…are among the populations experiencing the highest rates of tuberculosis. Prisons typically create ideal conditions for Mycobacterium tuberculosis transmission, including overcrowding and prolonged exposure in poorly ventilated environments, and often have populations at high ris…
Cara Adolph, Simon C Mendelsohn, Laura E Via, Leonardo Martinez, Cecilia S Lindestam Arlehamn, et al.
Tuberculosis remains a leading cause of death, underscoring the urgent need for a new vaccine. Progress in vaccine development is hampered by incomplete understanding of how Mycobacterium tuberculosis causes infection and disease, and of protective immunity following natural infe…
Roshna Lytton, Nanda Kumar Paniyadi, Prasanta Raghab Mohapatra, Priyanka Singh, Anuradha Kumari, et al.
**INTRODUCTION:** Individuals diagnosed with tuberculosis often experience concerns regarding potential social isolation affecting their family life, education, marriage, occupation, treatment, and social life. The goal of the present study was to determine the prevalence of stig…
Dinesh Kumar Sharma
Since the early centuries until the present, tuberculosis has been a global illness with no cure. However, the sickness remains dormant in the afflicted individuals in certain circumstances. Due to the thick lipid mycobacterial wall and the challenging medication delivery into th…
Alicia M Gutiérrez-Mauricio, Juan Valentín Trujillo-Paez, Luis Alberto Trejo-Martinez, Bruno Rivas-Santiago, Paola Pérez-García, et al.
Tuberculosis (TB) is a contagious infectious disease caused by the bacillus Mycobacterium tuberculosis (Mtb). It is transmitted through small particles in the air (<5 µm) expelled by active tuberculosis patients; when inhaled by a new host, they can potentially cause …
Akshay Girish Manikoth, Manoj Kumar Bisht, Sudip Ghosh, Sangita Mukhopadhyay
Tuberculosis is an infectious disease primarily caused by the bacterium Mycobacterium tuberculosis. This bacterium infects about 10 million and kills about 1.6 million people annually. M. tuberculosis infects macrophages and manipulates its defense functions …
Anca Ionela Fâcă, Denisa Ioana Udeanu, Andreea Letiția Arsene, Beatrice Mahler, Doina Drăgănescu, et al.
Tuberculosis is an infectious condition caused by, primarily targeting the pulmonary system, with the potential to disseminate to various other organs via the haematogenous pathway, ranking among the top ten causes of global mortality. Tuberculosis remains a serious public health…
Meiru Chen, Yating Wang, Dongqiang Zhao
**BACKGROUND:** Hepatic hilar tuberculosis lymphadenitis is a rare condition that often mimics other diseases, leading to diagnostic challenges due to its nonspecific clinical presentation. It can be easily mistaken for a malignant tumor, complicating the diagnostic process. **C…
Mingyang Hong, Xu Huang, Huiming Zhu, Jiahui Ma, Feng Li
…gained significant attention in recent years, especially in tuberculosis research. Tuberculosis poses a major global public health threat. Its complex pathological mechanisms and worsening drug resistance urgently necessitate new research breakthroughs. The role of circRNA in myc…
Jamilah Meghji, Sara C Auld, Gregory P Bisson, Celso Khosa, Refiloe Masekela, et al.
…scribing the high burden of respiratory sequelae seen among tuberculosis survivors, including children, adolescents, and adults. This group of sequelae are known as post-tuberculosis lung disease and include parenchymal damage, airway disease, and pulmonary vascular disease. It i…
Ravindra Kumar Garg
…SE OF REVIEW:** The outcome of central nervous system (CNS) tuberculosis has shown little improvement over several decades, with diagnosis remaining unconfirmed in nearly half of the cases. This review highlights current insights and advancements in the diagnosis and treatment of…
Francisco de Assis Moura Batista, Juliana Iscarlaty Freire de Araújo, Fernanda Cunha Soares, Thalyta Cristina Mansano Schlosser, Clarissa Terenzi Seixas, et al.
Tuberculosis is an infectious disease with a substantial impact on public health, with the pulmonary form representing the most significant concern. The disease poses considerable risks to the elderly population, as it frequently manifests in conjunction with other age-related co…
Steven Howard Yale, Halil Tekiner, Eileen Scott Yale
…lopment and significance of medical eponyms associated with tuberculosis between 1909 and 1942, highlighting their contribution to the diagnosis of the disease. During this period, 16 eponymous signs were described, including the well-known Brudzinski sign for tuberculous meningi…
Mackenzie DuPont, Robert Castro, Sandra V Kik, Megan Palmer, James A Seddon, et al.
…of chest x-rays (CXRs) have been developed and approved for tuberculosis triage in adults but not in children. However, CXR is frequently the only adjunctive tool for clinical assessment in the evaluation of paediatric tuberculosis in primary care settings, and children would ben…
Karin Dijkman, Simone A Joosten, Leendert A Trouw
Tuberculosis continues to kill over a million people every year, with an additional 10 million people falling ill. The ongoing efforts to eradicate the disease are hampered by an incomplete understanding of the mechanisms involved in the defense against tuberculosis. It has becom…
Yang Zhang, Ruiying Wu, Mingrui Sun, Xiaotian Li, Ren Fang, et al.
Tuberculosis, a chronic infectious disease caused bycomplex, has re-emerged as the leading cause of death worldwide as a single infectious agent. The increasing prevalence of multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis poses a severe and growing t…
Angela Hidalgo-Gajardo, Bryan Mangui, Carla Villavicencio, Jorge R Toledo, Frank Camacho
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (MTB), Bacille Calmette-Guérin (BCG) is the only licensed vaccine for tuberculosis, but it provides limited and inconsistent protection against pulmonary TB in adults. Furthermore, current diagno…
Ying Wang, Daxing Cao, Guihua Liu
Treatment regimens for Tuberculosis (TB) primarily rely on first-line drugs such as isoniazid, rifampicin, ethambutol, and pyrazinamide. Although these drugs have been pivotal in the treatment of drug-resistant tuberculosis, their high costs limit widespread use in low- and middl…
Amitesh Gupta, Eshutosh Chandra, Parul Mrigpuri
The intersection of diabetes mellitus (DM) and tuberculosis (TB) constitutes a significant global health challenge, marked by complex disease interactions with profound clinical and public health consequences. TB, a historically prevalent infectious disease, and DM, a rising non-…