Showing 26–50 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Jingxian Ning, Rong Wang, Yuchen Pan, Xinru Fei, Wenxin Jiang, et al.
**OBJECTIVE:** Tuberculosis significantly affects human health and longevity. We aimed to systematically synthesize studies to summarize the median survival time range and years of potential life lost (YPLL) among tuberculosis patients. **METHODS:** We searched Web of Science, P…
Xinxin Fan, Muxing Chen, Di Wu, Youfei Lin, Xiaohong Chen
According to the 2024 World Health Organization (WHO)Global Tuberculosis (TB)Report, tuberculosis remains the leading cause of death from a single infectious agent, with 10.8 million new cases and 1.25 million deaths in 2023. Early and standardized treatment upon definitive diagn…
Vidya Mave, Mandar Paradkar, Francesca Conradie, Amita Gupta, Anchalee Avihingsanon, et al.
Over the past 80 years, tuberculosis treatment has evolved with the development of all-oral treatments, which are now given for 4-6 months for drug-sensitive tuberculosis and 6-9 months for drug-resistant tuberculosis. Treatment success is often reduced among people with HIV due …
Md Abdur Rahim, Hoonhee Seo, Indrajeet Barman, Mohammed Solayman Hossain, Md Sarower Hossen Shuvo, et al.
Tuberculosis, primarily caused by, is an airborne lung disease and continues to pose a significant global health threat, resulting in millions of deaths annually. The current treatment for tuberculosis involves a prolonged regimen of antibiotics, which leads to complications such…
Yu Lan, Isabel Rancu, Melanie H Chitwood, Benjamin Sobkowiak, Kate Nyhan, et al.
Tuberculosis remains a leading cause of infection-related mortality, and efforts to reduce its incidence have been hindered by an incomplete understanding of local Mycobacterium tuberculosis transmission dynamics. Advances in pathogen sequencing and spatial analysis have created …
Gregory P Bisson, Brian Allwood, Anthony Byrne, Gunar Günther, Celso Khosa, et al.
… substantial burden of long-term pulmonary impairment among tuberculosis survivors, marked variability in how post-tuberculosis lung disease is defined across research studies limits the comparison of findings and synthesis of evidence. To facilitate greater harmonisation within …
Rajeev Ranjan, Venkata Siva Reddy Devireddy
Drug resistant tuberculosis is a major public health concern, since the causative agent Mycobacterium tuberculosis is resistant to the most effective drugs against tuberculosis treatment ie., rifampicin and isoniazid. Globally, it accounts 4.6 percent of the patients with tubercu…
Timothy M Walker, James A Watson, David A J Moore, Mike Frick, Euzebiusz Jamrozik
Preventive therapy remains key to the elimination of tuberculosis and is typically offered to people with presumptive Mycobacterium tuberculosis infection to prevent active disease. Although the duration of tuberculosis preventive therapy has been reduced substantially over time,…
Nuttapon Jirakittiwut, Panan Ratthawongjirakul
**BACKGROUND:** Detecting tuberculosis (TB) remains challenging in low-resource settings due to limited access to advanced diagnostic tools. The emergence of isothermal amplification techniques, such as loop-mediated isothermal amplification (LAMP), presents a promising solution …
Dan Ye, Ning Gan, Yang Yang, Zhentao Fei, Huarui Liu, et al.
**BACKGROUND:** To examine the clinical features of adrenal tuberculosis to improve clinicians' diagnostic accuracy and treatment strategies. **METHODS:** We report on nine patients diagnosed with adrenal tuberculosis at the Shanghai Public Health Clinical Center between January…
Matthew J Saunders, Delia Boccia, Palwasha Y Khan, Lara Goscé, Antonio Gasparrini, et al.
… is likely to exacerbate a range of determinants that drive tuberculosis, the world's leading cause of death from a single infectious agent. However, tuberculosis is often neglected in wider climate health discussions. Commissioned by WHO, we developed an analytical framework out…
Stacie Burke
…ammation is the immune system's natural response to initial tuberculosis infection. Tuberculosis bacteria have gained adaptations to manipulate the inflammatory process, sometimes settling into latency and containment in granulomas, ensuring their survival. Grounded in an evoluti…
Qiuyue Song, Junlin Liu, Chunhua Wang
Tuberculosis is a severe infectious disease caused by(MTB) infection and poses a serious public health challenge globally. The prevalence of multidrug-resistant MTB in countries with a high burden of tuberculosis has further increased the challenges of tuberculosis prevention and…
Tyler S Brown, Kristin Nelson, Stephen Kissler, Leo Martinez, C Robert Horsburgh, et al.
Tuberculosis remains a persistent threat to global public health. Ultimately, future progress towards tuberculosis elimination is contingent on our ability to interrupt Mycobacterium tuberculosis transmission between individuals who are infectious and their susceptible contacts. …
Amira Mahmood, Mohammad Bilal Ashfaq, Catherine Drain, Eoin Melby, Michael Hunter, et al.
Tuberculosis remains the biggest global killer from infectious causes, with an estimated 1.25 million deaths per year. The quadruple drug regimen of rifampicin, isoniazid, pyrazinamide, and ethambutol has been standard therapy for 40 years, with good outcomes in patients with dru…
Karthikeyan Sundaram, Sathyapriya Subramani, Venkataraman Prabhu
Mycobacterium tuberculosis (MTB) causes Tuberculosis (TB), which is a fatal infectious disease. Timely diagnosis of tuberculosis is crucial, and the conventional culture method is time-consuming and smear microscopic staining is less sensitive. Significantly, rapid molecular diag…
Yinfeng Su, Xingxing Kong, Zhanpeng Chen, Xiaomin Wang, Shuihua Lu
Tuberculosis in pregnancy is a series of diseases caused by(). Exact global incidence rates are difficult to obtain and are expected to be similar to those in the general population, with potentially higher rates in developing countries. Tuberculosis in pregnancy is associated wi…
Jalaledin Ghanavi, Poopak Farnia
Tuberculosis and its pathogen, Mycobacterium tuberculosis complex, are a major health challenge. The causative agent of tuberculosis is M. tuberculosis complex and is transmitted through airborne droplets. Tumor necrosis factor-alpha (TNF-α) is one of the cytokines that med…
André Avarese Figueiredo, Humberto Elias Lopes, Augusto de Azevedo Barreto, Victor Silvestre Soares Fanni, Filipi Silva Kefler, et al.
**INTRODUCTION:** Urogenital tuberculosis (UGT) is a common manifestation of extrapulmonary tuberculosis and can affect all organs of the urinary tract and male genital tract. The actual main problem of UGT is late diagnosis and a high prevalence of urogenital organ destruction. …
Emmanuel M Sindato
Tuberculosis and diabetes are major global health concerns, with their prevalences projected to increase disproportionately in the low- and middle-income countries (LMICs). The convergence of tuberculosis and diabetes impact is also expected to rise, posing a negative synergism t…
Moorine P Sekadde, Silvia S Chiang, Annemieke Brands, Martina Casenghi, Chishala Chabala, et al.
…(aged 0-9 years) and adolescents (aged 10-19 years) develop tuberculosis disease. Tuberculosis ranks among the top ten causes of death in children younger than 5 years. The primary driver of tuberculosis-related mortality in children and young adolescents is the failure to detect…
Chetan Seshadri, JoAnne L Flynn, Pauline Maiello, Dirk Schnappinger, Robert J Wilkinson, et al.
… vaccine development for infectious diseases. Mycobacterium tuberculosis is a human-adapted pathogen that is the leading infectious cause of death worldwide. M tuberculosis infection results in a spectrum of clinical outcomes that are incompletely modelled in animals. To date, th…
Spasoje Popevic, Nikola Maric, Slobodan Belic, Marija Karapandzic, Sanja Dimic Janjic, et al.
Endobronchial tuberculosis is a rare form of tuberculosis that is characterized by the presence of tuberculous granuloma within the respiratory tract, usually in the trachea or main bronchi. Multiple key notes regarding this form make it difficult to detect and treat, which can l…
Siqi Lin, Qianqian Zhang, Juan Liu, Bojie Lin, Daina Zhao, et al.
The emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb), coupled with lengthy treatment cycles and adverse side effects of traditional therapies, poses a significant global challenge in the form of tuberculosis (TB). Photodynamic therapy (PDT) generates reacti…
Chenxi Li, Xiangyuan Chen, Ping Zeng
Latent tuberculosis infection (LTBI) is a state of sustained immune response to Mycobacterium tuberculosis (MTB) antigens, without clinical evidence of active tuberculosis. Rheumatic diseases, a common type of autoimmune disease, are often treated with glucocorticoids, immunosupp…