Showing 1–25 of 200 documents
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Seo WJ, Koo HK, Kang JY, Kang J, Park SH, et al.
…ackground The Center for Personalized Precision Medicine of Tuberculosis (cPMTb) was constructed to develop personalized pharmacotherapeutic systems for tuberculosis (TB). This study aimed to introduce the cPMTb cohort and compare the distinct characteristics of patients with TB,…
Luo Y, Xue Y, Tang G, Lin Q, Song H, et al.
Background Novel approaches for tuberculosis (TB) diagnosis, especially for distinguishing active TB (ATB) from latent TB infection (LTBI), are urgently warranted. The present study aims to determine whether the combination of HLA-DR on Mycobacterium tuberculosis (MTB)-specific c…
Barik BS, Kar CD, Das S, Hussain T, Nayak S, et al.
Introduction Contacts of tuberculosis (TB) patients have an increased risk of latent TB infection (LTBI). Currently, it is diagnosed using one of the two methods: Tuberculin skin test (TST) or QuantiFERON-TB Gold Plus. This study aims to estimate the concordance of TST and QFT-TB…
Mao L, Xu L, Wang X, Du J, Sun Q, et al.
… expressed over the reactivation from dormant Mycobacterium tuberculosis (M. tuberculosis) could be used to diagnose tuberculosis (TB) at different stages. We performed a retrospective cohort study based on four groups, including healthy controls (HCs), active tuberculosis infect…
Cole B, Nilsen DM, Will L, Etkind SC, Burgos M, et al.
This report provides an introduction and reference tool for tuberculosis (TB) controllers regarding the essential components of a public health program to prevent, control, and eliminate TB. The Advisory Council for the Elimination of Tuberculosis and the National Tuberculosis Co…
М. А. Плеханова, В. А. Аксенова, Л. А. Кривцова
…ctive: to determine predictors of the development of latent tuberculosis infection (LTBI) and tuberculosis in children and adolescents. Subjects and methods . A study was carried out, including testing induced IFN-y and assessment of genotypes of the polymorphic variant of IFNG g…
Krunal Patel, Kinjal Patel, Pooja Gandhi, Bhavini Rathwa, Dipak M. Nakum
Introduction: Tuberculosis is a chronic infectious disease caused by predominantly Mycobacterium tubercle bacilli. Pediatric tuberculosis is among the top 10 causes of death in children. India accounts for one fourth of the global tuberculosis burden, standing one among the thirt…
Zhang L, Ma H, Wan S, Zhang Y, Gao M, et al.
Background Differential diagnosis of active tuberculosis (ATB) and latent tuberculosis infection (LTBI) has been a challenge for clinicians in high TB burden countries. The purpose of this study was to improve the accuracy of differential diagnosis of ATB and LTBI by using fluore…
Holmberg P, Janoušková M, Schmidt T, Neumann A, Olsson O, et al.
Background Interferon-γ release assays (IGRAs) for tuberculosis infection (TBI) cannot distinguish different stages of the TBI spectrum (including spontaneously cleared infection). We investigated patterns of Mtb-specific blood mediators in people with and without TBI during tube…
Pan SW, Su WJ, Chan YJ, Chuang FY, Feng JY, et al.
Objectives The timely diagnosis of pulmonary tuberculosis (PTB) is challenging. Although pathogen-derived circulating cell-free DNA (cfDNA) has been detected in humans, the significance of Mycobacterium tuberculosis (MTB)-cfDNA detection in patients with PTB remains unclear. Meth…
Dekel Shlomi, Inbal Galor, Anna More, Bernice Oberman, Lizi Fireman
<b>Background:</b> Treatment for latent tuberculosis (TB) is traditionally based on the result of the tuberculin skin test (TST) which is often falsely positive. The Interferon gamma release assays (IGRA) are more specific but considerably more expensive. Several studies have imp…
Lifan Zhang, Huimin Ma, Qiping Ge, Yueqiu Zhang, Xiaochun Shi, et al.
Abstract Background To establish the Mycobacterium tuberculosis (MTB) specific IFN-γ/IL-2/TNF-α-FluoroSpot assay, and preliminarily evaluate its accuracy of differential diagnosis of active tuberculosis (ATB) and latent tuberculosis infection (LTBI). Methods Patients with patholo…
Luo Y, Xue Y, Mao L, Lin Q, Tang G, et al.
…ackground Rapid and effective discrimination between active tuberculosis (ATB) and latent tuberculosis infection (LTBI) remains a challenge. There is an urgent need for developing practical and affordable approaches targeting this issue. Methods Participants with ATB and LTBI wer…
Luo Y, Xue Y, Yuan X, Lin Q, Tang G, et al.
… is no rapid and effective method for distinguishing active tuberculosis (ATB) from latent tuberculosis infection (LTBI), the discrimination between these two statuses remains challenging. This study sought to investigate the value of nutritional indexes and tuberculosis-specific…
Zhang L, Li Y, Zou X, Ma H, Gao M, et al.
…aims to evaluate the diagnostic accuracy of a Mycobacterium tuberculosis (MTB)-specific triple-color FluoroSpot assay (IFN-γ/IL-2/TNF-α) in the differentiation of tuberculosis (TB) infection status in febrile patients. Method Febrile patients with suspected active TB (ATB) were c…
Teklu T, Wondale B, Taye B, Hailemariam M, Bekele S, et al.
Background Tuberculosis (TB) is one of the world's most problematic infectious diseases. The pathogen Mycobacterium tuberculosis (Mtb) is contained by the immune system in people with latent TB infection (LTBI). No overt disease symptoms occur. The environmental and internal trig…
Karaca C, Ozer F, Sevim DG, Erdoğan O, Unlu M
We present a case series of eight patients with ocular tuberculosis (OTB), latent tuberculosis (TB) or sarcoidosis, some of whom were receiving anti-tumor necrosis factor alpha (anti-TNF-α) therapy for various systemic diseases. Only one patient had a positive QuantiFERON®-TB tes…
Goletti D, Delogu G, Matteelli A, Migliori GB
…arter of the global population is infected by Mycobacterium tuberculosis (Mtb). A better control of tuberculosis (TB) is based on the ability to detect Mtb infection, identifying the progressors to TB disease, undergoing to preventive therapy and implementing strategies to regist…
Luo Y, Tang G, Lin Q, Mao L, Xue Y, et al.
Objectives Distinguishing between active tuberculosis (ATB) and latent tuberculosis infection (LTBI) remains challenging. Methods The modified T-SPOT.TB assay was performed in 499 participants (243 ATB and 256 LTBI) and another 322 participants (162 ATB and 160 LTBI) who were dia…
Luo Y, Xue Y, Lin Q, Tang G, Yuan X, et al.
Background Discriminating active tuberculosis (ATB) from latent tuberculosis infection (LTBI) remains challenging. This study aimed to investigate a diagnostic model based on a combination of iron metabolism and the TB-specific antigen/phytohemagglutinin ratio (TBAg/PHA ratio) in…
Arroyo L, Marín D, Franken KLMC, Ottenhoff THM, Barrera LF
Background Tuberculosis (TB) remains one of the most deadly infectious diseases. One-third to one-fourth of the human population is estimated to be infected with Mycobacterium tuberculosis (Mtb) without showing clinical symptoms, a condition called latent TB infection (LTBI). Dia…
Benachinmardi K, Sampath S, Rao M
Background : Detection of latent tuberculosis infection (LTBI) in children, exposed to tuberculosis (TB) infections, followed by appropriate treatment, could be instrumental in reducing TB burden. Interferon Gamma release assays (IGRA) have higher specificity than tuberculin skin…
Gong W, Wu X
As an ancient infectious disease, tuberculosis (TB) is still the leading cause of death from a single infectious agent worldwide. Latent TB infection (LTBI) has been recognized as the largest source of new TB cases and is one of the biggest obstacles to achieving the aim of the E…
Kapata N, Tembo J, Mwaba P, Nabyonga-Orem J, Ntoumi F, et al.
Tuberculosis (TB) remains a leading cause of morbidity and mortality in Africa, with latent TB infection (LTBI) and TB co-infections posing significant public health challenges. This viewpoint examines the undiagnosed burden of LTBI and TB co-infections across the continent, emph…
Kamolratanakul S, Ariyanon W, Udompornpitak K, Bhunyakarnjanarat T, Leelahavanichkul A, et al.
…r how the immune system controls the transition from latent tuberculosis (TB) infection (LTBI) to active pulmonary infection (PTB). Here, we applied mass spectrometry cytometry time-of-flight (CyTOF) analysis of peripheral blood mononuclear cells to compare the immunological land…