Showing 1–25 of 200 documents
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Rabaan AA, Mutair AA, Albayat H, Alotaibi J, Sulaiman T, et al.
… either asymptomatic or not diagnosed, and the frequency of drug resistance is increasing due to intrinsically linked factors from both host and bacterium. For instance, poor access to TB diagnosis and reduced treatment in the era of the COVID-19 pandemic has resulted in more TB …
Imtiaz Pasha, Ashraf ALakkad
Background: Drug-resistant tuberculosis (DR-TB) poses significant challenges to public health, with poor outcomes frequently observed in affected patients. This study aims to evaluate the characteristics and factors associated with poor outcomes in patients with drug-resistant pu…
Valdez-Palomares F, Muñoz Torrico M, Palacios-González B, Soberón X, Silva-Herzog E
… diversity and composition of the respiratory microbiome of drug-resistant and drug-sensitive tuberculosis patients as well as healthy volunteers. Tuberculosis patients exhibited increased microbial diversity and differentially abundant bacteria than healthy volunteers. Compositi…
S. Lakshmi Kumari, Srikanti Raghu, Karri Maruthi Devi, AswinaTripura Sundari, D Sudheer, et al.
…H) is one of the most important first-line antituberculosis drugs used for the treatment of active tuberculosis (TB) and latent TB infection (LTBI) with high bactericidal activity and a good safety profile. The emergence of TB strains resistant to isoniazid threatens to reduce th…
Elisa H Ignatious, Susan Swindells
…easingly available across the spectrum of TB, including for drug-resistant TB. Simultaneous treatment of HIV and TB is complicated by drug-drug interactions, although trials are ongoing to better understand the magnitude of these interactions and guide clinicians in how to use sh…
Ignatious EH, Swindells S
…easingly available across the spectrum of TB, including for drug-resistant TB. Simultaneous treatment of HIV and TB is complicated by drug-drug interactions, although trials are ongoing to better understand the magnitude of these interactions and guide clinicians in how to use sh…
Alimuddin Zumla, Jeremiah Chakaya, Mishal Khan, Razia Fatima, Christian Wejse, et al.
…cluding provision of more rapid and complete information on drug-resistance, detection of transmission clusters, contamination events, mixed infections, and to differentiate between re-infection and relapse. They also discuss future advances that have the potential to change the …
E Kırımi, Jeconiah A. Okelo, Mark Kimathi, Kenneth Ngure
…s and pneumonia co-infection is formulated, incorporating a drug-resistant strain. The model employs a Holling-type functional response to capture the impact of natural immunity on the progression from latent tuberculosis infection to active disease, as well as its role in contro…
Perveen S, Negi A, Saini S, Gangwar A, Sharma R
…ed bacterial targets is a prerequisite to combat increasing drug resistance against Mycobacterium tuberculosis . This study employed a whole-cell screening approach as an initial filter to scrutinize a 10,000-compound chemical library, resulting in the discovery of seven potent c…
Seeberg J
…access to treatment has had the unintended consequence that drug-resistant TB (DR-TB) has increased dramatically. Earlier TB control strategies strongly emphasizing medical treatment have failed to address these issues effectively. The current strategy to eliminate TB by 2050 is …
Khan MT, Kaushik AC, Bhatti AI, Zhang YJ, Zhang S, et al.
Pyrazinamide (PZA) is the only drug for the elimination of latent Mycobacterium tuberculosis (MTB) isolates. However, due to the increased number of PZA-resistance, the chances of the success of global TB elimination seems to be more prolonged. Recently, marine natural products (…
Shleider Carnero Canales C, Marquez Cazorla J, Furtado Torres AH, Monteiro Filardi ET, Di Filippo LD, et al.
… in addition to traditional first-line therapies, anti-LTBI drugs, anti-resistant TB drugs, and innovative candidates in preclinical and clinical stages are being explored. Although the advancements are promising, it is crucial to recognize that further research and clinical evid…
Zelalem Temesgen, Daniela María Cirillo, Mario Raviǵlione
…nd facilitation of rapid expansion at the population level. Drug-resistance is an emerging crisis for which appropriate diagnostic tools are either unavailable or inadequate. Conventional phenotypic drug-susceptibility testing can identify only low numbers of resistance mutations…
Khan MT, Khan A, Rehman AU, Wang Y, Akhtar K, et al.
Resistance to key first-line drugs is a major hurdle to achieve the global end tuberculosis (TB) targets. A prodrug, pyrazinamide (PZA) is the only drug, effective in latent TB, recommended in drug resistance and susceptible Mycobacterium tuberculosis (MTB) isolates. The prodrug …
Jerome Manzano, Lerma Bhelle B Iglesia, Vikki Darl R Rodriguez, Julius Patrick R Miranda, Regina Berba
…Isoniazid is used in short course second line treatment for drug resistant tuberculosis. It is not only needed for the treatment of active tuberculosis but also highly effective in preventing disease and for latent TB infection. However, isoniazid resistance is regarded to underm…
Li TL, Chan TH, Chenghui Wang, Jou R, Yu Mc, et al.
… cough and was found to harbor active TB disease with added resistance to isoniazid. An individualized anti-TB regimen consisting of moxifloxacin, kanamycin, prothionamide, ethambutol, and pyrazinamide was prescribed for 20 months, leading to sputum culture conversion and improve…
Geberetsadik G, Inaizumi A, Nishiyama A, Yamaguchi T, Hamamoto H, et al.
…at. There is an urgent need to develop new antituberculosis drugs with novel modes of action to cure drug-resistant tuberculosis and shorten the chemotherapy period by sterilizing tissues infected with dormant bacteria. Lysocin E is an antibiotic that showed antibacterial activit…
Xin Zhang, Ruixia Zhao, Yao Qi, Xiong Yan, Gaoxiu Qi, et al.
…regimen has a long treatment cycle and is prone to multiple drug resistance. Anti-tuberculosis drugs and latent tuberculosis infection (LTBI) resistance are increasing year by year, and new targets and new bioactive compounds are urgently needed to treat this disease. This review…
Samuelk Paul
…ad use of molecular technology and the rapid assessment for drug resistance using nucleic acid amplification testing has greatly enhanced the diagnosis of smear-positive and smear-negative TB. To this end, the International Standards for Tuberculosis Care have been updated and of…
Ananthi Rajendran, Ahmed Kabir Refaya, Balaji Subramanyam, Ramesh Karunaianantham, Dhandapani RaviKumar, et al.
…nt tuberculosis, particularly in regimens designed to treat drug-resistant TB. However, diagnosing resistance to PZA poses challenges for managing TB, highlighting the need for accurate detection methods. This study aims to address the challenges in detecting PZA resistance by mo…
Pahuja I, Verma A, Ghoshal A, Mukhopadhyay S, Kumari A, et al.
…use of antibiotics have resulted in the emergence of deadly drug-resistant variants of Mycobacterium tuberculosis ( M.tb ). This study aims to characterize the functionality of the carbapenem antibiotic-Biapenem (BPM) in generating long-lasting immunity against TB. BPM treatment …
Anjana Dogra, Sheetal Agarwal
…ficulty in specimen collection and increasing prevalence of drug-resistant TB. Recent advances in diagnostics, therapeutics and preventive strategies have transformed the management of TB in children. Methods: This narrative review summarises recent evidence, World Health Organis…
Yu Y, Jiang XX, Li JC
…s in which its pathogen Mycobacterium tuberculosis (Mtb) is drug resistant has been increasing worldwide, whereas latent tuberculosis infection (LTBI) may develop into active TB. Thus it is important to understand the mechanism of drug resistance, find new drugs, and find biomark…
Zhang X, Zhao R, Qi Y, Yan X, Qi G, et al.
…regimen has a long treatment cycle and is prone to multiple drug resistance. Anti-tuberculosis drugs and latent tuberculosis infection (LTBI) resistance are increasing year by year, and new targets and new bioactive compounds are urgently needed to treat this disease. This review…
Ketan N Malu, Avinash Lamb
…b>Background:</b> Isoniazid(INH) is an important first line drug in the management of active and latent TB. It’s widespread use and lack of diagnostic testing has resulted in increase in prevalence of Hr-TB, either alone or in combination with other drugs. katG and inhA mutations…