Showing 1–25 of 200 documents
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Inna Friesen, Timo Ulrichs, L. A. Hryshchuk, H. S. Saturska
Objective — to compare the epidemiological situation of chemoresistant tuberculosis in Germany and Ukraine, in addition analyzing the nature and features of chemoresistant tuberculosis in 192 patients treated at the Ternopil Regional TB Dispensary Ukraine during 2017—2018.
 …
Chisompola NK, Streicher EM, Muchemwa CMK, Warren RM, Sampson SL
… drug resistance AND Africa AND (spoligotyping OR molecular epidemiology OR IS6110 OR MIRU OR DNA fingerprinting OR RFLP OR VNTR OR WGS)" were used to identify relevant articles reporting the molecular epidemiology of drug resistant TB in Africa. Results Diverse genotypes are ass…
Xu Y, Li Q, Zhu M, Wu X, Wang D, et al.
The aim of this study was to investigate the epidemiological characteristics and profile of drug-resistant tuberculosis (DR-TB) among children with TB in Sichuan province of China.From January 2015 to December 2018, microbiological culture-confirmed child TB cases (aged <15 years…
Che Y, Li X, Chen T, Lu Y, Sang G, et al.
…ealth concern in Ningbo, China. Understanding its molecular epidemiology and spatial distribution is paramount for effective control. Methods From December 24, 2020, to March 12, 2023, we collected clinical Mycobacterium tuberculosis (MTB) strains in Ningbo, with whole-genome seq…
Loukman M, Olivier B, Vincent B, Rachid D, Cyril F, et al.
…nual deaths for 10 million cases. Little is known about the epidemiology of tuberculosis and its resistance in Reunion Island, which is at the heart of migratory flows from highly endemic Indian Ocean territories. Methods We carried out a retrospective observational study of case…
Olha Konstantynovska, Oleksandr Liashenko, Petro Poteiko, Anton Rohozhyn, Ivan Hrek, et al.
Ukraine ranks fourth globally with the highest number of MDR (multiple drug resistant) and XDR (extensively drug resistant) TB cases in the world. Recent study showed M. tuberculosis isolates were as high as 35% XDR in Ukraine, and the most common strains among the XDR-TB are due…
Sora Yasri, Viroj Wiwanitkit
… of extensively drug-resistant M. tuberculosis. The genetic epidemiology study on the extensively drug-resistant M. tuberculosis isolate can provide helpful data for local public health planning. Here, the authors reappraise on the available data[34] on molecular epidemiology of …
Xiaoyu Lu, Yuan Jiang, Yanping Liu, Junhong Chen, Yinglin Lao, et al.
Tuberculosis (TB), particularly extremely drug-resistant TB (EDR-TB), remains a significant public health concern worldwide. Understanding the transmission patterns and epidemiological characteristics of EDR-TB is vital for effective disease control. Between 1 January 2006 and 31…
Mizukoshi F, Kobayashi N, Kirikae F, Ohta K, Tsuyuguchi K, et al.
…operties of drug-resistant tuberculosis in Japan. Molecular epidemiology provides several clues to inform potential measures to control drug-resistant tuberculosis in Japan.
Dzeyie KA, Basu S, Dikid T, Bhatnagar AK, Chauhan LS, et al.
Background Multidrug-resistant tuberculosis (MDR-TB) is a major public health challenge in India. It is associated with poor treatment outcomes, multiple adverse effects to treatment and involves enormous social and economic losses. The objective of the study was to ascertain the…
Tiberi S, Utjesanovic N, Galvin J, Centis R, D'Ambrosio L, et al.
…eview is to inform the reader on the latest developments in epidemiology, diagnostics and management. Epidemiology Drug-resistant Tuberculosis (DR-TB) continues to be a current global health threat, and is defined by higher morbidity and mortality, sequelae, higher cost and compl…
Dohál M, Dvořáková V, Šperková M, Porvazník I, Cabibbe AM, et al.
Objective The resistance of Mycobacterium ( M. ) tuberculosis to antituberculosis drugs poses a major threat to global public health. Whole genome sequencing (WGS) is an increasingly preferred method in the diagnostics and monitoring of the transmission dynamics of resistant form…
Lei Ji, Feilin Ren, Deshun Xu, Xiaohua Zhu, Zhaowei Tong, et al.
…SNP threshold) were conducted to characterize the molecular epidemiology of TB in this region. **RESULTS:** Lineage 2.2.1 (Beijing genotype) was predominant (80.0%). A total of 86 isolates (24.6%) harbored drug resistance-associated mutations, including 2.0% MDR-TB and 1.7% pre-…
Mandlenkosi Manika, Lindiwe Modest Faye, Ntandazo Dlatu, Mojisola Clara Hosu
…ssion of resistance-associated genetic mutations. Molecular epidemiology provides critical insights into mutation profiles and resistance associations, yet the interplay among key mutations and their contributions to complex resistance patterns remains poorly understood, particul…
Neelima Sharma, Arjun Khanna, Shivani Chandra, Saurav Basu, Kanwaljit Chopra, et al.
Background: Multidrug-resistant tuberculosis (MDR-TB) referring to tuberculosis that is resistant to both rifampicin and isoniazid is a major challenge against meeting TB elimination targets. We conducted this operational research study with the objective of describing MDR-TB tre…
Bhering M, Kritski A
This study aimed to reinforce the importance of the epidemiological surveillance of multidrug-resistant tuberculosis (MDR-TB) in Rio de Janeiro State (RJ). Here, we reviewed seven articles we published between 2018 and 2022. This study had two phases. The quantitative phase where…
Fariza Fadzil, S R Ramli, Hui‐min Neoh
…s the timeline of pulmonary tuberculosis (PTB) in Malaysia, epidemiology, management and outlook of the disease in the country. PTB was first reported in Malaya in the early 20th century and caused high morbidity and mortality. With the establishment of the National TB Control Pr…
Kamonnut Singkhamanan
Pseudomonas aeruginosa (n = 112) isolates from various clinical specimens of hospitalized patients in Songklanagarind Hospital, southern Thailand from February 2012 to January 2013 were analyzed for susceptibility to 10 different antibiotics using a disk diffusion method and gene…
Kumari Neelam, Ira Sharma, Devinder Kumar, Kunal Goel, Virender Singh, et al.
…ummarizes the latest developments in the field, focusing on epidemiology, pathogenesis, diagnostic innovations, novel anti-tuberculosis drugs, combination therapy approaches, surgical interventions, adjunctive therapies, and the importance of multidisciplinary approaches. Emergin…
M. Kumar, Sonam Sharma
…ering aspects such as transmission, pathogenesis, worldwide epidemiology, diagnostic methods, treatment protocols, drug resistance, preventive measures, and current research endeavours. Focus is directed towards innovative molecular diagnostics, the incorporation of artificial in…
Riccardi N, Pontarelli A, Alagna R, Saderi L, Ferrarese M, et al.
Objective We evaluated the epidemiology and treatment outcomes of multi-drug-resistant (MDR) and pre-extensively-resistant (pre-XDR) tuberculosis (TB) in migrants at two TB reference centers in Italy. Study design Patient selection criteria for the present study were as follows: …
Sonia Islam Khan
… narrative review explores the current understanding of the epidemiology, clinical features, diagnostic approaches, and challenges related to treatment failure in TB. Globally, an estimated 10 million new TB cases and 1.3 million TB-related deaths were reported in 2022, with the …
Medina
With 5,000 new active cases each year, tuberculosis in Chile remains as the most important communicable disease in the country. Since the type of control programs are linked to the epidemiologic situation as far as infection, morbidity and mortality are concerned, an effective su…
Couvin D, Reynaud Y, Rastogi N
The East African Indian (EAI) and Central Asian (CAS) lineages of Mycobacterium tuberculosis complex (MTBC) mainly infect tuberculosis (TB) patients in the eastern hemisphere which contains many of the 22 high TB burden countries including China and India. We investigated if phyl…
Neel R Gandhi, Kogieleum Naidoo, Keeren Lutchminarain, Shaheed V Omar, Hikari Yoshii, et al.
**RATIONALE:** Transmission is the primary driver of tuberculosis (TB) and drug-resistant (DR) TB in high-burden countries; however, where and between whom spread occurs is poorly understood. **OBJECTIVE:** We conducted universal whole genome sequencing (WGS) to evaluate the rol…