Showing 51–75 of 200 documents
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Diriba G, Alemu A, Tola HH, Yenew B, Amare M, et al.
Background The rise of drug-resistant tuberculosis (DR-TB) has presented a substantial challenge to the national tuberculosis (TB) control program. Understanding the epidemiology of pre-extensively drug-resistant tuberculosis (pre-XDR-TB) could help clinicians to adapt MDR-TB tre…
Li H, Yuan J, Duan S, Pang Y
Tuberculosis (TB) poses a serious threat to public health worldwide since it was discovered. Until now, TB has been one of the top 10 causes of death from a single infectious disease globally. The treatment of active TB cases majorly relies on various anti-tuberculosis drugs. How…
Anita Kumari, Parveen Sharma, Rekha Bansal
…ercular drugs and may result in to extensive drug resistant tuberculosis (XDR-TB) and major challenges for successful outcome. Objective was to study treatment outcome of multi-drug resistant tuberculosis patients on second line anti-tuberculosis drugs at tertiary care hospital a…
Alfonso J. Rodríguez‐Morales, Aula Abbara, Francine Ntoumi, Nathan Kapata, Peter Mwaba, et al.
World Tuberculosis (TB) Day, March 24th, 2023, will commemorate the day in 1882 when Professor Robert Koch announced his discovery of Mycobacterium tuberculosis (Mtb) when TB ravaged Europe. Over a century later, in 1993, the World Health Organization (WHO) declared TB a global h…
Tuelo Mogashoa, Lucy Mupfumi, Thato Iketleng, Pinkie Melamu, Nametso Kelentse, et al.
…nt (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis (Mtb) strains is a serious threat to tuberculosis control in Botswana. Early detection of drug-resistant isolates is critical to ensure optimal treatment and thereby improve treatment outcomes. The objective…
Jan F, Wali S, Sadia S, Akbar MT, Akbar HS, et al.
…as been rapidly spreading in recent years. In new pulmonary tuberculosis patients, rapid spread of MDR-TB and XDR-TB challenging the effectiveness of national TB control programs especially in many low-income countries. This study was aimed to determine the resistance pattern of …
Mercier T, Desfontaine V, Cruchon S, Da Silva Pereira Clara JA, Briki M, et al.
Objective Anti-tuberculosis (antiTB) drugs are characterized by an important inter-interindividual pharmacokinetic variability poorly predictable from individual patients' characteristics. Therapeutic drug monitoring (TDM) may therefore be beneficial for patients with Mycobacteri…
DK Khadka, DS Bam, Prakash Ghimire, Amit Kumar Singh
Introduction: Tuberculosis is still one of the major public health problems in Nepal and multi drug resistant and extensively drug resistant tuberculosis (MDR /XDRTB) additionally has become serious issue. Prompt diagnosis and effective treatment of MDR/XDRTB is urgently needed. …
Elena Ufimtseva, Natalya Eremeeva, Diana Vakhrusheva, Sergey Skornyakov
Tuberculosis (TB) is a significant global health threat, with one-third of the world’s population infected with causative agent <i>M. tuberculosis</i> (<i>Mtb</i>). With the increasing prevalence of multidrug and extensively drug resistant (MDR and XDR) TB, there is a need to stu…
Kunping Cui, Xiaoxiao Zhao, Wei Liu, Lang Bai
**BACKGROUND:** Multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) among those aged 15-49 years pose a severe public health challenge, yet our understanding of the burden of these diseases in this age group remains limited. This study a…
Moo Sang Chong, Kyutaeg Lee
… Among the cases that showed resistance to one or more anti-tuberculosis drugs, 55 patients (33.1%) were resistant to isoniazid (INH) at the time of initial referral, and the rates for the development of resistant anti-tuberculosis drugs were ethambutol (EMB) (26.6%), rifampicin …
Mokrousov I, Vyazovaya A, Levina K, Gerasimova A, Zhuravlev V, et al.
…h control programmes influence the spread of drug-resistant tuberculosis (TB). We analysed the Mycobacterium tuberculosis population structure in Estonia, a high-priority EU country for TB control, to detect the dynamic changes and underlying factors. The study collection include…
Kartik Chadhar
Tuberculosis (TB), despite extensive global efforts for elimination, continues to pose significant public health challenges, particularly in high-burden countries like India. This review explored the isolation of active (open) TB cases as a critical strategy to curb transmission …
Iryna Makoida, Мykola Ostrovskyy, Iryna Kostitska, Оlga Molodovets, Olga Melnyk-Sheremeta, et al.
<bold>Background:</bold> The coexistence of the:tuberculosis(TB) and diabetes mellitus(DM) epidemic, however, complicates the clinical course of both conditions, which negatively impact the quality of life for patient. <bold>Purpose of the study:</bold> to analyze the impact of c…
Ohji R, Shinohara T, Ohji H, Hatakeyama N, Iwamura S, et al.
Drug-susceptibility test (DST) is important for tuberculosis care; however, there are several pitfalls with the procedure. A 70-year-old woman was diagnosed with extensively drug-resistant tuberculosis based on the result of a DST using microdilution method. Because she had no hi…
Mancuso G, Midiri A, De Gaetano S, Ponzo E, Biondo C
…in disease management. Mismanagement of multidrug-resistant tuberculosis (MDR-TB) cases, resulting from intermittent drug use, prescription errors, and non-compliance of patients, has been identified as a critical risk factor for the development of extensively drug-resistant tube…
The WHO Consolidated Guidelines on Tuberculosis (TB), Module 4: Treatment - Drug-Resistant Tuberculosis Treatment 2022 update informs health care professionals in Member States on how to improve treatment and care for patients with drug-resistant TB (DR-TB). This document include…
Chizimu JY, Solo ES, Bwalya P, Kapalamula TF, Mwale KK, et al.
The emergence of pre-extensively drug-resistant tuberculosis (pre-XDR-TB) is a threat to TB control programs in developing countries such as Zambia. Studies in Zambia have applied molecular techniques to understand drug-resistance-associated mutations, circulating lineages and tr…
Monde N, Munyeme M, Chongwe G, Wensman JJ, Zulu M, et al.
Background Drug-resistant tuberculosis has continued to be a serious global health threat defined by complexity as well as higher morbidity and mortality wherever it occurs, Zambia included. However, the paucity of information on drug-susceptibility patterns of both first-line an…
Sheng-Nan Tang, Xi-Ling Huang, Alena Skrahina, Qiu-Ting Zheng, Aleh Tarasau, et al.
…eful in differentiating multidrug-resistant (MDR) pulmonary tuberculosis (PTB) from drug-sensitive (DS) tuberculosis (TB) on chest computed tomography (CT). This study aims to confirm the difference in PN features between DS and MDR patients. **METHODS:** Eastern European (Belar…
David Kajoba Mumena, Geoffrey Kwenda, Caroline Ngugi, Andrew Nyerere
Drug-Resistant Tuberculosis (DR-TB) causes high mortality and morbidity rates globally. DR-TB and COVID-19 pandemic are posing a major risk to global public health and economic security, and are jeopardizing efforts in the control, prevention and elimination of TB globally. Mycob…
Medina
With 5,000 new active cases each year, tuberculosis in Chile remains as the most important communicable disease in the country. Since the type of control programs are linked to the epidemiologic situation as far as infection, morbidity and mortality are concerned, an effective su…
Assefa Hamato Kebede, Hassen Mamo Idris
Abstract Background : Tuberculosis (TB) is one of the oldest diseases known and the spread of drug-resistant TB poses significant challenges in TB control and eradication program globally, and also the distribution varies geographically worldwide and within the countries. Lack of…
Dreyer V, Mandal A, Dev P, Merker M, Barilar I, et al.
Background Multidrug-resistant (MDR) Mycobacterium tuberculosis complex (MTBC) strains are a serious health problem in India, also contributing to one-fourth of the global MDR tuberculosis (TB) burden. About 36% of the MDR MTBC strains are reported fluoroquinolone (FQ) resistant …
David Kajoba Mumena, Geoffrey Kwenda, Caroline Ngugi, Andrew Nyerere
Drug-resistant tuberculosis is a threat to the control of tuberculosis globally, it develops mainly due to mutations in target genes of (MTB). Mutations in the rpoB gene confer resistance to rifampicin (RIF). The most frequent mutations conferring resistance to RIF include; Ser53…