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Inbaraj LR, Manesh A, Ponnuraja C, Bhaskar A, Srinivasalu VA, et al.
… up for 1 year after the treatment. DISCUSSION: Current WHO regimens have agents with poor central nervous system drug exposure and is too long. It does not reflect the accumulating evidence in the field. We propose a comprehensive clinical trial incorporating the emerging eviden…
Xueyi Chen, Carlos E Ruiz-Gonzalez, Yuderleys Masias-Leon, Mantej Singh, Oscar J Nino-Meza, et al.
…ains unexplored.Figure 1.Evaluation of rifamycin-containing regimens in the mouse model of TB meningitis.(A) Mice were infected intraventricularly via Burr hole using a syringe and stereotaxic instrument, treatment were initiated two weeks after (designated as day 0) and continue…
Xinxin Zeng, Hao Xu, Aole Li, Juanjuan Liu, Yuhang Wu, et al.
…for childhood tuberculosis (TB), evaluation of TB treatment regimens for children in real-world settings in China remained limited, particularly regarding treatment duration, utilization of second-line anti-TB drugs (SLDs), and adverse events. This study aimed to describe the tre…
Sulis G, Tavaziva G, Gore G, Benedetti A, Solomons R, et al.
…mide (2HRZE/10HR). The comparative effectiveness of shorter regimens is unknown. Methods To inform a WHO guideline update, we undertook a systematic review and meta-analysis to evaluate outcomes from regimens of 6- to less than 12-months' duration that included, at a minimum, iso…
Camilo A. Ruiz-Bedoya, Filipa Mota, Elizabeth W. Tucker, Farina J. Mahmud, Clara Erice, et al.
…atment in animals receiving high- or standard-dose rifampin regimens (Fig. 3). Whole-brain PET and immunolabeling demonstrated spatially compartmentalized inflammation, vascular leak and rifampin exposures (Fig. 4). Longitudinal imaging in the same animals showed a 40% decrease i…
Wasmann RE, Masini T, Viney K, Verkuijl S, Brands A, et al.
Following infection with Mycobacterium tuberculosis , young children are at high risk of developing severe forms of tuberculosis (TB) disease, including TB meningitis (TBM), which is associated with significant morbidity and mortality. In 2022, the World Health Organization (WHO)…
Ruiz-Bedoya C, Mota F, Tucker E, Mahmud F, Erice C, et al.
Abstract Background TB meningitis is the most severe form of tuberculosis (TB), associated with high morbidity and mortality. High-dose rifampin (35mg/kg/day) is safe in adults and substantially improves the bactericidal activity of standard TB regimen. However, there is conflict…
Mengmeng Zhang, Ming-Gui Wang, Jian‐Qing He
Background Tuberculous meningitis is difficult to diagnose and is associated with high mortality. Recently, several studies evaluated the intensified regimen containing higher dose rifampin to treat tuberculous meningitis. However, this topic remains to be concluded. Therefore, t…
Eliana Bicudo, Naira Bicudo, Clarisse Rocha, Joyce Cabral, Gustavo Bicudo
…se infections can be complex, requiring combined antibiotic regimens, oral and intravenous, for prolonged periods, and antimicrobial resistance often poses a challenge. Outpatient Parenteral Antimicrobial Therapy (OPAT) has proven to be an effective approach, allowing patients to…
Aryal A, Garg B, Mehta N, Shekhar S, Gupta V
…rity in the healing response achieved compared to treatment regimens of longer duration.
Svetlana Degtyareva, Т. А. Кузнецова, В. Н. Зимина
…case demonstrates the clinical efficacy of modern treatment regimens, good compatibility with other drugs and management of adverse events without treatment interruption.
Connie A. Haley, David Ashkin, Charles A. Peloquin
…quires prolonged treatment using less effective, more toxic regimens. Recent trials demonstrated that the all-oral six-month “BPaL” regimen, Bedaquiline, Pretomanid and Linezolid, is 90% effective. In these trials, linezolid-induced hematologic and neurologic toxicity was high us…
…quires prolonged treatment using less effective, more toxic regimens. Recent trials demonstrated that the all-oral six-month “BPaL” regimen, Bedaquiline, Pretomanid and Linezolid, is 90% effective. In these trials, linezolid-induced hematologic and neurologic toxicity was high us…
Xueyi Chen, Carlos E Ruiz-Gonzalez, Yuderleys Masias-Leon, Medha Singh, Charles A Peloquin, et al.
Tuberculous meningitis causes substantial mortality due to limited penetration of antibiotics to the central nervous system and excessive neuroinflammation. This study evaluated clofazimine as an adjunct to the standard first-line tuberculosis regimen, in a mouse model. Mice were…
M. V. S. Subbalaxmi, Suneel Kumar Bagadi, Sandeep Baddepuram, Radhika Soanker
Stevens–Johnson syndrome (SJS) and hepatitis are serious adverse drug reactions following the administration of anti-tuberculosis treatment (ATT). Here, we report a case of a young woman who developed hepatitis and SJS following ATT. Identifying the culprit drug and tailoring the…
Johan Benhard, Gentiane Monsel, Vincent Dubée, Patricia Pavese, Vero Rasoldier, et al.
**BACKGROUND:** Morbidity associated with central nervous system tuberculosis (CNS TB) remains high due to persistent inflammation despite standard-of-care (SOC) treatment, including antituberculosis therapy and corticosteroids. Tumor necrosis factor alpha (TNF-α) is a key …
Saluja A, Vibha D, Pandit AK, Shukla G, Srivastava AK, et al.
Introduction Corticosteroids are used as adjunctive treatment in tuberculous meningitis (TBM). However, there is no universally accepted regimen, type, duration, or route of steroid administration. Methodology In a randomized open labelled pilot study, TBM patients were divided i…
Kumar RNH, Rao CR, Maradi R, Umakanth S, Sanju SVC, et al.
Aim The study aimed to determine the incidence of adverse drug reactions (ADRs) among newly diagnosed tuberculosis (TB) patients receiving daily drug regimen with fixed-dose combination treatment under the National Tuberculosis Elimination Program. Materials and methods A communi…
Li Z, Wang S, Chen X, Ming X, Peng L, et al.
Despite the high prevalence of pulmonary tuberculosis worldwide, extrapulmonary tuberculosis especially cutaneous and osteoarticular tuberculosis occurs rarely, both of which are often difficult to be recognized since their symptoms mimic those of many other cutaneous and osteoar…
Surendra Kumar Sharma, Vishwanath Upadhyay, Alladi Mohan
…12 months after culture conversion45. Suggested antibiotics regimens for adults with MAB-pulmonary disease have been adequately described previously in the guidelines459. Expert consultation should be obtained while treating MAB45. Treatment for clarithromycin-sensitive MAB-pulmo…
Xueyi Chen, Carlos E Ruiz-Gonzalez, Yuderleys Masias-Leon, Medha Singh, Oscar J Nino-Meza, et al.
…men, and retrospective studies showing that rifabutin-based regimens are effective and well-tolerated, both drugs still need dedicated evaluation in TB meningitis. **METHODS:** Mice were intracranially inoculated with Mycobacterium tuberculosis and treated with rifamycin (rifamp…
Radisic MV, Pujato NR, Bravo PM, Del Grosso RC, Hunter M, et al.
…rom other populations or observational. Rifampin-containing regimens have strong pharmacokinetic interactions with immunosuppressive regimens, with high rates of organ dysfunction and ∼20% mortality. This report describes the results obtained using non-rifampin-containing regimen…
Colette Biro, Corinne Muirhead
…ilities and provider experience facilitate chosen treatment regimens. MABSC infections are difficult to treat due to intrinsic and acquired resistance patterns, limited oral antibiotic options, and medication toxicity.2 Optimal treatment duration is not known and people who do no…
Heather Wang, Mohammad Mahdee Sobhanie, Courtney Nichols
…. Breakdown of antibiotic classes used in initial treatment regimens for dNTM-infected patients, along with antibiotics that caused patient intolerances. For each antibiotic class that caused intolerance, average time to develop intolerance listed. Conclusion Treatment of dissemi…
Rizvi I, Malhotra HS, Garg RK, Kumar N, Uniyal R, et al.
…iew summarizes the effects of fluoroquinolone in first line regimens in tuberculous meningitis. Methods A systematic search of literature was performed using PubMed, Cochrane Central Register of Controlled Trials (CENTRAL) and LILACS for articles published till march 2017. We als…