Showing 126–150 of 200 documents
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Pavithra GB, R. Prassanna Adithiyan, B Charumathi, Timsi Jain
Background: Non- adherence is one of the major risk factors for the emergence of MDR and XDR TB. It is also one of the key factors responsible for treatment failure, disease relapse, prolonged infection and death. This study was conducted to explore the various factors contributi…
World Health Organization
Keikha M, Majidzadeh M
We found that the frequency of Beijing genotype among XDR-TB strains was high. The data in this study would help guide the TB control program, and we however need further investigation to confirm the reliability of the present findings.
Elwira Sieniawska
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Despite the successes in the development of diagnosis and treatment of this disease, it still poses a significant threat to humanity, especially in countries with an average and low level of healthcare de…
Hamidah Hussain, Amyn A. Malik
Preventing tuberculosis infection from progressing to tuberculosis disease is a crucial component of the goal to eliminate tuberculosis. When deciding on the use of tuberculosis preventive therapy among household contacts, policy makers regularly ask questions, such as whether tu…
Christoph Lange, Anca Vasiliù, Anna M. Mandalakas
Tuberculosis is the leading cause of death attributed to a single infectious pathogen worldwide. Despite the availability of anti-tuberculosis therapies for more than half a century, the number of people affected by tuberculosis reached a historical peak in 2021.1WHOGlobal tuberc…
Yue Wang, Weibing Wang
Given that existing tuberculosis interventions and strategies are not going to enable achievement of WHO's goal to eliminate tuberculosis by 2050,1Xu K Ding C Mangan CJ et al.Tuberculosis in China: A longitudinal predictive model of the general population and recommendations for …
Michael Reid, Eric Goosby, Sebastian Kevany
…r High-Level Meeting of all UN member states made defeating tuberculosis a global political priority.1Stop TB PartnershipUN high-level meeting on TB–key targets and commitments.http://www.stoptb.org/global/advocacy/unhlm_targets.aspDate: 2018Date accessed: December 12, 2018Google…
Pradeep M Muragundi
Introduction: Extensively Drug-Resistant Tuberculosis (XDR-TB) is a recent challenge for tuberculosis control program. The absence of the functional drugs and high rate of the failure in treatment and mortality rate also high jeopardize for epidemiology. Its prevalence is unknown…
Gunar Günther, Lorenzo Guglielmetti, Claude Leu, Christoph Lange, Frank van Leth, et al.
…ckground Access to comprehensive diagnostics and novel anti-tuberculosis medicines is crucial to improve tuberculosis control at times of emerging Mycobacterium tuberculosis drug resistance. Methods We investigated access to genotypic and phenotypic M tuberculosis drug susceptibi…
Victor Næstholt Dahl, Simon Tiberi, Delia Goletti, Christian Wejse
… countries healthcare systems will be strained. Even though tuberculosis (TB) incidence rates had been gradually decreasing over the years in Ukraine and Russia with rates of 73 and 46 per 100,000 individuals in 2020 (WHO 2021WHOGlobal tuberculosis report 2021. World Health Organ…
Christoph Lange, Keertan Dheda, Dumitru Chesov, Anna M. Mandalakas, Zarir Udwadia, et al.
…lopment and in implementation, to reduce the drug-resistant tuberculosis epidemic.1Lange C Dheda K Chesov D Mandalakas AM Udwadia Z Horsburgh Jr, CR Management of drug-resistant tuberculosis.Lancet. 2019; 394: 953-966Summary Full Text Full Text PDF PubMed Scopus (128) Google Scho…
Ameya D. Bendre, Pooja Singh, Swati Jaiswal
Tuberculosis: Recent Updates in Basic Research, Drug Discovery and TreatmentAmeya D. Bendre1, Pooja Singh2*, Swati Jaiswal3*1.Department of Chemistry, S. P. Pune University (formerly known as Pune University), Ganeshkhind, Pune 411007, IndiaCurrent affiliation: Gennova Biopharmac…
Samantha Pillay, Geraint Davies, Marty Chaplin, Margaretha de Vos, Samuel G. Schumacher, et al.
…ibility testing (DST). DST determines whether Mycobacterium tuberculosis bacteria are susceptible or resistant to drugs. Xpert MTB/XDR is a rapid nucleic acid amplification test for detection of tuberculosis and drug resistance in one test suitable for use in peripheral and inter…
Ismail NA, Mvusi L, Nanoo A, Dreyer A, Omar SV, et al.
…tionately high number of cases of multidrug-resistant (MDR) tuberculosis and extensively drug-resistant (XDR) tuberculosis. We sought to estimate the prevalence of resistance to tuberculosis drugs in newly diagnosed and retreated patients with tuberculosis provincially and nation…
L.M. Zahaba, M.S. Opanasenko, І. В. Ліскіна, О. V. Теreshkovych, O.O. Melnyk, et al.
…. To clarify the clinical forms of drug-resistant pulmonary tuberculosis with surgical treatment and their relationship with the morphological activity of specific inflammation and the detection of Mycobacterium tuberculosis (MBT) in the surgical material. MATERIALS AND METHODS. …
Ekramy Elmorsy, Basil D. M. Alruwaili, Hatem R. H. Alrwaili, Anwar S. J. Alrawaili, Abdulelah Alanazi, et al.
Background & objectives: Tuberculosis (TB) continues to be a significant global health issue, as an increasing number of individuals are presenting with severe, life-threatening conditions that require admission to intensive care units (ICUs). The management of critical care …
Amish Talwar, Clarisse A. Tsang, Sandy F. Price, Robert Pratt, William L. Walker, et al.
This report reviews the current status of tuberculosis in the United States, noting the declining incidence and describing the populations with the greatest prevalence. This report reviews the current status of tuberculosis in the United States, noting the declining incidence and…
Gudisa Bereda
Medication-resistant tuberculosis is a considerable across-the-board public health challenge that menace’s the substantial advance made in tuberculosis heedfulness and precluding in current decades. Multidrug-resistant tuberculosis is caused by organisms that are resistant to the…
Yaşar Durmuş S, Tanır G, Aydın Teke T, Kaman A, Yalçınkaya R, et al.
Background Smear-positive adults with tuberculosis are the main source of childhood tuberculosis. The evaluation of children exposed to tuberculosis and determination of the disease stages are the cornerstones of managing childhood tuberculosis. Aim To determine the frequency of …
Margherita Bracchi, Clare van Halsema, Frank A. Post, Funmi Awosusi, Alison Barbour, et al.
…f these guidelines is to help physicians manage adults with tuberculosis (TB)/human immunodeficiency virus (HIV) co-infection. Recommendations for the treatment of TB in HIV-positive adults are similar to those in HIV-negative adults. Of note, the term "HIV" refers to HIV-1 throu…
Schnippel K, Ndjeka N, Maartens G, Meintjes G, Master I, et al.
…ddition of bedaquiline to treatment for multidrug-resistant tuberculosis was associated with an increased risk of death in a phase 2b clinical trial, resulting in caution from WHO. Following a compassionate access programme and local regulatory approval, the South African Nationa…
Zhang A, Jumbe E, Krysiak R, Sidiki S, Kelley HV, et al.
Background Rural settings where molecular tuberculosis diagnostics are not currently available need easy-to-use tests that do not require additional processing or equipment. While acid-fast bacilli (AFB) smear is the most common and often only tuberculosis diagnosis test performe…
Abay GK, Abraha BH
Background Tuberculosis is an infectious disease usually caused by Mycobacterium tuberculosis bacteria. The global emergence of mono- or multidrug-resistant tuberculosis and extensively drug-resistant forms of tuberculosis pose a considerable challenge to tuberculosis control pro…
Gudisa Bereda
Mycobacterium tuberculosis strains that are resistant to an elevating number of second-line medicines used to treat multidrug-resistant tuberculosis are becoming a threat to public health worldwide. Recent guidelines recommended at least 20 months of treatment, but recent regimen…