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Concepcion NDP, Laya BF, Andronikou S, Abdul Manaf Z, Atienza MIM, et al.
Tuberculosis (TB) remains a global health problem and is the second leading cause of death from a single infectious agent, behind the novel coronavirus disease of 2019. Children are amongst the most vulnerable groups affected by TB, and imaging manifestations are different in chi…
Chatterjee S, Banta A
Introduction Pediatric spinal tuberculosis is characterized by rapid bone destruction and carries the risk of rapid onset neurological deficits and severe deformity of the spine. Behavior of spinal deformity over time is affected by growth of spine. Owing to this dynamic behavior…
Santiago Atehortúa-Muñoz, Andrea Cardona-Moreno, Laura Niño-Quiroga, Javier Orlando Contreras-Ortiz, Catalina Arango-Ferreira
Abstract Objective Diagnosis of pulmonary tuberculosis (PTB) in pediatrics is a challenge due to the paucibacillary condition of the disease in this population, low sputum expectoration, and diverse unspecific symptomatology. Mycobacterial isolation through culture remains a prio…
Dhruv Gandhi, Meenakshi Dey, Sonal Patil, Dhruv Mamtora, Ira Shah
Abstract Background The diagnosis of pediatric tuberculosis (TB) remains challenging due to difficulties in specimen collection and the paucibacillary nature of the disease. While Mycobacteria Growth Indicator Tube (MGIT) culture is the gold standard, its long turnaround time lim…
Battaglia CSP, Parente AAAI, Luiz RR, Aurilio RB, Pinheiro MAS, et al.
Objectives To evaluate the contribution of Ultra to the diagnosis of pediatric pulmonary tuberculosis (PTB). Methods We analyzed prospective data from children and adolescents with presumed PTB whose specimens were tested with Ultra between January 2020 and December 2022. Diagnos…
Kaba Ö, Kara M, Odacılar CA, Kamer İ, Sütçü M, et al.
Aim Extrapulmonary tuberculosis is observed more frequently and leads to complications with a higher rate in children compared with adults because the risk of lymphohematogen spread is higher. In this study, the clinical, laboratory, and radiologic findings and treatment outcomes…
Heather J. Zar, Mark P. Nicol
Pediatric tuberculosis is a global concern, with children estimated to account for 10% to 15% of the overall case load, representing almost 1 million cases annually. However, modeling estimates indicate that only 30% of childhood tuberculosis cases are diagnosed and notified.1 Di…
Mgode GF, Cox CL, Mwimanzi S, Mulder C
Background Tuberculosis (TB) diagnosis in children is a challenge with up to 94% of children with TB treated empirically in TB high-burden countries. Therefore, new diagnostic tests are needed for TB diagnosis. We determined the performance of trained rats in the diagnosis of ped…
Sushil Kumar Kabra
Diagnosis of Tuberculosis in children is challenging. Major challenge is because of difficulty in obtaining representative airway samples and paucibacillary nature of illness. Significant improvement occurred over past few years. However, the sensitivity and specificity of labora…
Kaur H, Guglani V, Singhal L, Randev S, Kumar P, et al.
Background Microbiological diagnosis of pediatric tuberculosis (TB) using conventional microbiological techniques has been challenging due to paucibacillary nature of the disease. Molecular methods using cartridge-based tests like Xpert, have immensely improved diagnosis. A novel…
Druszczynska M, Seweryn M, Wawrocki S, Pankowska A, Kulbachko A, et al.
Background Accurate diagnosis of tuberculosis (TB) in children continues to be challenging, primarily due to the low bacterial load characteristic of the disease and the obstacles in collecting sputum samples. Furthermore, detecting cases of latent Mycobacterium tuberculosis (M.t…
Kanjanaphan T
Background Tuberculosis (TB) is an important public health problem, and airborne transmission is easily transmitted. Latent TB infection (LTBI) detection and treatment is the key strategy to prevent TB. Objective This study aimed to perform contact investigation of LTBI in health…
Yalçın Kara
Tuberculosis is an infectious disease caused by the Mycobacterium tuberculosis bacteria with high mortality and morbidity. Especially, delay in diagnosis and treatment of childhood tuberculosis causes an increase in adult tuberculosis. According to the World Health Organization, …
Jakhar S, Bitzer AA, Stromberg LR, Mukundan H
Tuberculosis (TB) is a major public health concern for all ages. However, the disease presents a larger challenge in pediatric populations, partially owing to the lack of reliable diagnostic standards for the early identification of infection. Currently, there are no biomarkers t…
Dilia Fontalvo-Rivera, Maria Daniels-García, Jesly Doria-Atencia, Karen Tous-Barrios, Liliana Molinares-Núñez, et al.
**UNLABELLED:** The diagnosis of extrapulmonary tuberculosis (EPTB) in children is challenging due to the variable and nonspecific manifestations and the low rate of M. tuberculosis isolations which delayed diagnosis, leading to an increase in cases with unfavorable outcomes. **…
Zhu J, Chen N, Shang Y, Feng Y
… distress syndrome (ARDS) is a rare complication of miliary tuberculosis, particularly in pediatric patients. Comorbidities and delayed diagnosis can worsen the prognosis of patients with miliary tuberculosis. A 12-year-old girl presented with fever for 20 days, and cough and tac…
Elfarissi MA, Dahamou M, Dehneh Y, Lhamlili M, Khoulali M, et al.
Background Pediatric sellar-suprasellar tuberculosis is a rare form of tuberculosis that affects the pituitary gland and surrounding areas in the brain. It can be difficult to diagnose based on clinical and radiological signs alone, as they can be similar to other pituitary masse…
Min Yu, Qi-Jun Jiang, Yuqing He, Fei Zhao, Tang-Ming Jin, et al.
Clinical manifestations of pediatric pulmonary tuberculosis (PTB) are atypical, making diagnosis challenging. This study aims to analyze the clinical characteristics of PTB to provide constructive suggestions for the diagnosis of PTB. A retrospective analysis was conducted on ped…
Marcy O, Goyet S, Borand L, Msellati P, Ung V, et al.
Background There is no gold standard for tuberculosis diagnosis in children. Clinical Case Definitions for Classification of Intrathoracic Tuberculosis in Children were proposed by international experts in 2012 and updated in 2015. We aimed to compare the 2012 and 2015 Clinical C…
M.J. Cavaco, Sofia Giusti Alves, L. Mateus, André Nunes, Ricardo Cordeiro, et al.
<b>Introduction:</b> Early diagnosis of tuberculosis (TB) is essential to achieve cure and to reduce disease transmission. Total diagnostic delay (TDD) can be divided in patient delay (PD - from symptoms onset to seeking a health care facility) and health system delay (HSD - from…
Alexandra R Linn, Andrew P. Steenhoff
…ground The WHO currently estimates that at least a third of pediatric and adolescent tuberculosis cases go untreated or incompletely treated each year. Many cases are detected but lost to follow-up due to underreporting to national or private surveillance systems. Methods We cond…
Lo Vecchio A, Scarano SM, Amato C, Spagnuolo MI, Bruzzese E, et al.
The outbreak of COVID-19 resulted in a decrease in tuberculosis notification rates globally. We compared tuberculosis incidence rates and disease severity in children seen in our centre prior and during COVID-19 pandemic.We performed a cohort study enrolling children aged under 1…
Srabani Banerjee, Melissa Severn
Tuberculosis (TB) is one of the top 10 causes of death, worldwide. Worldwide 10 million people developed TB in 2017, (i.e.,133 cases per 100,000).– However, only 6.4 million cases were reported to WHO, indicating that 36% of cases were undiagnosed or not reported. According to a …
Patricia Comella-del-Barrio, José Luis Izquierdo-García, Ramón Campos‐Olivas, Clara M. Santiveri, Jesús Ruı́z-Cabello, et al.
Children’s paucibacillary tuberculosis (TB) and their difficulty to expectorate leads to low diagnostic sensitivity. Most TB in children are diagnosed by clinical scoring systems limited by the TB clinical presentation. Pediatric TB diagnosis research should be focused on new bio…
Ahang Hasan Mawlood
Background and objective: M. tuberculosis is one of the main causes of morbidity and mortality in many countries and is considered a priority global health problem. Although it is a curable disease, every year about nine million people develop active disease, and two million die …