Showing 51–75 of 200 documents
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Zahra Hasan, Sadia Shakoor, Rumina Hasan
…or use [[2]Nicol M.P. Zar H.J. New specimens and laboratory diagnostics for childhood pulmonary TB: progress and prospects.Paediatr Respir Rev. 2011; 12: 16-21Crossref PubMed Scopus (117) Google Scholar,[3]Hasan Z. Shakoor S. Arif F. Mehnaz A. Akber A. Haider M. et al.Evaluation …
Emily MacLean, H. Manisha Yapa
… High priority target product profiles for new tuberculosis diagnostics: report of a consensus meeting.https://www.who.int/publications/i/item/WHO-HTM-TB-2014.18Date: 2014Date accessed: February 12, 2024Google Scholar although signatures performed better than W4SS. All signatures…
Biswajit Chakraborty, Amaj Laskar, Vipin Kumar, Zeeshan M Khan, Remesh Kumar, et al.
…iagnostic accessibility, WHO introduced the first Essential Diagnostics List (EDL) in 2018, providing a global framework for cost-effective and accurate diagnostics for critical diseases, including neglected tropical diseases (NTDs). Building on this, several countries are develo…
Bianca Sossen, Graeme Meintjes
…OHigh-priority target product profiles for new tuberculosis diagnostics: report of a consensus meeting. World Health Organization, Geneva2014Google Scholar There is a clear need for tests that are non-sputum based (eg, urine or blood) in people with HIV, since risk of mortality i…
Nathavitharana RR, Lederer P, Chaplin M, Bjerrum S, Steingart KR, et al.
Background Tuberculosis is the primary cause of hospital admission in people living with HIV, and the likelihood of death in the hospital is unacceptably high. The Alere Determine TB LAM Ag test (AlereLAM) is a point-of-care test and the only lateral flow lipoarabinomannan assay …
Richu Bob Kurien, Priya Nadesan, Balamugesh Thangakunam, Barney Isaac, Thomas Alex Kodiatte, et al.
Abstract Background Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the preferred diagnostic modality for evaluating mediastinal lymphadenopathy. However, its diagnostic yield is significantly reduced in conditions such as sarcoidosis, tuberculosis…
Deo S, Singh S, Jha N, Arinaminpathy N, Dewan P
Background Tuberculosis (TB) incidence in India continues to be high due, in large part, to long delays experienced by patients before successful diagnosis and treatment initiation, especially in the private sector. This diagnostic delay is driven by patients' inclination to swit…
Human Sciences Research Council
In application studies of latent class analysis (LCA) evaluating imperfect diagnostic tests, residual dependence among the diagnostic tests still remain even after conditioning on the true disease status due to measured variables known to affect prevalence and/or alter diagnostic…
Keter AK, Lynen L, Van Heerden A, Goetghebeur E, Jacobs BKM
Background In application studies of latent class analysis (LCA) evaluating imperfect diagnostic tests, residual dependence among the diagnostic tests still remain even after conditioning on the true disease status due to measured variables known to affect prevalence and/or alter…
Andrew D. Kerkhoff, Adithya Cattamanchi, Monde Muyoyeta, Claudia M. Denkinger, David W. Dowdy
Simon Mendelsohn and colleagues (June, 2021)1Mendelsohn SC Fiore-Gartland A Penn-Nicholson A et al.Validation of a host blood transcriptomic biomarker for pulmonary tuberculosis in people living with HIV: a prospective diagnostic and prognostic accuracy study.Lancet Glob Health. …
Elin Folkesson
…nd post-treatment cure. These approaches could transform TB diagnostics, reduce diagnostic delays, and support global TB elimination efforts.</p><h3>List of scientific papers</h3><p dir="ltr">I. A protein signature associated with active tuberculosis ident…
Elin Folkesson
…nd post-treatment cure. These approaches could transform TB diagnostics, reduce diagnostic delays, and support global TB elimination efforts.</p><h3>List of scientific papers</h3><p dir="ltr">I. A protein signature associated with active tuberculosis ident…
Umubyeyi Nyaruhirira A, Scholten JN, Gidado M, Suarez PG
…(COVID-19) undermines control of other infectious diseases. Diagnostics are critical in health care. This opinion paper explores approaches for leveraging diagnostics for COVID-19 while retaining diagnostics for other infectious diseases, including tuberculosis (TB) and HIV. The …
Johsuke Hara, Masaki Fujimura, Masahide Yasui, Reiko Takeda, Noriyuki Ohkura
Abstract Background We previously elucidated the fundamental pathophysiological features of various aetiologies of chronic cough, such as cough variant asthma, atopic cough, and sinobronchial syndrome. We also established a pathophysiological diagnostic procedure for aetiology id…
Caitlin A. Moe, Rita Kabuleta Luswata, Jheannie Barrameda, Hien Le, Seke Muzazu, et al.
ABSTRACT Background Tongue swabs are a promising alternative specimen for tuberculosis (TB) diagnosis, with high specificity (>98%) but lower sensitivity than sputum-based molecular tests. We investigated whether increased sample availability could offset lower sensitivity, re…
Miller AC, Cavanaugh JE, Arakkal AT, Koeneman SH, Polgreen PM
Background The incidence of diagnostic delays is unknown for many diseases and specific healthcare settings. Many existing methods to identify diagnostic delays are resource intensive or difficult to apply to different diseases or settings. Administrative and other real-world dat…
Muhammad Kashif Munir
…attle against Koch’s disease is still being fought and that diagnostics remain the frontline weapon.1 The history of tuberculosis (TB) diagnostics is, in many ways, the history of microbiology itself. From microscopy and culture to molecular assays capable of detecting resistance…
Hongling Wang, Liyan Jiang, Yang Xiao, Linlin Xu, Ning Zhang, et al.
**OBJECTIVES:** Systemic lupus erythematosus (SLE) is a life-threatening autoimmune disorder causing multi-organ damage. Current diagnostic methods are hindered by inadequate sensitivity and specificity of conventional biomarkers, which frequently delay diagnosis. Therefore, iden…
Fahad Nazir, Qiam Ud Din, Zubariah, Saba Afzal Shaikh, Ibrahim, et al.
Objective: To determine the diagnostic accuracy of Mantoux’s test and diagnostic BCG test in the diagnosis of tuberculosis in children by taking AFB (acid fast bacilli) sputum test as gold standard. Study Design: Cross Sectional study. Setting: Imran Idrees Teaching Hospital Sial…
Barkha Vimal, Saurabh Purohit, Albail Singh Yadav
Background: Abdominal tuberculosis (TB) remains a significant diagnostic challenge due to its nonspecific presentation and the limited sensitivity and specificity of conventional diagnostic modalities such as ultrasonography (USG) and contrast-enhanced computed tomography (CECT).…
Anvita Gupta Malhotra, Leena Lokhande, Abhijit Pakhare, Payal Soni, Satya Prakash Vishwakarma, et al.
… These findings advocate for integrating advanced molecular diagnostics into routine tuberculosis workflows to reduce diagnostic delays and improve patient outcomes. **CLINICAL TRAIL NUMBER:** Not applicable.
Broger T, Marx FM, Theron G, Marais BJ, Nicol MP, et al.
…le. Despite the roll-out of molecular WHO-recommended rapid diagnostics to replace sputum smear microscopy over the past decade, a large diagnostic gap remains. Of the estimated 10·6 million people who developed tuberculosis globally in 2022, more than 3·1 million were not diagno…
Raizada N, Khaparde SD, Swaminathan S, Sarin S, Salhotra VS, et al.
…te of the increasing availability of rapid high-sensitivity diagnostics in public and private sectors, majority of paediatric TB cases are empirically diagnosed, without laboratory confirmation. To address these diagnostic challenges, World Health Organization (WHO) has recommend…
Huang JH, Chen H, Zhang ZC, Gu J, Yan L, et al.
Background and objective Cancer ratio (CR), which is defined as serum lactate dehydrogenase (LDH) to pleural fluid adenosine deaminase (ADA) ratio, has been reported to be a useful diagnostic marker for malignant pleural effusion (MPE). Whether its diagnostic accuracy is affected…
Wen Rao, Dafu Wang, Xiaoxue Ma, Jian Zhou, Tingting Gong, et al.
**BACKGROUND:** Rifampicin-resistant tuberculosis (RR-TB) constitutes a persistent and formidable challenge for global TB control programs, as delayed diagnosis and treatment initiation contribute to transmission and poor outcomes. Molecular drug susceptibility testing (mDST) ena…