Showing 1–9 of 9 documents
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Mark F. Cotton, Helena Rabie
… control through vaccination remains a global priority. The efficacy of BCG given to neonates to prevent tuberculosis meningitis and miliary tuberculosis is well known.1Trunz BB Fine P Dye C Effect of BCG vaccination on childhood tuberculous meningitis and miliary tuberculosis wo…
Eloise T. M. Filardi, Roberto Carlos Cruz Carbonell, Fernando R. Pavan, Felipe A. Cerni, Manuela B. Pucca
Vaccines represent one of the most significant achievements in medical science, constituting safe preparations or substances developed with the primary purpose of stimulating the immune system (1,2). Their central function is to protect the human body against a myriad of infectio…
Usama Sajjad, Khalid Khan Niazi, Gillian Beamer, Metin N. Gürcan
…over 2 billion individuals worldwide. Although the approved vaccine against TB, <i>M. bovis</i> Bacille Calmette-Guerin (BCG), successfully prevents TB meningitis and systemic TB in children, efficacy against pulmonary TB in adults is highly variable, ranging from 0% to 80…
Nieuwenhuizen NE, Zyla J, Zedler U, Bandermann S, Abu Abed U, et al.
BCG - the only available vaccine against tuberculosis (TB) - was first given to babies 100 years ago in 1921. While it is effective against TB meningitis and disseminated TB, its efficacy against pulmonary TB is variable, notably in adults and adolescents. TB remains one of the w…
Thomas E. Tavolara, Muhammad Khan Niazi, Gillian Beamer, Metin N. Gürcan
…utcomes, vaccination with M. bovis Bacille Calmette-Guerin (BCG) vaccine is used globally in children to prevent systemic disease and tuberculous meningitis. However, in adults, epidemiological studies show variable protection ranging from 0% to 80%. As a part of a larger study t…
D'Auria G, Hodzhev Y, Aceves-Sánchez MJ, Moya A, Panaiotov S, et al.
Background Bacillus Calmette-Guérin (BCG) remains the only vaccine to prevent tuberculosis (TB) during childhood, with relatively low to no efficacy against pulmonary TB in adolescents and adults. BCG consists of close to 15 different substrains, where genetic variations among th…
Videlis Nduba
BCG, the only licensed vaccine against tuberculosis in use today, protects against severe extrapulmonary forms of TB in humans (miliary and meningeal forms), but offers variable protection against the most common respiratory form of the disease (pulmonary TB), with ranges of effi…
Dženan Kovačić, Adna Softić, Adna SALIHOVIĆ, Jovana Jotanović, Sarah Maris Hotić
…numerous reasons for such statistics is the relatively poor efficacy of the near-century-old BCG vaccine. In spite of it being the only approved vaccine for TB, its benefit is predominantly observed in preventing paediatric miliary TB and TB meningitis, whilst it offers considera…
Yang Y, Chen YZ, Xia T
…omplex (MTBC). For a century, the Bacillus Calmette-Guérin (BCG) vaccine has been the primary preventive measure against TB. While it effectively protects against extrapulmonary forms of pediatric TB, it lacks consistent efficacy in providing protection against pulmonary TB in ad…