Showing 1–25 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Ayushi Sharma, Gyanendra Singh, Rahul Shrivastava
Tuberculosis is a global emergency. Despite two decades of intense research to understand and cure the disease, biological uncertainties prevail and hamper the therapeutic progress. Increasing incidences of multidrug-resistant (MDR) and extensively drug resistant (XDR) Mycobacter…
Steven G Smith, Ruth Bowness, Jacqueline M Cliff
Host-directed therapy could potentially revolutionize tuberculosis control as an adjunct to traditional antibiotics for the treatment of tuberculosis disease and as a strategy to prevent disease progression following Mycobacterium tuberculosis infection. The growing type 2 diabet…
Richard G White, Gavin J Churchyard, Katherine C Horton, Andrew Fiore-Gartland, Marcel A Behr, et al.
Current licensure trials of new vaccines to prevent tuberculosis disease use bacteriologically confirmed symptomatic tuberculosis disease as the primary endpoint. Globally, the incidence of symptomatic tuberculosis disease is low, making licensure trials large, long, and expensiv…
Vaishnavi Vivekanandan, Arun K, Sindhu Hasini Doredla, Harini Ramanujam, Ranjani Singaraj, et al.
Tuberculosis (TB), caused by members of the Mycobacterium tuberculosis complex (MTBC), remains a significant global health concern. While zoonotic transmission of M. bovis from cattle to humans is well documented, reverse zoonotic transmission of M. tuberculosis from humans to ca…
Florence Mutua, Ruey-Chyi Su, Terry Blake Ball, Sandra Kiazyk
…ype I interferon-induced transcriptomic signature in active tuberculosis suggests a potential role for these interferons in the pathogenesis of tuberculosis. Comorbidities such as human immunodeficiency virus, diabetes, systemic lupus erythematosus, end-stage renal disease, and c…
Barbara E de Bary, Marlies Heudobler, Alois Fürst, Kirsten Utpatel, Elisabeth Schuierer, et al.
**INTRODUCTION:** Tuberculosis (TB) remains a significant global health issue, with extrapulmonary manifestations accounting for a notable proportion of cases. Perianal tuberculosis, however, is a rare presentation of TB, often leading to delayed diagnosis due to its nonspecific …
Kashish Choudhary, Sana Tanweer, Mohd Zaid Choudhary, Sonam Grover
Tuberculosis (TB) is a health concern resulting in 10.8 million cases every year. In 2024, TB had the highest fatalities second only to COVID-19. Global TB management has become difficult due to rise of multi-drug resistant (MDR) and extensively drug-resistant (XDR) TB. Therefore…
Rajita Bhavaraju, Bruno Andrade, Suzanne Siminski, Soyeon Kim, Mark Hatherill, et al.
**BACKGROUND:** Clinical tuberculosis (TB) research has been hampered by a lack of reliable predictors of Mycobacterium tuberculosis infection progression and active TB treatment's cure, relapse, and failure. Given host and bacterial variability, large sample sizes from harmonize…
Pooja Khandelwal, Neelam Yadav, Arzoo Saini, Neelam Singh Sangwan
Tuberculosis (TB) remains one of the most serious and deadly infectious diseases worldwide. Despite being preventable and curable, it is responsible for increasing the annual fatality by millions. The situation is even more alarming in the developing nations, where TB ranked in t…
Carlos Martín, Jesús Gonzalo-Asensio, Nacho Aguiló, Ainhoa Arbués
Despite major advances in diagnosis and treatment, tuberculosis (TB) control - and ultimately elimination - will remain unachieved without a vaccine capable of preventing pulmonary disease and transmission. Bacille Calmette-Guérin (BCG), a live attenuated vaccine derived fro…
Tonino Alonzi, Elisa Petruccioli, Alessandra Aiello, Federica Repele, Delia Goletti
Tuberculosis (TB) remains the leading cause of death worldwide from a single infectious disease. An estimated quarter of the world's population, about 2 billion people, has an immune response to Mycobacterium tuberculosis (Mtb) without clinical, microbiological, or radiological s…
Venus Marie R Rojas, Michaela Zwyer, Selim Bouaouina, Daniela Brites, Sonia Borrell, et al.
The Mycobacterium tuberculosis complex (MTBC) phylogenetic lineages 1-4 (L1-L4) are the main causes of human tuberculosis (TB). Until now, most of the focus in the TB field has been on MTBC L2 and L4, as these two lineages are geographically widespread and have been repeatedly as…
Emily Lai-Ho MacLean, Kyung Hyun Oh, Kalpeshsinh Rahevar, Carl-Michael Nathanson, Alexei Korobitsyn, et al.
**BACKGROUND:** Timely, accurate tuberculosis (TB) diagnostics and strong laboratory networks are critical for providing high-quality TB care. In the Western Pacific Region, available resources, TB burdens, and access to TB testing vary dramatically between countries. To understa…
Susanna Esposito, Beatrice Rita Campana, Gaia Giorgia Arnesano, Nicola Principi
Tuberculosis (TB) remains a leading cause of morbidity and mortality worldwide, with children representing a particularly vulnerable population in whom diagnosis is often challenging. Pediatric TB is typically paucibacillary and presents with non-specific clinical manifestations,…
Kyung Hyun Oh, Alvin Kuo Jing Teo, Manami Yanagawa, Avinash Kanchar, Dennis Falzon, et al.
**BACKGROUND:** Tuberculosis preventive treatment (TPT) can avert progression from infection to disease, yet scale-up across the World Health Organization Western Pacific Region is patchy. To guide acceleration, we assessed progress, challenges and responses in seven high-burden …
Kohei Kamegai, Ikumi Ono, Sayaka Kageyama, Kotaro Murata, Shunta Miura, et al.
In December 2024, Japan's Pre-Entry Tuberculosis Screening (JPETS) program was introduced in coordination with the Ministry of Health, Labour and Welfare (MHLW), the Ministry of Foreign Affairs, and the Immigration Services Agency to mandate tuberculosis (TB) screening for mid- t…
Salma Madihi, Achraf Aainouss, Mly Driss Ei Messaoudi, Abdelouaheb Benani
Tuberculosis (TB) is a major health burden, the leading cause of death among people living with HIV, and one of the main causes of death linked to antimicrobial resistance. The World Health Organization (WHO) launched in 2015 the End TB Initiative that aims to reduce TB cases and…
Yi Hao Wong, Hai Tarng Chong, Ting Huey Hu, Catherine Wei Min Ong
Despite the World Health Organization End TB Strategy, tuberculosis (TB) remains the world's leading infectious cause of death. Conventional antimicrobial therapies are hindered by prolonged treatment durations, poor patient adherence, and drug toxicity. Host-directed therapies (…
María Belén Vecchione, Denise Anabella Giannone, Milagros Victoria Acevedo, Natalia Santucci, Maria Florencia Quiroga
**BACKGROUND:** Tuberculosis (TB) remains a leading cause of mortality worldwide among infectious agents, and HIV increases the risk of developing into active disease. HIV-TB coinfection impairs immune responses, while chronic inflammation and infection-associated stress activate…
Salvatore Rotundo, Francesca Serapide, Gabriella d'Ettorre, Maria Teresa Tassone, Mattia Albanese, et al.
Tuberculosis (TB) remains a significant global health challenge, especially in countries with low TB incidence, exacerbated by the influx of migrants from high TB-burden regions. This paper reviews the challenges and strategies for managing TB infection (TBI) among migrants. Chal…
Yonathan William, Marto Sugiono, Patricia Diana Prasetiyo, Adelbertus Erico, Gilbert Sterling Octavius
…d tuberculous prostatitis. The patient was treated with antituberculosis drugs, resulting in symptomatic improvement and a significant PSA decline. This case highlights the diagnostic challenge of distinguishing tuberculous prostatitis from prostate cancer, particularly in tuberc…
Francesca Saluzzo, Andrea Maurizio Cabibbe, Richard Anthony, Alexandra Aubry, Francis Drobniewski, et al.
…rted poor treatment outcomes for extensively drug-resistant tuberculosis (TB) in the European region highlight the urgent need for effective and context-appropriate diagnostic strategies. While the World Health Organisation (WHO) provides model algorithms, these require adaptatio…
Aishwarya Venkataraman, Nancy Hilda Joseph, Gopika Sadanandan, S Balasubramanian
Clinical research involving children presents significant challenges due to physiological, ethical, regulatory, and practical considerations unique to this vulnerable population. These intrinsic challenges were amplified during the COVID-19 pandemic, which substantially disrupted…
Anna Starshinova, Ekaterina Belyaeva, Olga Irtyuga, Giunai Sefiyeva, Lubov Mitrofanova, et al.
Tuberculosis remains a serious infectious disease that causes over 1.3 million deaths annually. Following the COVID-19 pandemic, the global incidence of tuberculosis has increased to 10.8 million cases. Pregnant women represent a particularly vulnerable population requiring tailo…
Siddharth Sekhar Sethy, Gagan Deep, P V Sudhakar, Tarun Goyal, Pankaj Kandwal, et al.
…cases of extrapulmonary TB. The incidence of osteoarticular tuberculosis is one of the lowest in extrapulmonary tuberculosis, probably only next to cutaneous tuberculosis in non-HIV patients. Considering the low incidence of primary osteoarticular tuberculosis without pulmonary t…