Showing 101–125 of 200 documents
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Renuka Murhar, Sunita Gajbhiye, S.S. Zodpey, Shailesh Lichade
…lones indicating pre-XDR TB. Conclusions: For Mycobacterium tuberculosis detection in extrapulmonary samples, multiple modalities should be employed so that the bacilli in these samples is not missed and the turn-around time is lowered which is a key to TB control strategy.
Xi-Ling Huang, Aliaksandr Skrahin, Pu-Xuan Lu, Sofia Alexandru, Valeriu Crudu, et al.
Abstract Multidrug-resistant tuberculosis (mdrtb) refers to TB infection resistant to at least two most powerful anti-TB drugs, isoniazid and rifampincin. It has been estimated that globally 3.5% (which can be much higher in some regions) of newly diagnosed TB patients, and 20.5%…
Dmytro Butov, Tetiana Butova, N. A. Rudova, Nadiya Sapelnik, Olena Borysova, et al.
… the treatment outcome of patients with multidrug-resistant tuberculosis (TB) and Beijing lineage 2 (BL2) of MTB. <b>Methods:</b> This is a prospective, cohort study of all patients with culture-confirmed pulmonary TB and MTB resistance to at least isoniazid and rifampicin. Bacte…
Shaik J, Pillay M, Moodley J, Jeena P
…demiology and drug susceptibility patterns of Mycobacterium tuberculosis (MTB) of children and their household contacts (HHC) in Umlazi, a high TB-burden township in South Africa. Sixty eight MTBRifPLUS positive TB-infected children (TIC) (≤14 years) and 111 HHC were enrolled. Dr…
Supriya Dhakne
Introduction: Multidrug‑resistant tuberculosis (MDR‑TB) has created a significant health problem in most of the countries, and it is an obstacle to effective TB control. Aims and Objectives: The study aims to study the prevalence of MDR‑TB among new cases, retreatment cases and t…
Benremila D, Djoudi F, Gharout-Sait A, Kheloufi S, Spitaleri A, et al.
…un on the Illumina NextSeq500 System. Among 82 isolates, 21 tuberculosis (TB) isolates (25.6%) were drug resistant, including 10 MDR and 4 pre-extensively drug-resistant (XDR)-TB. The mutation Ser315Thr in the kat G gene was confirmed in 15 isolates. In rpo B, Ser450Leu and His44…
Argita D. Salindri, Maia Kipiani, Nino Lomtadze, Nestani Tukvadze, Zaza Avaliani, et al.
…e relationship between common comorbidities in persons with tuberculosis (TB) (including human immunodeficiency virus [HIV], diabetes, and hepatitis C virus [HCV]) with post-TB mortality. We conducted a retrospective cohort study among persons who initiated treatment for rifampic…
Pooja Sadana, Vishal Verma, Priyanka Devgun
…reatment outcome. Other factors like sex, residence, typeof tuberculosis and the HIV status of the patient did not affect the treatment outcome.
Pooja Sadana, Vishal Verma, Priyanka Devgun
…eatment outcome. Other factors like sex, residence, type of tuberculosis and the HIV status of the patient did not affect the treatment outcome.
Manisha Nagpal, Sarthak Chawla, Priyanka Devgun, Naresh Chawla
Background: Multidrug resistant tuberculosis (MDR-TB) has become a major public health problem. It is associated with significant morbidity and mortality. The treatment success rate worldwide is around 50%.Methods: This cross-sectional study was conducted on all MDR-TB patients w…
Ketema T, Tadesse M, Bonsa Z, Balay G, Kebede W, et al.
…f drug resistance, including resistance to second-line anti-tuberculosis (TB) drugs, is crucial for the effective control and management of pre-extensively drug-resistant TB (pre-XDR-TB) and extensively drug-resistant TB (XDR-TB). The Xpert MTB/XDR assay is the WHO recommended me…
Meskini M, Zamani MS, Amanzadeh A, Bouzari S, Karimipoor M, et al.
…d-dendritic cells (mo-DCs) in connection with Mycobacterium tuberculosis (MTB) infection, with particular emphasis on pro/ anti-inflammatory genes. Methods In the context of this investigation, mo-DCs were infected by various active strains of MTB (Rifampicin-resistant [RIFR], H3…
Buziashvili M, Davtyan H, Sereda Y, Denisiuk O, Gozalov O, et al.
Considering the complexity of second-line anti-tuberculosis (TB) treatment regimens, the management of drug-resistant TB (DR-TB) in Georgia remains a major challenge. Since the introduction of new and repurposed anti-TB medications, the implementation of active TB Drug Safety Mon…
Human Sciences Research Council
…'s population of the human immunodeficiency virus (HIV) and tuberculosis (TB) co-infected individuals. It has been estimated that approximately 60% of people with TB are co-infected with HIV (WHO 2012). Co-infected individuals have almost double the chances of getting multi-drug …
Girase R, Ahmad I, Patel H
…st 35 years. It exhibits bacteriostatic efficacy against M. tuberculosis and is a crucial constituent of the BPaL regimen (Bedaquiline, Pretomanid, and Linezolid), which was authorized by the FDA in 2019 for the treatment of XDR-TB or MDR-TB. Despite its unique mechanism of actio…
Salindri AD, Kipiani M, Lomtadze N, Tukvadze N, Avaliani Z, et al.
…e relationship between common comorbidities in persons with tuberculosis (TB) (including human immunodeficiency virus [HIV], diabetes, and hepatitis C virus [HCV]) and post-TB mortality. We conducted a retrospective cohort study among persons who initiated treatment for rifampici…
Kuchukhidze G, Baliashvili D, Adamashvili N, Kasradze A, Kempker RR, et al.
…mong patients with multidrug and extensively drug-resistant tuberculosis (M/XDR TB). We aimed to identify long-term clinical outcomes of patients who were LFU during second-line TB treatment. Methods We conducted a follow-up study among adults who received second-line TB treatmen…
Matúš Dohál, Olha Konstantynovska, Michaela Hromádková, Marek Štrba, Karolína Doležalová, et al.
…d migration into Central Europe, raising concerns regarding tuberculosis (TB) spread. **METHODS:** We conducted a molecular-epidemiological study including all Ukrainian migrants with culture-confirmed TB in Slovakia and the Czech Republic between September 2021 and December 202…
Maïssala Zoutené, Akouvi Mawussé Edjodjinam Ako, Koffi Atsu Aziagbe, Narcisse Viani Gateu Tadjom, Tété Amento Stéphane Adambounou, et al.
…IVES:** The increasing burden of extensively drug-resistant tuberculosis (XDR-TB) undermines global TB control efforts. **METHODS:** This was a case series study conducted from January 1, 2007, to December 31, 2024, in the Department of Pulmonology at Sylvanus Olympio University…
Prasitpuriprecha C, Jantama SS, Preeprem T, Pitakaso R, Srichok T, et al.
…rm for determining if a patient is positive or negative for tuberculosis and classifying several types of drug resistance. The constructed model is evaluated and compared to current methods described in the literature. The proposed model was assessed using two datasets of chest X…
Desai U, Joshi JM
Background Drug-resistant tuberculosis (DR-TB) is a global problem with only 52% reported cure rate. Extrapulmonary (EP) DR-TB poses a formidable diagnostic, therapeutic challenge. We aimed to study their clinical profile and treatment outcomes under the programmatic setting. Mat…
Zhao LL, Huang MX, Xiao TY, Liu HC, Li MC, et al.
…valence, risk and genetic characteristics of drug-resistant tuberculosis (TB) from a tertiary care TB hospital in China. Patients and methods We carried out a retrospective study including isolates from 189 patients with pulmonary TB at Fuzhou Pulmonary Hospital. All isolates fro…
Zubeida Salaam-Dreyer, Elizabeth M. Streicher, Frederick A. Sirgel, Fabrizio Menardo, Sònia Borrell, et al.
Abstract Rifampicin mono-resistant TB (RMR-TB) constitutes 38% of all rifampicin-resistant TB (RR-TB) in South Africa and is increasing. We aimed to compare RMR-TB with multidrug-resistant TB (MDR-TB) within a high TB, RR-TB and HIV burden setting. Patient-level clinical data and…
Xiaowei Dai, Chung‐Yi Li, N H Wang, S S Chen, Li Tian, et al.
The prevalence of fluoroquinolones (LFX and MFX) resistance in rifampicin-resistant MTB is very serious. LFX and MFX show incomplete bidirectional cross-resistance. BDQ and LZD have the most promising future in the treatment of MDR-TB. Improve drug-resistance testing will help to…
H J Chen, Xubin Zheng, Y Wang, Jinze Li, Biao Xu
Number of patients under drug resistance surveillance and the detection of MDR/XDR-TB trended to increase in Guizhou province from 2012 to 2019. The detection rate of MDR/XDR-TB in high-risk groups was higher than low-risk groups.