Showing 151–175 of 200 documents
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M. A. Vladimirskiy, M. B. Lapenkova, A. A. Elov, В. А. Аксенова, М. А. Плеханова, et al.
…led in the study, of them 8 children suffered from pulmonary tuberculosis (TB Group) and 91 had LTBI (LTBI Group). Detection of subclinical signs of tuberculosis infection activity in LTBI Group included testing the concentration of antigen-specific induction of IFN-γ at the level …
Jeffrey M. Singh, Lamiya Balushi, Nada Mahrazi, Esklid Peterson, Olivier Koole, et al.
…ackground: Oman is a high-income, low prevalent country for tuberculosis disease. Although the rates have remained static over the last decade, the country is aiming for Tuberculosis (TB) elimination. Household contacts of pulmonary TB (PTB) patients form a high-risk group of sus…
Azadeh Jafrasteh, Abdollah Karimi, Seyedeh Mahsan Hoseini‐Alfatemi, Leila Azimi, Payam Tabarsi, et al.
…are the most important diagnostic approach to Mycobacterium tuberculosis infection diagnosis. However, they cannot discriminate between latent tuberculosis infection (LTBI) and active tuberculosis (TB). Some recent studies suggested that interleukin-2 (IL-2) response to M. tuberc…
Rosana Agus, Sjafaraenan, Yulianti Samara, Muhammad Nasrum Massi
The main challenge in the management of Tuberculosis (TB) is diagnosing quickly and accurately, especially Latent Tuberculosis Infection (LTBI). LTBI detection was carried out using the Tuberculin Skin Test (TST) and Interferon Gamma Release Assay (IGRA). In TB endemic areas, the…
Fengjuan Wang, Lei Zhou, Xiaoyan Hao, Jiayun Liu
…pathogens and is a contributing factor to the occurrence of tuberculosis infection. The primary objective of this investigation was to examine the risk factors for the progression from latent tuberculosis infection (LTBI) to active tuberculosis (ATB) in patients with rheumatic di…
Hanthamrongwit J, Aruvornlop P, Saelee C, Wanta N, Poneksawat P, et al.
Multi-stage tuberculosis (TB) vaccines composed of active- and dormancy-associated antigens are promising to trigger the immune protection against all TB stages. However, scientists are still in quest of the suitable vaccine candidates. In this study, we identified the potential …
Qiu B, Liu Q, Li Z, Song H, Xu D, et al.
…ents, a sensitive and specific method to distinguish active tuberculosis from latent tuberculosis infection (LTBI) would allow for early diagnosis and limit the spread of the pathogen. The analysis of multiple cytokine profiles provides the possibility to differentiate the two di…
Sun T, Wu B, Wang J, Yuan T, Huang H, et al.
…is important to distinguish those with active Mycobacterium tuberculosis infection (ATB) from latent tuberculosis infection (LTBI) for monitoring and treating the disease. Monocytes play an important role and may undergo morphological changes against active TB infection. The aim …
Rebeiro PF, Cohen MJ, Ewing HM, Figueiredo MC, Peetluk LS, et al.
Background Tuberculosis (TB) elimination requires treatment of millions of persons with latent M. tuberculosis infection (LTBI). LTBI treatment acceptance depends on population-wide TB knowledge and low stigma, but limited data are available on the relationship between stigma and…
Sanghmitra Singh, Geetu Singh, Himalaya Singh, Gajendra Vikram Singh
Introduction: Tuberculosis (TB) remains a significant global health challenge, with India bearing the highest burden. Tuberculosis Preventive Therapy (TPT) is a critical strategy to prevent latent TB infection (LTBI) from progressing to active disease, particularly among househol…
Sofia Kostoudi, Robert Hammond
ABSTRACT Background Tuberculosis (TB) is the second leading infectious killer after COVID-19 and the 13 th leading cause of death worldwide. Latent tuberculosis (LTBI) has become a major pool of potential active tuberculosis cases and is propelling the TB global health burden fur…
Meier NR, Battegay M, Ottenhoff THM, Furrer H, Nemeth J, et al.
…In individuals living with HIV infection the development of tuberculosis (TB) is associated with rapid progression from asymptomatic TB infection to active TB disease. Sputum-based diagnostic tests for TB have low sensitivity in minimal and subclinical TB precluding early diagnos…
Revadi G, Johann Aibantyllilang Blah, Manoj Verma, Arun M Kokane
**INTRODUCTION:** Latent Tuberculosis infection (LTBI) care cascade involves identification of high-risk individuals, testing, identification of LTBI, initiation of Tuberculosis Preventive therapy (TPT) and documentation of outcomes. There is a dearth of such evidence in Indian s…
Seers T, Quah H, Ludwig D, Noursadeghi M, Brown M, et al.
…ing for an aetiology. Despite previous treatment for latent tuberculosis, he developed changes typical for miliary tuberculosis and was started on antituberculosis therapy; whole genome sequencing later demonstrated isoniazid monoresistance. This case demonstrates both the import…
Collin R. Diedrich, Tara Rutledge, Pauline Maiello, Tonilynn Baranowski, Alexander G. White, et al.
…nfection is the most common risk factor for severe forms of tuberculosis (TB), regardless of CD4 T cell count. Using a well-characterized cynomolgus macaque model of human TB, we compared radiographic, immunologic and microbiologic characteristics of early (subclinical) reactivat…
Aravindhan V, Yuvaraj S
Tuberculosis patients with diabetes, have higher sputum bacillary load, delayed sputum conversion, higher rates of drug resistance, higher lung cavitary involvement and extra-pulmonary TB infection, which is called as "Diabetes-Tuberculosis Nexus". However, recently we have shown…
Liang Y, Li X, Yang Y, Xiao L, Liang Y, et al.
…round About a quarter of the world's population with latent tuberculosis infection (LTBI) are the main source of active tuberculosis. Bacillus Calmette Guerin (BCG) cannot effectively control LTBI individuals from developing diseases. Latency-related antigens can induce T lymphoc…
Wang S, Wu J, Chen J, Gao Y, Zhang S, et al.
…n tests offer several advantages for the rapid diagnosis of tuberculosis (TB). The Mycobacterium tuberculosis-specific antibody responses associated with different stages of TB infection remain to be investigated. Methods The Pathozyme-Myco IgG (Myco G), Pathozyme TB Complex Plus…
Winglee K, Hill AN, Belknap R, Stout JE, Ayers TL
…ERON Gold In-Tube (QFT), are important diagnostic tools for tuberculosis infection, but little work has been done to study the performance of these tests in populations prioritized for tuberculosis testing in the United States, especially those other than health care personnel. M…
Kase AM, Libertin CR, Roy A
…anti-TNF pharmaceuticals increases the risk of reactivating tuberculosis making screening for latent tuberculosis infection (LTBI) a requirement prior to initiating therapy. Case A middle-aged male from China with a past medical history of LTBI and Crohn's disease, previously on …
He J, Fan Y, Shen D, Yu M, Shi L, et al.
Background Tuberculosis (TB) is an infectious disease and its mortality rate ranks first. Latent tuberculosis infection (LTBI) means that a patient is infected with Mycobacterium tuberculosis, but has no relative clinical symptoms. It has been estimated that approximately 10% of …
Stockbridge EL, Miller TL, Carlson EK, Ho C
…Targeted identification and treatment of people with latent tuberculosis infection (LTBI) are key components of the US tuberculosis elimination strategy. Because of recent policy changes, some LTBI treatment may shift from public health departments to the private sector. Objectiv…
Charutha Retnakumar, Komala Ezhumalai, Ruben Raj, Prakash Babu Narasimhan, Subitha Lakshminarayanan, et al.
Introduction: Tuberculosis control remains an ongoing challenge for low and middle-income countries with lack of understanding of the factors determining transmission of infection. This study aimed to investigate the impact of alcohol use among pulmonary tuberculosis patients on …
Herrera M, Keynan Y, López L, Marín D, Arroyave L, et al.
…f liberty (PDL) are at high risk of acquiring Mycobacterium tuberculosis infection (latent tuberculosis infection [LTBI]) and progressing to active tuberculosis (TB). We sought to determine the incidence rates and factors associated with LTBI and active TB in Colombian prisons. U…
Gaensbauer J, Aiona K, Haas M, Reves R, Young J, et al.
…ve the highest age-specific rate of progression from latent tuberculosis infection (LTBI) to active disease. Therefore, regimens for treatment of pediatric LTBI must be not only efficacious but practical enough to overcome the unique childhood barriers to regimen adherence. Since…