Showing 176–200 of 200 documents
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Jia Q, Masleša-Galić S, Nava S, Horwitz MA
Mycobacterium tuberculosis infects approximately one-third of the world's population, causing active tuberculosis (TB) in ~10 million people and death in ~1.5 million people annually. A potent vaccine is needed to boost the level of immunity conferred by the current Mycobacterium…
Shayan Shah, Michael Eisenhut
<b>Background:</b> Active tuberculosis has been associated with false negative interferon gamma release assay (IGRA) results. This may relate to a suppression of the interferon gamma response associated with a more extensive Mycobacterium (M.) tuberculosis infection. <b>Objective…
E. E. Lesnik, S. Ginda
…ers of cellular, humoral immunity and natural resistance in tuberculosis patients with primary and acquired multiple drug resistance; to study the correlation of these parameters with clinical and radiological manifestations. Subjects and Methods. A prospective study was conducte…
Lennard Meiwes, Irina Kontsevaya, Dumitru Chesov, Stela Kulciţkaia, Viola Dreyer, et al.
…ce mask sampling (FMS) confirmed detection of Mycobacterium tuberculosis DNA from exhaled breath in adults with tuberculosis. To date, no study has evaluated the use of FMS to detect pulmonary tuberculosis in children. We developed a method for FMS of M. tuberculosis-specific DNA…
Bi D, Liang C, Huang X, Pan H, Qin Y, et al.
…ility of commercially available antibodies of Mycobacterium tuberculosis in the diagnostic assessment of suspected tuberculosis in high-burden countries. Methods We conducted a retrospective, descriptive, cohort study among participants aged ≥ 18 years with suspected tuberculosis…
Saha A, Escuduero J, Layouni T, Richardson B, Hou S, et al.
…ound Pregnancy is a risk factor for progression from latent tuberculosis infection to symptomatic tuberculosis. However, how pregnancy influences T-cell responses to Mycobacterium tuberculosis is unknown. Methods We measured M. tuberculosis-specific cytokines, T-cell memory marke…
О.С. Шевченко, L.D. Todoriko, R.S. Shevchenko, S.L. Matvyeyeva, І.А. Овчаренко, et al.
…s well as the treatment regimens in patients with pulmonary tuberculosis. Materials and methods. This study included 100 patients with pulmonary tuberculosis, divided into two groups: Group 1 (n = 52) with drug-susceptible tuberculosis and Group 2 (n = 48) with drug-resistant tub…
Ihor Dmytrovych Duzhyi, Г.П. Олещенко, Л.А. Бондаренко
The incidence of tuberculosis in our country, according to statistics, seems to be declining. However, it should be remembered that the figures of the Crimean Autonomous Republic and the temporarily occupied territories of Donetsk and Luhansk oblasts are excluded from the digital…
Pelzer PT, Stuck L, Martinez L, Richards AS, Acuña-Villaorduña C, et al.
Background Tuberculosis vaccine trials using disease as the primary endpoint are large, time consuming, and expensive. An earlier immunological measure of the protection against disease would accelerate tuberculosis vaccine development. We aimed to assess whether the effectivenes…
Meiwes L, Kontsevaya I, Chesov D, Kulciţkaia S, Dreyer V, et al.
…ce mask sampling (FMS) confirmed detection of Mycobacterium tuberculosis DNA from exhaled breath in adults with tuberculosis. To date, no study has evaluated the use of FMS to detect pulmonary tuberculosis in children. We developed a method for FMS of M. tuberculosis-specific DNA…
Barham MS, Whatney WE, Khayumbi J, Ongalo J, Sasser LE, et al.
…ficant risk factor for reactivation of latent Mycobacterium tuberculosis infection (LTBI) and progression to active tuberculosis disease, yet the mechanisms whereby HIV impairs T cell immunity to M. tuberculosis have not been fully defined. Evaluation of M. tuberculosis -specific…
Khushpreet Kaur, Sumedha Sharma, Sudhanshu Abhishek Sinha, Prabhdeep Kaur, Uttam Chand Saini, et al.
Abstract Bone tuberculosis is widely characterized by irreversible bone destruction caused by Mycobacterium tuberculosis . Mycobacterium has the ability to adapt to various environmental stresses by altering its transcriptome in order to establish infection in the host. Thus, it …
Rebecca Berhanu, Karen R. Jacobson
EditorialsOctober 2021Tuberculosis Preventive Therapy for People With HIV Infection in High Tuberculosis Burden Settings: How Much Is Enough?Rebecca H. Berhanu, MD and Karen R. Jacobson, MD, MPHRebecca H. Berhanu, MDBoston University School of Public Health, Boston, Massachusetts…
Tangkat Friday Hosle
Tuberculosis is a communicable disease caused by Mycobacterium tuberculosis, considered a major risk to global health security. This study determined the prevalence, treatment outcomes, and factors associated with tuberculosis among 737 presumptive tuberculosis patients in Federa…
G.I.A. Okoroiwu, Gloria I. Onokpise
Introduction: The occurrence of multi-drug resistance tuberculosis among tuberculosis patients has raised global public health concern, especially in Nigeria. The increase in the number of cases of resistance tuberculosis despite the effort and need to curb the menace in Nigeria …
Puck T. Pelzer, Logan Stuck, Leonardo Martínez, Alexandra S Richards, Carlos Acuña-Villaorduña, et al.
BACKGROUND: Tuberculosis vaccine trials using disease as the primary endpoint are large, time consuming, and expensive. An earlier immunological measure of the protection against disease would accelerate tuberculosis vaccine development. We aimed to assess whether the effectivene…
Bisson GP, Bastos M, Campbell JR, Bang D, Brust JC, et al.
…ociated with increased mortality during multidrug-resistant tuberculosis treatment, but the extent to which the use of antiretroviral therapy (ART) and anti-tuberculosis medications modify this risk are unclear. Our objective was to evaluate how use of these treatments altered mo…
Seid G, Alemu A, Dagne B, Sinshaw W, Gumi B
Background The Mycobacterium tuberculosis complex causes tuberculosis, a severe public health problem. Close contacts of someone who has active pulmonary tuberculosis were at a greater risk of contracting the disease. Despite the large number of primary research available in Sub-…
Honjo K, Komiya K, Kan T, Uchida S, Goto A, et al.
…e advanced age is a main prognostic factor in patients with tuberculosis, the factors that specifically affect tuberculosis-related death are unclear because elderly people are at a risk for other age-related lethal diseases. We aimed to assess the impact of performance status on…
Leni Wahyuni, Agrijanti Agrijanti, Lalu Srigede
Tuberculosis is a contagious infectious disease caused by the bacteria Mycobacterium tuberculosis or often called Acid-Fast Bacteria (AFC). Tuberculosis positive patients must undergo treatment by administering category 1 Anti-Tuberculosis Drugs (ATD) for approximately 6-8 months…
И.А. Ратникова, А.К. САДАНОВ, Elmira Namaz, B.B. BAIMAKHANOVA, Vyacheslav G. Melnikov, et al.
Tuberculosis remains one of the most common infectious diseases worldwide. The epidemiology of this disease shows that tuberculosis caused by mycobacteria, especially Mycobacterium tuberculosis, is still widespread, especially in developing countries. The study and development of…
Jong Hoon Hyun, Myeongjee Lee, Inkyung Jung, Eun‐Hwa Kim, Seung Min Hahn, et al.
…cipients are immunocompromised and vulnerable to developing tuberculosis; however, active tuberculosis incidence is rapidly declining in South Korea. To evaluate the risk of developing active tuberculosis after transplantation, risk factors for tuberculosis and standardized incid…
Leyla Larsson, Ioana Diana Olaru, Anna-Lisa Behnke, Edson T Marambire, Martha Chipinduro, et al.
**BACKGROUND:** Tuberculosis elimination is constrained by symptom-based and sputum-dependent diagnostic strategies, which miss asymptomatic disease and are difficult to deploy in community settings. Household contacts of people with tuberculosis are a priority population for scr…
Ayenew Berhan, Bekele Sharew, Andargachew Almaw, Shewaneh Damtie, Biruk Legese, et al.
**BACKGROUND AND AIMS:** Tuberculosis is a major infectious disease that affects hematological profiles. However, limited data assess changes in hematological profiles among patients with pulmonary and multidrug-resistant tuberculosis. Therefore, this study aimed to compare the h…
Harirzadeh S, Kazemi MJ, Babakhani S
Introduction: Mycobacterium tuberculosis is the cause of pulmonary and extra-pulmonary tuberculosis. Latent tuberculosis is asymptomatic and the results of mycobacterial culture in this case are negative. The purpose of this study was to determine the prevalence of M. tuberculosi…