Showing 76–100 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Jaber AAS, Ibrahim B
…nization (WHO) has reported that Yemen has a high burden of drug resistance and a worrying shortage of implemented diagnostic methods and drug treatment regimens. Therefore, in this study, we evaluated the risk factors associated with multidrug-resistant tuberculosis (MDR-TB) and…
Satyendra N. Shukla, Nitin Bhardwaj, Ashutosh Singh
…has emerged as a health risk due to its ability to adapt to drugs . The emergence of drug-resistant Mtb is affected by factors such as drug-resistant gene mutations, the efficacy of TB treatment, genetic background of the strain, and its ability to adapt to host and specific envi…
Abbas Abel Anzaku
Abstract Background: This study evaluated the prevalence of drug resistant tuberculosis infection among suspected tuberculosis patients attending Asokoro District Hospital (ADH), Abuja, Nigeria. Methods: A total of 301 AFB+/- sputum specimens from suspected TB patients were colle…
Xu P, Li M, Jiang Q, Yang C, Liu X, et al.
Objective Drug resistance is the critical determinant for appropriate tuberculosis (TB) treatment regimens and an important indicator of the local TB burden. We aimed to investigate and compare trends in TB drug resistance in the urban Songjiang District of Shanghai from 2011 to …
Garg RK, Rizvi I, Malhotra HS, Uniyal R, Kumar N
Introduction Drug-resistant tuberculous meningitis has been reported worldwide. Isoniazid mono-resistance is the most frequent cause of drug-resistant tuberculous meningitis, a life-threatening disease. Extensive drug-resistant tuberculous meningitis has also been reported in som…
Li M, Deng B, Huang Y, Li Q, Han J, et al.
To investigate the status of the drug-resistant tuberculosis (DR-TB) among children in Sichuan, and to find out the risk factors and high-risk population related to drug resistance among children. The clinical data of tuberculosis patients ≤14 years old with culture-confirmed tub…
Kidenya BR, Mshana SE, Fitzgerald DW, Ocheretina O
Background Drug resistant Tuberculosis (TB) is considered a global public health threat. Whole-genome sequencing (WGS) is a new technology for tuberculosis (TB) diagnostics and is capable of providing rapid drug resistance profiles and genotypes for epidemiologic surveillance. Th…
Udhaya Kumar S, Saleem A, Thirumal Kumar D, Anu Preethi V, Younes S, et al.
Background and aim The persistence of extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (MTB) continue to pose a significant challenge to the treatment and control of tuberculosis infections worldwide. XDR-MTB strains exhibit resistance against first-line ant…
Chen S, Shang Y, Zheng J, Huo F, Xue Y, et al.
Objectives The co-resistance between bedaquiline and clofazimine raises significant concerns, as they are commonly co-administered as core drugs in drug-resistant TB regimens. The present study aimed to monitor drug resistance-associated gene mutations and the phenotypic change i…
Christoph Lange, Keertan Dheda, Dumitru Chesov, Anna M. Mandalakas, Zarir Udwadia, et al.
…search and development and in implementation, to reduce the drug-resistant tuberculosis epidemic.1Lange C Dheda K Chesov D Mandalakas AM Udwadia Z Horsburgh Jr, CR Management of drug-resistant tuberculosis.Lancet. 2019; 394: 953-966Summary Full Text Full Text PDF PubMed Scopus (1…
Chen X, He G, Wang S, Lin S, Chen J, et al.
…lly feasible tool for timely and comprehensive diagnosis of drug resistance in developed countries. With the increase in the incidence of multidrug-resistant tuberculosis (MDR-TB), second-line anti-TB drugs are gaining importance. However, genetic resistance to second-line anti-T…
Ogwang MO, Imbuga M, Ngugi C, Mutharia L, Magoma G, et al.
Introduction Globally anti-tuberculosis drug resistance is one of the major challenges affecting control and prevention of tuberculosis. Kenya is ranked among 30 high burden TB countries globally. However, there is scanty information on second line antituberculosis drug resistanc…
Gunar Günther, Lorenzo Guglielmetti, Claude Leu, Christoph Lange, Frank van Leth, et al.
…sis control at times of emerging Mycobacterium tuberculosis drug resistance. Methods We investigated access to genotypic and phenotypic M tuberculosis drug susceptibility testing (DST), availability of anti-tuberculosis drugs and calculated cost of drugs and treatment regimens at…
Ei PW, Aung WW, Nyunt WW, Swe TL, Htwe MM, et al.
…nmar. Objectives To determine the proportion of extensively drug-resistant TB (XDR-TB) cases among multidrug-resistant TB (MDR-TB) cases and the mutations that cause resistance to second-line drugs in Myanmar. Design This was a cross-sectional, retrospective study. Multidrug-resi…
О.С. Шевченко, Svitlana Matveyeva, Anna Stepanenko, Olexandra Choporova, Olha Pohorielova
PECULIARITIES OF DRUG-RESISTANT TUBERCULOSIS IN UKRAINE AND KHARKIV REGION 
 Shevchenko O., Matveyeva S., Stepanenko A., Choporova O., Pohorielova O.
 Background. Multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis remain severe epidemic problem…
Che Y, Lin Y, Yang T, Chen T, Sang G, et al.
Setting Controlling drug-resistant tuberculosis in Ningbo, China. Objective Whole-genome sequencing (WGS) has not been employed to comprehensively study Mycobacterium tuberculosis isolates, especially rifampicin-resistant tuberculosis , in Ningbo, China. Here, we aim to character…
Chawla GK, Garg K, Kaur K, Chopra V, Suri R
Background Drug resistant tuberculosis (DR-TB), particularly multidrug resistance (MDR-TB) and extensive drug resistance (XDR-TB) pose a serious threat to public health. This study aimed to identify drug resistance in pulmonary tuberculosis patients and to see their association w…
Jin C, Wu Y, Chen J, Liu J, Zhang H, et al.
…ence of resistant Mycobacterium tuberculosis (MTB) strains. Drug-resistant TB, including mono-drug-resistant TB, multidrug-resistant TB (MDR-TB), and extensively drug-resistant TB (XDR-TB), presents significant public health challenges. Methods We conducted a systematic literatur…
Wei Wang, Yuxin Gao, Yong Gao, Tuantuan Li, Yan Liu, et al.
**OBJECTIVE:** This study aimed to analyze drug resistance patterns and inpatient medication utilization among drug-resistant tuberculosis (DR-TB) patients in Fuyang City (2021-2023), and to identify factors associated with unsuccessful treatment outcomes in multidrug-resistant t…
Hira Ashfaq, Ayesha Humayun, Muhammad Ahmad Naseem, Sarmad Wahaj Siddiqui, Asifa Kamal, et al.
**BACKGROUND:** Globally, the prevalence of drug-resistant (DR-TB) tuberculosis is rising, and Pakistan is currently one of the nations with the highest burden. It is imperative to track changes in the prevalence of DR-TB, particularly the extensively drug-resistant (XDR-TB) tube…
Hasan Ismail Sultan, Ibrahim Khalil Ibrahim
…uberculosis (TB) is an international public health problem. Drug resistant tuberculosis is a considerable global health risk, leading the ongoing TB epidemic and increasing the morbidity and mortality of TB worldwide. Incomplete and insufficient therapeutic regimens can result in…
Chisompola NK, Streicher EM, Muchemwa CMK, Warren RM, Sampson SL
Background The burden of drug resistant tuberculosis in Africa is largely driven by the emergence and spread of multidrug resistant (MDR) and extensively drug resistant (XDR) Mycobacterium tuberculosis strains. MDR-TB is defined as resistance to isoniazid and rifampicin, while XD…
Suman SK, Chandrasekaran N, Priya Doss CG
…b ) and has become increasingly challenging to treat due to drug resistance. The World Health Organization declared TB a global health emergency in 1993. Drug resistance in TB is driven by mutations in the bacterial genome that can be influenced by prolonged drug exposure and poo…
Tuelo Mogashoa, Lucy Mupfumi, Thato Iketleng, Pinkie Melamu, Nametso Kelentse, et al.
Background The emergence and transmission of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis (Mtb) strains is a serious threat to tuberculosis control in Botswana. Early detection of drug-resistant isolates is critical to ensure optimal t…
Al Mahrouqi S, Gadalla A, Al Azri S, Al-Hamidhi S, Al-Jardani A, et al.
…ulation. The present study examined the genetic profile and drug resistance-conferring mutations in Mycobacterium tuberculosis collected from Omanis and expatriates to recognise possible causes of disease transmission. Methods We examined M. tuberculosis cultured positive samples…