Showing 176–200 of 200 documents
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Ismail N, Ismail F, Omar SV, Blows L, Gardee Y, et al.
… Strategy targets for 2035 are ambitious and drug resistant tuberculosis is an important barrier, particularly in Africa, home to over a billion people. Objective We sought to review the current status of drug resistant tuberculosis in Africa and highlight key areas requiring imp…
Heidary M, Zaker Bostanabad S, Amini SM, Jafari A, Ghalami Nobar M, et al.
Background Nowadays, tuberculosis (TB) is one of the top ten leading causes of mortality worldwide. The emergence of multidrug-resistant (MDR) - and extensively drug-resistant (XDR) - Mycobacterium tuberculosis (M. tuberculosis) is identified as one of the most challenging threat…
Linnemann LC, Schaible UE, Dallenga TK
Due to the rise of tuberculosis cases infected with multi and extensively drug-resistant Mycobacterium tuberculosis strains and the emergence of isolates resistant to antibiotics newly in clinical use, host-directed therapies targeting pathogenesis-associated immune pathways adju…
Karan Varshney, Frasso, CPh, Rosemary, DrPH Leader, et al.
Tuberculosis killed more people in 2018 than any other single infectious disease. In recent years, there has been an upsurge in cases of drug-resistant tuberculosis. Considering both that antibiotic resistance has been described as a global crisis, and that strains of tuberculosi…
Youngkyoung Lee, Hoonhee Seo, Soyeon Lee, Dongsic Choi, Sukyung Kim, et al.
Tuberculosis remains a severe global health threat, exacerbated by the rising prevalence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis. Despite the urgent need for effective interventions, the development of anti-tuberculosis drugs h…
М. В. Павлова, О. V. Lushina, A. I. Anisimova, Л. И. Арчакова, P. K. Yаblonskiy
… devoted to the effectiveness of the treatment of pulmonary tuberculosis with multiple (MDR) and broad drug resistance (XDR) M. tuberculosis (MBT) in patients after the end of the main course of treatment (intensive and continuation phase), which were observed with clinical cure …
Mohsen Heidary, Saeed Zaker Bostanabad, Amini SM, Ameneh Jafari, Ghalami Nobar M, et al.
…ran, IranEmail davood_darban@yahoo.comBackground: Nowadays, tuberculosis (TB) is one of the top ten leading causes of mortality worldwide. The emergence of multidrug-resistant (MDR) – and extensively drug-resistant (XDR) – Mycobacterium tuberculosis (M. tuberculosis) …
O.B. Pikas, M.A. Semeniuk
…rience and professional publications on modern treatment of tuberculosis patients and its effectiveness was carried out.The analysis of literary sources of recent years indicates an urgent problem regarding tuberculosis in Ukraine (especially in the conditions of martial law and …
A. A. Akzhigitova, T. N. Ignatova, A. К. Konratov, M. В. Теn
…f choice in therapy for extensively and multidrug-resistant tuberculosis. It is indicated for children from a 6-year age and young adults as part of a combination chemotherapy, in compliance with the medical council’s (MC) regulation on active extensively and multidrug-resistant …
Daniyarov A, Akhmetova A, Rakhimova S, Abilova Z, Yerezhepov D, et al.
…kground Kazakhstan has a high burden of multidrug-resistant tuberculosis in the Central Asian region. This study aimed to perform genomic characterization of Mycobacterium tuberculosis strains obtained from Kazakhstani patients with pre-extensively drug-resistant tuberculosis dia…
Sora Yasri, Viroj Wiwanitkit
Emergence of drug-resistant tuberculosis has become an important public health problem at present[1]. In Indochina, especially for Myanmar and Thailand, the extensively drug-resistant Mycobacterium tuberculosis is an emerging problem[2]. The extensively drug-resistant M. tubercul…
Chawla GK, Garg K, Kaur K, Chopra V, Suri R
Background Drug resistant tuberculosis (DR-TB), particularly multidrug resistance (MDR-TB) and extensive drug resistance (XDR-TB) pose a serious threat to public health. This study aimed to identify drug resistance in pulmonary tuberculosis patients and to see their association w…
Yitagesu Habtu, Tesema Bereku, Girma Alemu, Ermias Abera
… among thirty high burden countries of multi-drug resistant tuberculosis (MDR-TB) in the regions of world health organization. Contextual evidence on the emergence of the disease is limited at a program level. </sec> <sec> <title>OBJECTIVE</title> The aim of the study is to explo…
Wahan SK, Bhargava G, Chawla V, Chawla PA
Multidrug-resistant tuberculosis continues to pose a health security risk and remains a public health emergency. Antimicrobial resistance result from treatment regimens that are both insufficient and incomplete leading to the emergence of multidrug-resistant tuberculosis, extensi…
Pedersen OS, Holmgaard FB, Mikkelsen MKD, Lange C, Sotgiu G, et al.
Introduction Historically, extensively drug-resistant tuberculosis has been notoriously difficult to treat with devasting outcomes. As we are coming to the end of an era where the 2006 extensively drug-resistant tuberculosis definitions and old treatment regimens are being replac…
Alfi Rahmatika, Muhammad Mufaiduddin, Innelya Innelya
Background: Tuberculosis (TB) is one of the major causes of death in the world with the number of cases reaching millions every year. TB is caused by Mycobacterium tuberculosis. The occurrence of mutations in M. tuberculosis that cause resistance to anti-tuberculosis drugs has be…
Pengwei Lou, Jiandong Yang, Yaoqin Lu, Yanggui Chen, Jiabo Xu
This study aims to predict the future incidence of tuberculosis in Urumqi using a dynamic model that incorporates pathogenic molecular characteristics. Sputum samples from tuberculosis patients in Urumqi were collected from 2017 to 2021. Following mycobacterium tuberculosis cultu…
Wilson M, Weston J, Mullen A, Knight T, Simpson G
… with global numbers, Australia has enjoyed relatively good tuberculosis control over the past 30 years, with an annual incidence of 5.7 per 100 000 population. Thanks to its unique geography and proximity to high-burden countries, such as Papua New Guinea (PNG), Far North Queens…
A. A. Zhurilo, A. I. Barbova
…lence of multidrug-resistant and extensively drug-resistant tuberculosis in the era of human immunodeficiency virus infection poses a serious threat to effective tuberculosis control. Drug resistance in M. tuberculosis occurs due to lowfrequency spontaneous chromosomal mutations.…
П. А. Хромова, С. Н. Жданова, Natalia Solovieva, V. V. Sinkov, Sergey M. Masharsky, et al.
…uded in the list of 30 countries with the highest burden of tuberculosis, including MDR tuberculosis. The most important part of this problem is the primary MDR/XDR TB in children. The aim: a comparative analysis of the phenotypic and genotypic profile of drug resistance to anti-…
…The article is devoted to the effectiveness of treatment of tuberculosis with MDR-TB and XDR-TB mycobacteria after the main course of chemotherapy. The treatment of tuberculosis with multiple and broad MD MBT is a com-plex and urgent task. Prescribing the latest generation of dru…
Ravindra Kushwaha, Rajeev Kumar, Ram Awadh Singh Kushwaha
Drug resistant tuberculosis (DR-TB) is a serious health issue worldwide and a number of mechanisms have been suggested which are involved in developing resistance in Mycobacterium tuberculosis to anti-tuberculosis drugs. In the Indian perspective, the pattern and prevalence of dr…
Dupont C, Chen Y, Xu Z, Roquet-Banères F, Blaise M, et al.
Mycobacterium tuberculosis , the causative agent of tuberculosis, remains a major human pathogen, and current treatment options to combat this disease are under threat because of the emergence of multidrug-resistant and extensively drug-resistant tuberculosis. High-throughput who…
Islam MI, Seo H, Kim S, Sadu VS, Lee KI, et al.
…nt (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis creates the urgency for new anti-tuberculosis drugs to improve the efficiency of current tuberculosis treatment. In the search for a new potential tuberculosis drug, we synthesized an isoindole based chemica…
Kim S, Seo H, Mahmud HA, Islam MI, Lee BE, et al.
Background Tuberculosis is a very serious infectious disease that threatens humanity, and the emergence of multidrug-resistant (MDR), extensively drug-resistant (XDR) strains resistant to drugs suggests that new drug development is urgent. In order to develop new tuberculosis dru…