Showing 76–100 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Weijia Lin, Zhi Liu, Yaping Zhang, Yanan Yu, Yang Liu, et al.
Objective: To investigate the clinical diagnostic value of TB-IGRA (Tuberculosis-Interferon Gamma Release Assay), PPD (Intradermal Tuberculin Test), TB-DNA-PCR (Tuberculosis-Deoxyribonucleic-Polymerase Chain Reaction) and ADA(Adenosine Aeaminase) in tuberculous pleural effusion. …
Ibrahim Adamu, Nura Umaru, Adamu Mohammed Sani, Ali Adamu Abdullahi, Jabir Hamza Adamu, et al.
**PURPOSE:** Pulmonary tuberculosis (PTB) continues to be a major public health burden, a situation exacerbated by significant diagnostic gaps. Conventional testing relies heavily on sputum samples, but many patients are unable to produce adequate and qualitative sputum. This lim…
Ismail IM, Kibballi Madhukeshwar A, Naik PR, Nayarmoole BM, Satyanarayana S
Background In India, ensuring all Persons with Presumptive TB (PPTB) undergo TB diagnostic tests and initiating all diagnosed TB patients on treatment are two major implementation challenges. Objectives In a coastal district of Karnataka state, South India, to (1) determine the n…
Zou X, Zhu Y, Hu Q, Qi Q, Hua H, et al.
Background To investigate the diagnostic value of bronchial ultrasound-guided transbronchial lung biopsy (EBUS-TBLB) in tuberculous peripheral pulmonary lesions. Methods A total of 770 patients who completed CT imaging and ultrasound bronchoscopy were retrospectively analyzed. Al…
Peewara Thampanyawat, Patsharaporn T. Sarasombath, Anupop Jitmuang, Kamonthip Kunwipakorn
Abstract Background The prevalence of Pneumocystis pneumonia (PCP), primarily affecting immunocompromised individuals, notably those without HIV infection, has been increasing. Diagnosing PCP is challenging due to the lack of a standard definition. Its diagnosis mainly relies on …
Holtgrewe LML, Jain S, Dekova R, Broger T, Isaacs C, et al.
Rapid and accurate point-of-care (POC) tuberculosis (TB) diagnostics are crucial to bridge the TB diagnostic gap. Leveraging recent advancements in COVID-19 diagnostics, we explored adapting commercially available POC SARS-CoV-2 tests for TB diagnosis in line with the World Healt…
Alice Halliday, Pooja Jain, Long Hoàng, Robert Parker, Mica Tolosa-Wright, et al.
Background Tuberculosis (TB) is a devastating disease for which new diagnostic tests are desperately needed. Objective To validate promising new technologies [namely whole-blood transcriptomics, proteomics, flow cytometry and quantitative reverse transcription-polymerase chain re…
Wenhua Gu, Bo Yang, Tongyangzi Zhang, Yiqing Zhu, Wanzhen Li, et al.
Background Finding a simple, effective and rapid diagnostic method to improve the diagnosis of gastroesophageal reflux-induced chronic cough (GERC) is indicated. Our objective was to determine the diagnostic value of the pepsin concentration in saliva and induced sputum for GERC.…
Halliday A, Jain P, Hoang L, Parker R, Tolosa-Wright M, et al.
Background Tuberculosis (TB) is a devastating disease for which new diagnostic tests are desperately needed. Objective To validate promising new technologies [namely whole-blood transcriptomics, proteomics, flow cytometry and quantitative reverse transcription-polymerase chain re…
Sofia Kostoudi, Robert Hammond
…aims to examine and analyze the present and proposed future diagnostics in the identification of latent tuberculosis. Design Systematic Review Methods PubMed and Scopus were scanned as primary databases during May 2022. Exclusion criteria for the papers scanned included patients …
Takashi Okuma, Eri Hagiwara, Ryo Okuda, T. Oda, Ryota Otoshi, et al.
Abstract Background: In asymptomatic patients with pulmonary Mycobacterium avium complex (MAC) disease, sputum culture testing can be challenging, often leading to difficulty in diagnosis. To investigate the usefulness of gastric juice culture, this study examined the clinical ch…
Tushar Garg, Vivek Gupta, Dyuti Sen, Madhur Verma, Miranda Brouwer, et al.
…ompanied by the CHW to a designated government facility for diagnostics. Those with a confirmed TB diagnosis were put on treatment by the CHW and followed-up till treatment completion. All services were provided free of cost and patients were supported throughout the care pathway…
R. Nath, Pranav Ish, Kumari Harshita, Ashish Sethi
…acillary loads, which lower the sensitivity of conventional diagnostics.[7] AI models trained on diverse datasets may help detect subtle radiological or clinical patterns, thus improving case detection in this vulnerable subgroup. Molecular diagnostics are also being transformed …
John Abel, Surya Dharun
…undetected transmission within herds. Advances in molecular diagnostics and non-invasive sampling strategies in human tuberculosis have demonstrated that Mycobacterium tuberculosis DNA can be reliably detected from oral surfaces, including tongue swabs, using PCR-based methods. T…
John Abel, Surya Dharun
…undetected transmission within herds. Advances in molecular diagnostics and non-invasive sampling strategies in human tuberculosis have demonstrated that Mycobacterium tuberculosis DNA can be reliably detected from oral surfaces, including tongue swabs, using PCR-based methods. T…
Yating Zhao, Longting Du, Junli Song, Wei Sun, Yili Chen, et al.
…Our findings provide actionable solutions for optimizing TB diagnostics in diverse healthcare ecosystems, aligning with the WHO's End TB Strategy to ensure equitable access to rapid diagnostics.
Padingani M, Kumar A, Tripathy JP, Masuka N, Khumalo S
Introduction While there are many studies assessing the pre-treatment loss to follow-up (LFU) among tuberculosis patients in public sector, there is no evidence from private-for-profit health sector and pre-diagnostic LFU from Zimbabwe. We aimed to assess the gaps in the cascade …
J Stübler, L Denkmayr, M J Studnicka, P Kaiser-Krug
Abstract Rationale Endobronchial ultrasound-guided (EBUS) TBNA is the current standard for minimally invasive sampling of mediastinal/hilar lymph nodes. However, cytological specimen may not be sufficient for diagnosis requiring preserved tissue architecture. EBUS-guided TBINCB h…
Nichols BE, de Nooy A, Cassim N, Hans L, da Silva MP, et al.
Introduction To ensure there is adequate investment into diagnostics, an understanding of the magnitude of impact and return on investment is necessary. We, therefore, sought to understand the health and economic impacts of the molecular diagnostic programme in South Africa, to d…
Tennis Tomo Camagu Potelwa
In the HIV/TB endemic public care setting of the Western Cape, diagnostic consideration of patients with persistent lymphadenopathy is focused towards extra- pulmonary tuberculosis (EPTB), more than other infectious or malignant causes of lymphadenopathy. We investigated patients…
Suneja M, Beekmann SE, Dhaliwal G, Miller AC, Polgreen PM
Objectives Diagnostic delays are a major source of morbidity and mortality. Despite the adverse outcomes associated with diagnostic delays, few studies have examined the incidence and factors that influence diagnostic delays for different infectious diseases. The objective of thi…
Gustavo Tapia-Sequeiros, Miguel Hueda-Zavaleta, Juan Carlos Gómez de la Torre, Arantsa Hernandez-Vargas, Claudia Barletta-Carrillo, et al.
**BACKGROUND:** Motivation for the study. Peru has a high prevalence of tuberculosis, therefore, it is necessary to use diagnostic methods with high sensitivity and specificity to adequately identify cases and provide timely treatment. Main findings. Our results indicate that, wh…
Yan Z, Wen JX, Wang H, Jiang TW, Huang JH, et al.
Background This study aimed to evaluate the diagnostic accuracy of pleural fluid (PF) lactate dehydrogenase (LDH) to adenosine deaminase (ADA) (LDH/ADA) ratio for tuberculous pleural effusion (TPE). Especially to explore whether the LDH/ADA ratio provides added diagnostic value t…
Zou X, Xu H, Hu Q, Qi Q, Ma X, et al.
Background Microbiological diagnosis of pulmonary tuberculosis (PTB) is hampered by a low pathogen burden, low compliance and unreliable sputum sampling. Although endobronchial ultrasound-guided transbronchoscopic lung biopsy (EBUS-TBLB) has been found to be useful for the assess…
Yifan Tang, Cheng Chen, Mingming Chen, Kai Wang, Sifan Wang, et al.
**BACKGROUND:** Tuberculosis (TB) remains a major public health concern. Despite improved diagnostic tools, delays in TB diagnosis persist and hinder control efforts. **OBJECTIVE:** This study aims to investigate the spatiotemporal patterns of TB diagnostic delay and identify in…