Showing 1–25 of 200 documents
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Muhammad Kashif Munir
…attle against Koch’s disease is still being fought and that diagnostics remain the frontline weapon.1 The history of tuberculosis (TB) diagnostics is, in many ways, the history of microbiology itself. From microscopy and culture to molecular assays capable of detecting resistance…
Adam Penn‐Nicholson, Sophia B. Georghiou, Nelly Ciobanu, Mubin Kazi, Manpreet Bhalla, et al.
Abstract Background The WHO End TB Strategy requires universal drug susceptibility testing and treatment of all people with tuberculosis. However, available second-line diagnostic tools are cumbersome and require sophisticated laboratory infrastructure, and ultimately less than h…
Anaesthesia Technician and Private Practitioner, India, Berlin Francis
… the gap between conventional culture methods and molecular diagnostics, MGIT enhances diagnostic accuracy and supports global TB control strategies. This article explores the role of MGIT systems in tuberculosis detection, examines their contribution in integrating culture-based…
Eskild Petersen, David S.C. Hui, Jean B. Nachega, Francine Ntoumi, Delia Goletti, et al.
…ortant precedent for increasing access to affordable drugs, diagnostics and vaccines for other epidemic diseases affecting resource-poor countries. In April, 2021, a Brazil judge suspended drug patent extensions, a preliminary decision that could lower costs for drugs critical to…
Gayathri Ramasubban, Joy Sarojini Michael, Richa Gupta, Kavyasri Channamaneni, Dhanabagyam Krishnan, et al.
…developed to provide efficient, accurate, and accessible TB diagnostics. This study evaluates the performance of the mfloDx ™ pre-XDR-TB test for detecting TB and drug resistance against MGIT culture and drug susceptibility testing (DST). Methodology We have evaluated the perform…
Yuliya Mikhaylova, Nadezhda Mezentseva, С. А. Стерликов, Aleksandr Mikhaylov, Yana Pankova
Significance. The system of microbiological diagnostics is of key importance for organizing microbiological diagnostics in accordance with the modern recommendations, and fulfilling political commitments of the Russian Federation within the framework of the End TB Strategy Purpos…
Darrel Ornelle Elion Assiana, Franck Hardain Okemba-Okombi, Salomon Tchuandom Bonsi, Freisnel Hermeland Mouzinga, Juliet E Bryant, et al.
National Tuberculosis Reference Laboratories (NTRLs) are central to tuberculosis (TB) control programs. Between 2018 and 2024, the Republic of Congo, a country of 6 million inhabitants, achieved a transformative strengthening of its TB diagnostic system, coordinated by the NTRL. …
Tiberi S, Utjesanovic N, Galvin J, Centis R, D'Ambrosio L, et al.
…form the reader on the latest developments in epidemiology, diagnostics and management. Epidemiology Drug-resistant Tuberculosis (DR-TB) continues to be a current global health threat, and is defined by higher morbidity and mortality, sequelae, higher cost and complexity. The WHO…
Anthony G. Tsolaki, Amy K. Barczak, Uday Kishore
This Research Topic aimed to attract studies that would enhance our understanding of host immunity against TB and its role in both pathogenesis and protection. The submitted papers represent diverse approaches to understanding TB, from biomarker discovery and drug resistance surv…
Mohammadzadeh R, Ghazvini K, Farsiani H, Soleimanpour S
Tuberculosis (TB) is a fatal epidemic disease usually caused by Mycobacterium tuberculosis ( Mtb ). Pervasive latent infection, multidrug- and extensively drug-resistant tuberculosis (MDR- and XDR-TB), and TB/HIV co-infection make TB a global health problem, which emphasises the …
Yingying Yuan, Pengxiang Li, Xiangjie Qiu, Honghua Zhang, Hao Chen, et al.
**OBJECTIVES:** Clinical data on bone and joint tuberculosis (BJTB) in developing countries remain limited. This study aims to investigate the clinical, epidemiological, and drug-resistance characteristics of BJTB patients in Central China and to optimize diagnostic strategies. …
Maya T, Wilfred A, Lubinza C, Mfaume S, Mafie M, et al.
Introduction Early diagnosis of tuberculosis (TB) and universal access to drug-susceptibility testing (DST) are critical elements of the WHO End TB Strategy. Current rapid tests (e.g., Xpert ® MTB/RIF and Ultra-assays) can detect rifampicin resistance-conferring mutations, but ca…
KoziÅska,Monika, Filipczak,Dorota, Augustynowicz-KopeÄ,Ewa
…as obtained. In the course of microbiological and molecular diagnostics, conducted from June 2021 to February 2022, divergent results were obtained from drug susceptibility testing and genotyping of MTB strains isolated from clinical materials from the patient. In the final stage…
Derek T Armstrong, Emma C E Baird, Logan Pretty, Karen D'Agostino, Matthew Schwartz, et al.
Rapid diagnosis of resistance-conferring mutations to antibiotics used for the treatment of tuberculosis (TB) is critical for patient care and public health control efforts. Prior guidelines included the use of fluoroquinolones (FQs) for the treatment of drug-resistant TB, includ…
Kozińska M, Filipczak D, Augustynowicz-Kopeć E
…as obtained. In the course of microbiological and molecular diagnostics, conducted from June 2021 to February 2022, divergent results were obtained from drug susceptibility testing and genotyping of MTB strains isolated from clinical materials from the patient. In the final stage…
Zhang A, Jumbe E, Krysiak R, Sidiki S, Kelley HV, et al.
Background Rural settings where molecular tuberculosis diagnostics are not currently available need easy-to-use tests that do not require additional processing or equipment. While acid-fast bacilli (AFB) smear is the most common and often only tuberculosis diagnosis test performe…
Gupta S, Kakkar V
Early diagnosis and on-time effective treatment are indispensable for Tuberculosis (TB) control - a life threatening infectious communicable disease. The conventional techniques for diagnosing TB normally take two to three weeks. This delay in diagnosis and further increase in de…
Jianguo Shi, Zhengqin Shi, Hao Li, Min Hu, Junbo Nan
Immunosuppression in cancer patients clearly elevates the risk of acquiring tuberculosis (TB) infection, and traditional diagnostic methods are characterized by low sensitivity (Sen) and long turnaround times. Although the interferon-gamma release assay (IGRA) is widely used, its…
Mandira Varma‐Basil, Mridula Bose
Tuberculosis (TB) continues to be a major global health problem despite the fact that with timely diagnosis and appropriate treatment, most patients can be completely cured of the disease. In spite of the availability of an effective treatment regimen, 9.0-11.0 million individual…
Е. М. Жукова, Е. П. Мышкова
…d treatment regimens and express methods of microbiological diagnostics established by the Executive order #951. <b>Methods:</b> The results of treatment of patients (n=378) treated in 2014 and 2018 (years before and after the implementation of the recommendations of WHO, MoH Exe…
Monika Kozińska, Dorota Filipczak, Ewa Augustynowicz-Kopeć
…as obtained. In the course of microbiological and molecular diagnostics, conducted from June 2021 to February 2022, divergent results were obtained from drug susceptibility testing and genotyping of MTB strains isolated from clinical materials from the patient. In the final stage…
Groessl EJ, Ganiats TG, Hillery N, Trollip A, Jackson RL, et al.
…inical settings. We examine the cost-effectiveness of rapid diagnostics for extremely drug-resistant TB (XDR-TB) in three different high-prevalence settings. Methods 1128 patients with confirmed TB were enrolled at clinics in Mumbai, India; Chisinau, Moldova; and Port Elizabeth, …
Kozińska M, Bogucka K, Kędziora K, Szpak-Szpakowska J, Pędzierska-Olizarowicz W, et al.
Drug-resistant TB (DR-TB) in children is a special epidemiological, clinical, and diagnostic problem, and its global incidence remains unknown. DR-TB in children is usually of a primary nature and is most often transmitted to the child from a household contact, so these cases ref…
Yonas Ghebrekristos, Erick Auma, Zama Mahlobo, Rouxjeane Venter, Natalie Beylis, et al.
**UNLABELLED:** Mycobacterium Growth Indicator Tube (MGIT) 960 culture is critical for tuberculosis (TB) drug susceptibility testing (DST) but is vulnerable to contamination. We evaluated the accuracy of Xpert MTB/XDR, a molecular DST for isoniazid, fluoroquinolone, amikacin, and…
Sanchini A, Lanni A, Giannoni F, Mustazzolu A
Despite available global efforts and funding, Tuberculosis (TB) continues to affect a considerable number of patients worldwide. Policy makers and stakeholders set clear goals to reduce TB incidence and mortality, but the emergence of multidrug-resistant TB (MDR-TB) and extensive…