Showing 151–175 of 200 documents
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Ngula Monde, Mildred Zulu, Mathias Tembo, Ray Handema, Musso Munyeme, et al.
…tries in sub-Saharan Africa is affected with drug resistant tuberculosis. However, the drug resistant tuberculosis situation over the years has not been described in various regions of the country. Consequently, this study aims to determine the drug resistant tuberculosis burden …
Chen Yang, Guangchuan Dai, Yicheng Guo, Tianzhen Wang, Weiwei Gao, et al.
**BACKGROUND:** Drug-resistant tuberculosis has emerged as a major public health issue that requires immediate attention. NTS is an innovative method that allows for the direct detection of clinical samples without the need for culture. It could provide more accurate, reliable, a…
Amin A, Vartanian A, Yegiazaryan A, Al-Kassir AL, Venketaraman V
Tuberculosis disease is caused by the bacterium Mycobacterium tuberculosis . It is estimated that 10 million people have developed tuberculosis disease globally, leading to 1.4 million deaths in 2019. Treatment of tuberculosis has been especially challenging due to the rise of mu…
Natarajan A, Beena PM, Devnikar AV, Mali S
Tuberculosis (TB), which is caused by bacteria of the Mycobacterium tuberculosis complex, is one of the oldest diseases known to affect humans and a major cause of death worldwide. Tuberculosis continues to be a huge peril disease against the human population and according to WHO…
О.С. Шевченко, Svitlana Matveyeva, Anna Stepanenko, Olexandra Choporova, Olha Pohorielova
PECULIARITIES OF DRUG-RESISTANT TUBERCULOSIS IN UKRAINE AND KHARKIV REGION 
 Shevchenko O., Matveyeva S., Stepanenko A., Choporova O., Pohorielova O.
 Background. Multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis remain severe epidemic problem…
Cristina Daniela Marineci, Cristina Elena Zbârcea, Simona Negreș
Tuberculosis is a chronic infection, most often affecting the lungs, which usually manifests after a latency period from primary infection with Mycobacterium tuberculosis. Symptoms are generally nonspecific, with fever, cough, weight loss and malaise. The diagnosis is based on mi…
Mizukoshi F, Kobayashi N, Kirikae F, Ohta K, Tsuyuguchi K, et al.
…stant (isoniazid and/or rifampicin-resistant) Mycobacterium tuberculosis were obtained from 254 patients diagnosed with drug-resistant tuberculosis in Japan from April 2015 to March 2017 in National Hospital Organization hospitals. The 254 patients were approximately 32% of all 7…
Getachew Kahsu Abay, Bahlibi Hailay
Abstract Background Tuberculosis (TB) is an infectious disease usually caused by Mycobacterium tuberculosis (MTB) bacteria. The emergence of Mono or multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis (XDR-TB), poses a considerable challenge to Mycobacter…
Zürcher K, Reichmuth ML, Ballif M, Loiseau C, Borrell S, et al.
Background Drug resistance threatens global tuberculosis control. We aimed to examine mortality in patients with tuberculosis from high-burden countries, according to concordance or discordance of results from drug susceptibility testing done locally and whole-genome sequencing (…
Nimmo C, Millard J, van Dorp L, Brien K, Moodley S, et al.
…mine are important drugs in the treatment of drug-resistant tuberculosis and are commonly used across southern Africa, although drug susceptibility testing is not routinely performed. In this study, we did a genotypic and phenotypic analysis of drug-resistant Mycobacterium tuberc…
Parissa Farnia, Ali Akbar Velayati
…mes with a new definition of pre-extensively drug-resistant tuberculosis (XDR-TB) and XDR-TB. New definitions for pre-XDR and XDR-TB helped to define more precisely groups of TB patients who require complex treatment regimens.[1] The definition of pre-XDR-TB applied to TB caused …
Christoph Lange, Yousra Kherabi, Lorenzo Guglielmetti, Raquel Duarte, Gunar Günther
…sistance testing for BPaLM regimen for rifampicin-resistant tuberculosis in Europe”, published in this journal ( 1 Günther G, Guglielmetti L, Kherabi Y, Duarte R, Lange C; Tuberculosis Network European Trials group. Availability of drugs and resistance testing for bedaquiline, pr…
О. М. Raznatovska, V.I. Petrenko, О.S. Shalmin, R.M. Yasinskyi, A.V. Fedorec, et al.
We present our own observation of the multifocal tuberculosis with pre-extensive drug resistance (pre-XDR-TB) development in a patient who was treated in the pulmonary tuberculosis department No. 2 of the Zaporizhzhia’ regional phthisio-pulmonology clinical treatment and diagnos…
Afsaneh Kaffash, Saeideh Sadat Shobeiri, Elham Pouraslan, Asghar Kazemzadeh, Fatemeh Doost Mohammadi, et al.
…** This ecological study examines epidemiological trends in tuberculosis, multidrug-resistant TB, extensively drug-resistant TB, and latent TB infection across Iran and its provinces from 1990 to 2021, and explores their association with the Human Development Index. **METHODS:**…
Shuaibu Abdullahi Hudu
Tuberculosis is still the most prevalent infectious cause of mortality, and it has a significant medical, societal, and economic impact MDR-TB is a type of tuberculosis (TB) infection produced by bacteria resistant to at least two of the most important first-line anti-TB treatmen…
Sheikh BA, Bhat BA, Mehraj U, Mir W, Hamadani S, et al.
Tuberculosis (TB) is a prominent infective disease and a major reason of mortality/ morbidity globally. Mycobacterium tuberculosis causes a long-lasting latent infection in a significant proportion of human population. The increasing burden of tuberculosis is mainly caused due to…
Jain P, Garing S, Verma D, Saranathan R, Clute-Reinig N, et al.
Phenotypic testing for drug susceptibility of Mycobacterium tuberculosis is critical to basic research and managing the evolving problem of antimicrobial resistance in tuberculosis management, but it remains a specialized technique to which access is severely limited. Here, we re…
O'Donnell MR, Larsen MH, Brown TS, Jain P, Munsamy V, et al.
A critical gap in tuberculosis (TB) treatment is detection of emergent drug resistance. We hypothesized that advanced phenotyping with whole-genome sequencing (WGS) will detect low-frequency Mycobacterium tuberculosis drug resistance. We assessed a reporter mycobacteriophage (Φ 2…
T. I. Cookey, Sofiat Adewuyi-Oseni, I. O. Okonko, K. C. Anugweje
Aim: Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis, is a strictly aerobic bacterium that grows fastidiously and slow, which is among the top 10 causes of death globally and the leading cause from a single infectious agent (above HIV/AIDS). Among the deadly…
Zürcher K, Ballif M, Fenner L, Borrell S, Keller PM, et al.
…nd Drug resistance is a challenge for the global control of tuberculosis. We examined mortality in patients with tuberculosis from high-burden countries, according to concordance or discordance of results from drug susceptibility testing done locally and in a reference laboratory…
Deshpande D, Srivastava S, Bendet P, Martin KR, Cirrincione KN, et al.
…monstrated that benzylpenicillin did not kill Mycobacterium tuberculosis In this study, we found that >64 mg/liter of static benzylpenicillin concentrations killed 1.16 to 1.43 log 10 CFU/ml below starting inoculum of extracellular and intracellular M. tuberculosis over 7 days. W…
Inna Friesen, Timo Ulrichs, L. A. Hryshchuk, H. S. Saturska
… to compare the epidemiological situation of chemoresistant tuberculosis in Germany and Ukraine, in addition analyzing the nature and features of chemoresistant tuberculosis in 192 patients treated at the Ternopil Regional TB Dispensary Ukraine during 2017—2018.
 Materials a…
Muhammad Akram, Abid Mahmood, Mohammed Khudhair Hasan, Isaac John Umaru, Hind A. Abdulghafoor, et al.
…s. Mainly affecting the lungs (pulmonary TB), Mycobacterium tuberculosis is a slow-growing, acid-fast bacillus that causes tuberculosis. However, it may also affect other organs, such as the lymph nodes, bones, central nervous system, and genitourinary tract. Due to a number of v…
О. А. Пасечник, В. Л. Стасенко
…modeling the further development of the epidemic process of tuberculosis in several regions of the world, including the Russian Federation, indicate an unfavorable prognosis in the spread of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis. Purpose of…
Анна Старшинова, E. N. Belyaeva, Igor Kudryavtsev, Artem Rubinstein, Leonid P. Churilov, et al.
…Health Organization (WHO), nearly 10.6 million new cases of tuberculosis were detected in 2022, indicating an increase of 3.5 % from the reported 10.3 million in 2021. After the COVID-19 pandemic, the incidence of tuberculosis increased by 3.9 % from 2020 to 2022. According to th…