Showing 101–125 of 200 documents
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Foster N, Tadesse AW, McQuaid CF, Gosce L, Abdurhman T, et al.
…The ASCENT-Ethiopia study is a three-arm cluster randomised trial assessing two DATs with differentiated care for supporting tuberculosis treatment adherence in Ethiopia. This study is part of the ASCENT consortium, assessing DATs in South Africa, the Philippines, Ukraine, Tanzan…
Wekesa C, Sekaggya-Wiltshire C, Muyanja SZ, Lume I, Nabaggala MS, et al.
…nducting a non-inferiority open-label randomized controlled trial to compare adherence to MDR-TB treatment among patients on self-administered therapy (measured by Medication Events Monitoring System (MEMS) technology) with a control group on DOT. Methods We plan to enrol 164 new…
Tanue EA, Nsagha DS, Theophile NN, Assob JCN
…creasing use of this device. Objective The main aim of this trial is to assess whether sending weekly motivational text messages (SMS) through mobile phones versus no text messaging will improve retention in care and promote adherence to treatment and health outcomes among patien…
Mahasha PW, Ndwandwe DE, Mavundza EJ, Shey M, Wiysonge CS
… of Mycobacterium bovis . Evidence from previous randomised trials show that the efficacy of primary BCG vaccination against pulmonary TB ranged from no protection to very high protection. In addition, some studies suggest a benefit of BCG revaccination. For example, a recent tri…
Nanyunja G, Kadota JL, Namale C, Hudson M, Nalugwa T, et al.
…l protection programs for eligible TB-affected individuals. Trial Registration: Pan African Clinical Trials Registry (PACTR201906852160014).
Pan M, Liu W, Zhang Z, Li T, Xie W
…, providing a reference for the rational use of ciprofol in clinical practice. Methods PTB patients who underwent bronchoscopy examination and treatment at The Third People's Hospital of Changzhou between May 2023 and June 2023 were selected and divided into four groups using a s…
Murphy-Okpala N, Eze C, Ossai EN, Agu CI, Ezenwosu I, et al.
…ia and similar settings in low-and middle-income countries. Trial registration Pan African Clinical Trial Registry PACTR202309676675265.
Naomi Chapman, Vinícius Cavalheri, Elizabeth F. Smith, Jamie Wood, Luke W. Garratt, et al.
…utum. METHODS: This was a non-blinded randomised controlled trial where adults hospitalised with a CF exacerbation were allocated to an experimental intervention (EIx; MetaNeb) or a control intervention (CIx; their usual ACT). Both groups underwent twice-daily supervised airway c…
Mouquan Shen, Li Guo, Ya Li, Ruitong Gao, Xin Sui, et al.
…D ANALYSIS: We propose a single-blind randomized controlled trial using 75 hospitalized patients diagnosed with COPD with excessive sputum production. The patients will be divided into three groups. The intervention group will receive active cycle of breathing techniques combined…
Ying Hu, Zhiqiang Chen, Jing Zeng, Shouyan Zheng, Liujuan Sun, et al.
…lls to Tregs under certain conditions. However, no relevant clinical studies have been reported on the association between IDO activity and Th17/Treg imbalance in children with allergic asthma. The goal of this study was to test whether indoleamine 2,3 dioxygenase (IDO) participa…
Imran M, Khan SA, Asdaq SMB, Almehmadi M, Abdulaziz O, et al.
… antituberculosis agents. A few DprE1 inhibitors are in the clinical trial for tuberculosis (TB), including macozinone. This review highlights the discovery, developmental status, clinical studies, patents, and prospects of macozinone (MCZ). The patent and non-patent literature s…
Christopher A. Berger, R. Crowder, A. Kityamuwesi, Noah Kiwanuka, M. Lamunu, et al.
… We conducted a pragmatic, stepped-wedge cluster randomized trial including all adults treated for drug-susceptible pulmonary TB at 18 health facilities across Uganda over eight months (December 1, 2018-July 31, 2019). Facilities were randomized to switch from routine (control pe…
Gashu KD, Gelaye KA, Lester R, Tilahun B
… home. Methods We conducted a two-arm randomised controlled trial on adult patients with TB during the continuation phase. In the intervention arm, patients received routine care plus phone-based weekly pill refilling and daily medication reminders. In the control arm, participan…
Lifan Zhang, Yujie He, Wenwen Wang, Lijun Wu, Xiaoxia Zuo, et al.
…cted a multicenter, open-label, randomized, non-inferiority trial at nine tertiary general hospitals in China. Eligible participants were adults (18-70 years) with high-risk rheumatic diseases and LTBI undergoing immunosuppressive therapy. Patients were randomized (1:1) to receiv…
Bhargava A, Bhargava M, Meher A, Teja GS, Velayutham B, et al.
…ia. RATIONS is a field-based, cluster-randomised controlled trial evaluating the effect of providing nutritional support to household contacts of adult patients with microbiologically confirmed pulmonary tuberculosis in Jharkhand, India, on tuberculosis incidence. The patient coh…
Van Hoving DJ, Griesel R, Meintjes G, Takwoingi Y, Maartens G, et al.
…ential sources of heterogeneity in test accuracy, including clinical setting, ultrasound training level, and type of reference standard. Search methods We searched for publications in any language up to 4 April 2019 in the following databases: MEDLINE, Embase, BIOSIS, Science Cit…
Huang-Shen Lin, Ming‐Shyan Lin, Yu‐Shiun Tsai, Yu‐Sheng Lin
…LHIV. Methods We searched PubMed, Embase, Cochrane library, clinicaltrials.gov, and the International Clinical Trials Registry Platform for all literature and ongoing trials from their inception until November 30th, 2022. We performed a meta-analysis of the efficacy, adhesion rat…
Fernández-Ruiz M, Aguado JM
…ndications of available agents are reviewed, as well as the clinical evidence coming from clinical trials and observational registries. We discuss the impact of patient- and disease-related factors influencing the occurrence of infection. Finally, strategies for risk minimization…
Tamuzi JL, Ayele BT, Shumba CS, Adetokunboh OO, Uwimana-Nicol J, et al.
… HIV/TB co-infected or TB patients, screening algorithm and clinical management. Methods We conducted an electronic search of potentially eligible studies published in English in the Cochrane Controlled Register of Trials, PubMed, Medrxiv, Google scholar and Clinical Trials Regis…
Nicola Foster, Amare Worku Tadesse, M Belachew, Mamush Sahlie, Christopher Finn McQuaid, et al.
…fectiveness analysis using data from the cluster randomised trial that evaluated the implementation of labels and pillbox followed by differentiated care to support tuberculosis treatment adherence in 78 health facilities in Ethiopia. We estimated the costs, cost per disability-a…
Gong X, He Y, Zhou K, Hua Y, Li Y
…ntly improve the accuracy of tuberculosis (TB) detection in clinical settings, with advanced sensitivity and specificity. Early detection of TB can be challenging, but Xpert has improved the efficacy of the diagnostic process. Nevertheless, the accuracy of Xpert varies according …
Amare W Tadesse, Mamush Sahile, Nicola Foster, Christopher Finn McQuaid, Gedion Teferra Weldemichael, et al.
…rrence. **METHODS:** We did a pragmatic cluster-randomised trial in Ethiopia. 78 health facilities (clusters) were randomised (1:1:1) to smart pillbox, medication labels, or standard of care. Adults aged 18 years or older with drug-sensitive pulmonary tuberculosis on a fixed-dos…
Bediang G, Stoll B, Elia N, Abena JL, Geissbuhler A
…between the fifth and the sixth months of treatment. Future trials should focus on reducing the dropout rate. Trial registration The trial was registered on the Pan-African Clinical Trials Registry ( PACTR201307000583416 of 22 July 2013) and the protocol was published.
Jorge D. Machicado, Georgios I. Papachristou
… field of pancreatology, this has translated into increased clinical and research efforts to decrease the burden, morbidity, and mortality associated with benign inflammatory disorders and pancreatic cancer. As a result, there has been a tremendous progress in our understanding o…
Manabu Suzuki, Satoki Hatano, Chie Morita, Akinari Tsukada, Akane Ishida, et al.
…ucted a retrospective observational study to understand the clinical characteristics of patients with cryptogenic hemoptysis (CH). **METHODS:** The clinical characteristics, angiographic findings, and immediate and long-term efficacies of BAE were retrospectively analyzed in 36 …