Showing 101–125 of 200 documents
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Peng L, Ma W, Zhong L, Yang J, Wu H, et al.
The aim of this study was to evaluate the diagnostic accuracy of the IGRA, TST, and TBST by combining diagnostic test accuracy (DTA) analysis and network meta-analysis (NMA) to increase the reliability and accuracy of diagnostic methods and promote the eradication of TB. An elect…
Liu XT, Dong XL, Zhang Y, Fang P, Shi HY, et al.
Background Pleural effusions occur for various reasons, and their diagnosis remains challenging despite the availability of different diagnostic modalities. Medical thoracoscopy (MT) can be used for both diagnostic and therapeutic purposes, especially in patients with undiagnosed…
Barış Çil, Mehmet Sinan Bodur, Mehmet Kabak
**BACKGROUND:** The diagnosis of extrapulmonary tuberculosis (EPTB) often depends on advanced imaging, invasive tissue sampling, and multidisciplinary referral pathways. These complex, procedure-dependent diagnostic processes are particularly vulnerable to disruption during perio…
Zhang M, Li D, Hu ZD, Huang YL
Tuberculosis pleural effusion (TPE) is common in clinical practice, and its diagnosis remains a challenge for clinicians. Ziehl-Neelsen staining, PE Mycobacterium tuberculosis culture, and biopsy are the gold standards for TPE diagnosis; however, they are time-consuming, invasive…
Kay A, Vasiliu A, Carratala-Castro L, Mtafya B, Mendez Reyes JE, et al.
…Reliance on sputum as the primary specimen for tuberculosis diagnostics contributes to this diagnostic gap. We evaluated the diagnostic accuracy and additive yield of a novel stool quantitative PCR (qPCR) assay for the diagnosis of tuberculosis in three countries in Africa with h…
Meryem Sena Kaya, Sibel Yıldız Kaya, Rıdvan Karaali, Günay Can, İlker İnanç Balkan, et al.
**BACKGROUND:** Fever of unknown origin (FUO) remains a significant diagnostic challenge. Changes in patient populations and diagnostic technologies may shift the spectrum of underlying etiologies. This study aimed to examine recent FUO cases at a single tertiary center to identi…
Miller AC, Arakkal AT, Koeneman SH, Cavanaugh JE, Polgreen PM
Objectives A first step in studying diagnostic delays is to select the signs, symptoms and alternative diseases that represent missed diagnostic opportunities. Because this step is labor intensive requiring exhaustive literature reviews, we developed machine learning approaches t…
Tan Kah Shien, Mas Fazlin Mohamad Jailaini, Azat Azrai Azmel, Vijayan Munusamy, Arvindran Alaga, et al.
**BACKGROUND:** Tuberculous pleural effusion (TPE) remains a diagnostic challenge, particularly in tuberculosis-endemic regions. Pleural fluid adenosine deaminase (pfADA) is widely used as a diagnostic biomarker; however, its optimal cutoff value may vary depending on the epidemi…
Xuegang Zhou, Nan Tang, Xiuqing Liao, Xiaoli Bao
**BACKGROUND:** Bronchoalveolar lavage fluid (BALF) Xpert Mycobacterium tuberculosis and rifampicin resistance (Xpert MTB/RIF) is increasingly used as an important diagnostic method for sputum smear-negative pulmonary tuberculosis (PTB) in many countries. However, no studies have…
Jean de Dieu Iragena, Achilles Katamba, Anandi Martin, Moses Joloba, Willy Ssengooba
…CT Background The implementation of rapid tuberculosis (TB) diagnostics is essential for TB control. Factors influencing their uptake in Africa are unknown. We conducted a survey to collect the status and document Predisposing, Enabling, and Need (PEN) factors influencing so that…
Brooke E Nichols, Alexandra de Nooy, Naseem Cassim, Lucia Hans, Manuel Pedro da Silva, et al.
ABSTRACT To ensure there is adequate investment into diagnostics, an understanding of the magnitude of impact and return on investment is necessary. We therefore sought to understand the health and economic impacts of the molecular diagnostic programme in South Africa, to deepen …
Niti Sureka, Smriti Sharan, Charanjeet Ahluwalia, Sana Ahuja, Sunil Ranga
**BACKGROUND:** Pulmonary diseases represent a significant global health challenge, underscoring the need for accurate diagnostic methods to ensure effective management. Bronchoalveolar lavage (BAL) is an essential diagnostic tool, providing valuable insights into various lung co…
Fahriye Hakan-Groen
The Dutch national uveitis guideline advises on the diagnostic work-up of uveitis patients. However, some of the included diagnostic tests as well as their value in the work-up for new uveitis patients were so far not systematically studied. \nWith the rise of novel diagnost…
Ntinginya NE, Kuchaka D, Orina F, Mwebaza I, Liyoyo A, et al.
…portunities to maximise uptake and utilisation of molecular diagnostics in routine healthcare settings. Methods Using the implementation of WHO approved TB diagnostics, Xpert Mycobacterium tuberculosis /rifampicin (MTB/RIF) and Line Probe Assay (LPA) as a benchmark, we evaluated …
He Y, Zhu Z, Chen Y, Chen F, Wang Y, et al.
Objectives Differentiating Crohn's disease (CD) from intestinal tuberculosis (ITB) remains a diagnostic challenge. Misdiagnosis carries potential grave implications. We aimed to develop and validate a novel diagnostic nomogram for differentiating them. Methods In total, 310 eligi…
Wang B, Wang Q, Li M, Yu J, Jiang F, et al.
…t yet discussed in current literature as a means for TB-IAI diagnostics. Here we describe a cohort of patients with TB-IAI diagnosed by mNGS show high efficiency of mNGS for detection of this pathology and present a clinical algorithm supplementing conventional methods for TB-IAI…
Joyce Mulenga, Lonia Mwape, Patricia Katowa-Mukwato
Background Tuberculosis (TB) and human immunodeficiency virus (HIV) constitute the main burden of infectious disease in resource-limited Countries6. Persons infected with HIV are particularly susceptible to tuberculosis, both from the reactivation of latent infection and from new…
Cristina Blanco‐Vázquez, Marta Alonso‐Hearn, Ramón A. Juste, María Canive, Tania Iglesias, et al.
Bovine paratuberculosis (PTB) is a chronic granulomatous enteritis, caused by Mycobacterium avium subsp. paratuberculosis (MAP), responsible for important economic losses in the dairy industry. Current diagnostic methods have low sensitivities for detection of latent forms of MAP…
Srivastava S, Singh PK, Vatsalya V, Karch RC
Objectives Diagnostics is the first step for the treatment and eradication of infectious microbial diseases. Due to ever evolving pathogens and emerging new diseases, there is an urgent need to identify suitable diagnostic techniques for better management of each disease. The suc…
Seki M, Kim CK, Hayakawa S, Mitarai S
…iagnostic methodologies for TB, and the impact of those new diagnostics on TB control in such situations. Moreover, the perspective of TB management based on laboratory examinations is described. Smear microscopy with sputum samples is the only laboratory examination available in…
Assebe LF, Erena AK, Fikadu L, Alemu B, Baruda YS, et al.
…ational TB guideline recommends the primary use of rapid TB diagnostics whenever feasible, there is limited evidence available that assess the efficiency of deploying various diagnostic tools in the country. Hence, this study aims to evaluate the cost-effectiveness of rapid TB/MD…
B Bermawi, Dewi Kurniasari, Ayunda Imaniar, Nurul Hidayatih, Diana Arum Lisnawati, et al.
INTRODUCTION: Tuberculosis (TB) is a serious global health problem in Indonesia, which is the country with the secondhighest TB burden after India. Accuracy in TB diagnosis is the key to effective treatment and decreased transmission rate. One of the latest diagnostic methods is …
Dionysius B. P. Manyakori, Andri Danika
Abstract Wrist tuberculosis (TB) is a rare manifestation of osteoarticular TB that presents substantial diagnostic challenges, particularly in TB-endemic regions. Its insidious onset and nonspecific clinical manifestations frequently lead to misdiagnosis and delayed treatment. Th…
Bermawi B, Kurniasari DW, Imaniar A, Hidayatih N, Lisnawati DA, et al.
Introduction Tuberculosis (TB) is a serious global health problem in Indonesia, which is the country with the secondhighest TB burden after India. Accuracy in TB diagnosis is the key to effective treatment and decreased transmission rate. One of the latest diagnostic methods is i…
Justin Onyebuchi Nwofe, Laura Madukaji, Daniel Chinenyeike Offie, Dickson Adeolu Adetoye, Emmanuel Adewale Ojo, et al.
Abstract Introduction Tuberculosis (TB) diagnosis remains the weakest link in the care cascade, particularly among people living with HIV and AIDS (PLHIV) with advanced HIV disease (AHD), who are often cannot produce quality sputum for standard tests. Urine-based assays such as D…