Showing 176–200 of 200 documents
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Sanami S, Rafieian-Kopaei M, Dehkordi KA, Pazoki-Toroudi H, Azadegan-Dehkordi F, et al.
…ed. There are currently commercially available prophylactic vaccines that have been shown to protect vaccinated individuals against HPV infections, however, these vaccines have no therapeutic effects for those who are previously infected with the virus. The current study's aim wa…
Cholewik M, Stępień M, Bieńkowski C, Pokorska-Śpiewak M
Background: Russia's aggression against Ukraine in early 2022 resulted in a large migration of refugees to many countries, including Poland. Vaccination coverage for some infectious diseases in Ukraine is lower than in Poland; consequently, the incidence of infectious diseases-in…
Meskell P, Biesty LM, Dowling M, Roche K, Meehan E, et al.
…ential risks and benefits associated with rapidly developed vaccines. Objectives To explore the factors that influence a person's decision to participate in a vaccine trial in the context of a pandemic or epidemic. Search methods We used standard, extensive Cochrane search method…
Tameris M, Mearns H, Penn-Nicholson A, Gregg Y, Bilek N, et al.
…nd Infants are a key target population for new tuberculosis vaccines. We assessed the safety and immunogenicity of the live-attenuated Mycobacterium tuberculosis vaccine candidate MTBVAC in adults and infants in a region where transmission of tuberculosis is very high. Methods We…
Joann Diray‐Arce, Asimenia Angelidou, Kristoffer Jarlov Jensen, Maria Giulia Conti, Rachel S. Kelly, et al.
Summary Vaccines have generally been developed with limited insight into their molecular impact. While systems vaccinology, including metabolomics, enables new characterization of vaccine mechanisms of action, these tools have yet to be applied to infants at high risk of infectio…
Yang Liu, Yuanyuan Zhang, Ning Yao, Zhiyong Zhang, Qing Wang, et al.
…ment information as well as the vaccination records of live vaccines. Two stool samples were collected for virus detection and the vaccine-derived poliovirus was analyzed. A total of 26 primary immunodeficiency patients were enrolled among 3312 monitored cases, including 5 cases …
Folegatti PM, Jenkin D, Morris S, Gilbert S, Kim D, et al.
…2012. The Brighton Collaboration Benefit-Risk Assessment of VAccines by TechnolOgy (BRAVATO) was formed to evaluate the safety and other key features of new platform technology vaccines. This manuscript reviews key features of the ChAdOx1-vectored vaccines. The simian adenovirus …
Prabowo SA, Painter H, Zelmer A, Smith SG, Seifert K, et al.
Tuberculosis (TB) is a major global health problem and there is a dire need for an improved treatment. A strategy to combine vaccination with drug treatment, termed therapeutic vaccination, is expected to provide benefit in shortening treatment duration and augmenting treatment s…
Teljeur C, Moran PS, Harrington P, Butler K, Corcoran B, et al.
Background In Western Europe, currently only Ireland and Portugal continue to provide universal neonatal bacillus Calmette-Guérin (BCG) vaccination programs, despite not being considered as high tuberculosis (TB) incidence countries. Other European countries only vaccinate infant…
Hoft SG, Kauffman KD, Sakai S, Lindestam Arlehamn CS, Sette A, et al.
…nding T cells may enhance the airway immunogenicity of oral vaccines.
Zhuang L, Ye Z, Li L, Yang L, Gong W
…cy, particularly in adults. Efforts to develop effective TB vaccines have been ongoing for nearly a century. In this review, we have examined the current obstacles in TB vaccine research and emphasized the significance of understanding the interaction mechanism between MTB and ho…
Socha A, Klein J
Background Migrant populations in the European Union (EU) suffer a disproportionate burden of infectious diseases and may be particularly vulnerable due to poor conditions in countries of origin or throughout transit to the host country. Given the rising level of migration into E…
Ostermann J, Vasudevan L, Baumgartner JN, Ngadaya E, Mfinanga SG
Background Vaccination is a cost-effective strategy for reducing morbidity and mortality among children under 5 years old. To be fully protected from diseases such as tuberculosis, diphtheria, pertussis, and polio, children must receive all recommended vaccinations in a timely ma…
Bhattacharyya A, Shahabuddin SM
…asles vaccine for children and rubella and adult diphtheria vaccines for pregnant women. We conducted this rapid review on adult immunization relevant for India, as recent COVID-19 experience revealed how newly emergent or re-emergent pathogens could have their onslaughts on the …
Rupali Limaye, Jessica Schue, Berhaun Fesshaye, Prachi Singh, Emily Miller, et al.
… to maternal and neonatal health. For TB and GBS, there are vaccines in various stages of clinical trial development, and malaria and RSV vaccines are available. This study aimed to examine pregnant women's attitudes toward TB, malaria, GBS, and RSV vaccines in Brazil, Ghana, Ken…
И В Фельдблюм, M. Yu. Devyatkov, M. Kh. Alyeva
Relevance Hepatitis B and tuberculosis are a serious global health problem. Babies under one are at high risk of a severe form of these diseases and mortality. Immunization of newborns plays a key role both in the individual prevention of hepatitis B and tuberculosis and in reduc…
И В Фельдблюм, M. Yu. Devyatkov, M. Kh. Alyeva
Relevance Hepatitis B and tuberculosis are a serious global health problem. Babies under one are at high risk of a severe form of these diseases and mortality. Immunization of newborns plays a key role both in the individual prevention of hepatitis B and tuberculosis and in reduc…
Thakur A, Ingvarsson PT, Schmidt ST, Rose F, Andersen P, et al.
Liquid vaccine dosage forms have limited stability and require refrigeration during their manufacture, distribution and storage. In contrast, solid vaccine dosage forms, produced by for example spray drying, offer improved storage stability and reduced dependence on cold-chain fa…
Tingting Li, K. J. Zhu, Yujie Kuang, Hongbo Qu, Zhang Qi, et al.
Abstract Background: Tuberculin skin test (TST) has been the most commonly used test for diagnosis of tuberculosis (TB) infection in China for many years, because of well-established algorithms for test interpretation and a good cost-effectiveness. To our knowledge , there is no …
Tong Yu, ChenChao Zhang, Jun-Hong Xing, Tong Zhang, Zhiqiang Xu, et al.
…, the urgent development of innovative and efficacious mRNA vaccines is imperative. In our study, we synthesized six unique mRNA vaccine formulations: the Receptor Binding Domain (RBD) monomer vaccine, RBD dimer (2RBD) vaccine, RBD-Ferritin (RBD-Fe) vaccine, ubiquitin-modified wi…
Ramón A. Juste, Mariví Geijó, Natalia Elguezábal, Iker A. Sevilla, Marta Alonso‐Hearn, et al.
…ontrasting the literature, no deleterious effects of killed vaccines on females were observed. Mortality reduction would offset vaccination costs and could improve livestock systems efficiency and potentially reduce antibiotic use. Clinical trial registered with Spanish Agency fo…
Weerasuriya CK, Harris RC, McQuaid CF, Bozzani F, Ruan Y, et al.
…rough the development pipeline, how novel tuberculosis (TB) vaccines might affect rifampicin-resistant and multidrug-resistant tuberculosis (RR/MDR-TB) is unknown. We investigated the epidemiologic impact, cost-effectiveness, and budget impact of hypothetical novel prophylactic p…
Mustafa Aslan, İlke Özer Aslan, Öner Özdemır
Dear Editor, COVID-19 is a new type of respiratory infection and might lead to serious pneumonia causing acute respiratory distress syndrome (ARDS). Most people infected with SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) manifest as having asymptomatic or mild to m…
Brett K, Severn M
… general use, and it is one of the most widely administered vaccines. Nevertheless, there are still some questions with regards to the effectiveness of the BCG vaccine, particularly, the duration of the effect, and the ability to protect against pulmonary TB in adults. A global r…
Williams GA, Allen D, Brewer J, Salguero FJ, Houghton S, et al.
Bovine tuberculosis (bTB), caused by Mycobacterium bovis infection, is a zoonotic disease in cattle that represents a significant ongoing challenge to cattle farming productivity and the livelihoods of livestock farmers in the UK. Vaccination of cattle with BCG could directly tar…