Showing 176–200 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Araujo Z, de Waard JH, Camargo M, Lopez-Ramos JE, de Larrea CF, et al.
Diagnosis and treatment of active tuberculosis (ATB) as well as latent tuberculosis infection (LTBI) are required for effective tuberculosis (TB) control, especially in TB endemic area. The usefulness of conventional tests to distinguish between ATB and LTBI has remained challeng…
Alebouyeh S, Weinrick B, Achkar JM, García MJ, Prados-Rosales R
Tuberculosis (TB) is a global disease caused by Mycobacterium tuberculosis ( Mtb ) and is manifested as a continuum spectrum of infectious states. Both, the most common and clinically asymptomatic latent tuberculosis infection (LTBI), and the symptomatic disease, active tuberculo…
Bintang Yinke Magdalena Sinaga, Jelita Siregar, Delores Elisabeth Sormin, Rina Sundari, Yoseph Leonardo Samodra
…TIVE:** The WHO advises the detection of cases of pulmonary tuberculosis (TB) in household contacts (HHCs). This activity allows for testing family members of TB patients for latent tuberculosis infection (LTBI) and detecting factors associated with LTBI. The purpose of this stud…
Khayat M, Fan H, Vali Y
…this culminated in a microbiological diagnosis of pulmonary tuberculosis. The patient's daughter had been treated for tuberculosis two years earlier and unfortunately family screening for latent TB was not undertaken. This case appears to confirm the concerns that the CD4 + T-cel…
Liu J, Li Y, Liu T, Shi Y, Wang Y, et al.
Background Mycobacterium tuberculosis (Mtb) survives inside a human host for a long time in the form of latent tuberculosis infection (LTBI). Latent infection of tuberculosis has the opportunity of developing into active tuberculosis (ATB), which has greatly endangered human heal…
Xiao Xiao, Zhipeng Li, Jing Chen, Xin Shen
**BACKGROUND:** Students represent a key demographic for tuberculosis (TB) control in China. This study utilizes a dynamic Markov model to forecast the epidemiological trends of active tuberculosis (ATB) among students in Shanghai through 2035 and evaluate the effectiveness of di…
Thomaz Felipe Soares Arnizant, Filipe Andrade Bernardi, Tiago Lara Michelin Sanches, Nathalia Yukie Crepaldi, Thiago Nascimento do Prado, et al.
According to the World Health Organization (WHO), latent tuberculosis occurs through latent infection by Mycobacterium tuberculosis without evidence of active tuberculosis (TB) symptoms. As patients don’t develop the same symptoms as active TB, the treatment is abandoned before t…
Saadiq Garba, Heidi Fischer, Lei Qian, Zhuoxin Li, Katia Bruxvoort, et al.
…ract Background California has the largest number of active tuberculosis (TB) cases in the US; more than 2 million Californians are estimated to have latent tuberculosis infection (LTBI), and 87% of TB cases in 2021 were attributed to LTBI reactivation. This study in a large Cali…
Namuganga AR, Nsereko M, Bagaya BS, Mayanja-Kizza H, Chegou NN
…ckground There is a need for new tools for the diagnosis of tuberculosis (TB) amongst patients who present at primary health care centers with symptoms suggestive of TB. Objectives To assess the abilities of selected blood-based host biomarkers to discriminate between patients wh…
Yu Q, Yan J, Tian S, Weng W, Luo H, et al.
…n clinical metrics to discriminate between active pulmonary tuberculosis (APTB) and inactive pulmonary tuberculosis (IPTB). Patients and methods A total of 1096 patients with pulmonary tuberculosis (PTB) admitted to Wuhan Jinyintan Hospital between January 2017 and December 2019 …
VanValkenburg A, Kaipilyawar V, Sarkar S, Lakshminarayanan S, Cintron C, et al.
Background Most individuals exposed to Mycobacterium tuberculosis (Mtb) develop latent tuberculosis infection (LTBI) and remain at risk for progressing to active tuberculosis disease (TB). Malnutrition is an important risk factor driving progression from LTBI to TB. However, the …
Tesfaye F, Sturegård E, Walles J, Bekele B, Bobosha K, et al.
The immune control of tuberculosis (TB) infection could be influenced by pregnancy. To elucidate this, we longitudinally characterized Mycobacterium tuberculosis (Mtb)-specific and nonspecific immune responses in women during pregnancy and postpartum. HIV-uninfected women without…
Yue Wang, Rukeyamu Abudushalamu, Xiaoming Peng, Kadierya Nasier, Zihao Teng, et al.
…istic gut microbial alterations in Han patients with active tuberculosis (TB) and those with latent tuberculosis infection (LTBI). The findings are expected to support tailored strategies for the regional prevention and control of tuberculosis. **METHODS:** A total of 51 cases o…
Dewi Kartika Turbawaty, Adhi Kristianto Sugianli, Ahmad Rizal Ganiem, Ida Parwati
…AT-6), culture filtrate 10-kDa (CFP- 10), and Mycobacterium tuberculosis (Mtb) 64 (MPT-64) antigens are secreted by actively growing Mtb in active tuberculosis (TB) patients. Increased levels of ESAT-6, CFP-10, and MPT-64 at the site of infection facilitate the entry of antigens …
Nunes JES, Duque MA, de Freitas TF, Galina L, Timmers LFSM, et al.
…orld's population is estimated to have latent Mycobacterium tuberculosis infection, being at risk of developing active tuberculosis (TB) during their lifetime. Given the inefficacy of prophylactic measures and the increase of drug-resistant M. tuberculosis strains, there is a cle…
Luo Y, Xue Y, Liu W, Song H, Huang Y, et al.
Background The discrimination between active tuberculosis (ATB) and latent tuberculosis infection (LTBI) remains challenging. The present study aims to investigate the value of diagnostic models established by machine learning based on multiple laboratory data for distinguishing …
Stringari LL, Covre LP, da Silva FDC, de Oliveira VL, Campana MC, et al.
…y T cells (Tregs) play a critical role during Mycobacterium tuberculosis (Mtb) infection, modulating host responses while neutralizing excessive inflammation. However, their impact on regulating host protective immunity is not completely understood. Here, we demonstrate that Treg…
Xi X, Wang B, Zhang R, Ling C
…xosome tRFs/tiRNAs and to explore their diagnostic value in tuberculosis (TB) activity. Methods The serum exosome tRF/tiRNA profile was analysed using high-throughput sequencing technology in 5 active tuberculosis (ATB) patients, 5 latent tuberculosis infection (LTBI) patients an…
Mohau S. Makatsa, F. Millicent A. Omondi, Rubina Bunjun, Robert J. Wilkinson, Catherine Riou, et al.
ABSTRACT The development of a highly effective tuberculosis (TB) vaccine is likely dependent on our understanding of what constitutes a protective immune response to TB. Accumulating evidence suggests that CD4+ T cells producing IL-22, a distinct subset termed ‘Th22’ cells, may c…
Luo Y, Xue Y, Song H, Tang G, Liu W, et al.
Background Discriminating active tuberculosis (ATB) from latent tuberculosis infection (LTBI) remains challenging. The present study aims to evaluate the performance of diagnostic models established using machine learning based on routine laboratory indicators in differentiating …
Patrick Lungu, Duncan Chanda, Gershom Chongwe, Shabir Lakhi
Background: Screening of contacts of tuberculosis (TB) patients is not routinely done in resourcelimited countries like Zambia despite the World Health Organization (WHO) recommendations, leading to missed opportunities for prevention, early diagnosis and high mortality.Objective…
Anjum Hameed Dr. Manal Tanveer
…on of fund receiving forums and TB research implementation. Tuberculosis (TB) causes millions of deaths every year across the globe and it is ranked among most alarming infectious diseases. This research overviews general treatment guidelines, diagnosis and pathogenesis of TB. Be…
Ebru Yalçın, Nagehan Emiralioğlu, Gökçen Dilşa Tuğcu, Sanem Eryılmaz, Mina Hızal, et al.
… there is strong evidence of its role in the development of tuberculosis(Tb) disease. Our aim is to determine the levels of vitamin D, cathelicidin B(LL-37) in patients with Tb disease, latent Tb infection(LTBI) and healthy children. Our second aim of this study is to determine t…
Shi SD, Hsueh PR, Yang PC, Chou CC
As more than two billion people possibly have a latent tuberculosis (LTB) infection, early LTB diagnosis is crucial for the efficient control and elimination of tuberculosis (TB). The aim of this study is to detect the serum antibody responses to dormancy-related DosR regulon ant…
Wang X, Jiang K, Xing W, Xin Q, Hu Q, et al.
Background Distinguishing between active tuberculosis disease (TBD) and latent tuberculosis infection (TBI) is crucial for TB control but remains challenging. Methods Single-cell RNA sequencing was conducted on purified Mycobacterium tuberculosis (MTB)-specific CD154 + CD4 + T ce…