Showing 51–75 of 200 documents
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Zhang L, Li Y, Zou X, Ma H, Gao M, et al.
…aims to evaluate the diagnostic accuracy of a Mycobacterium tuberculosis (MTB)-specific triple-color FluoroSpot assay (IFN-γ/IL-2/TNF-α) in the differentiation of tuberculosis (TB) infection status in febrile patients. Method Febrile patients with suspected active TB (ATB) were c…
Abebe F, Belay M, Legesse M, K L M C F, Ottenhoff THM
…nvestigate protective and diagnostic immune markers against tuberculosis (TB), we measured antibody isotype responses to Mycobacterium tuberculosis (Mtb) antigens (LAM, Rv2031, and HBHA) in cohorts of 149 pulmonary tuberculosis patients (PTBP), 148 household contacts (HHCs), and …
Pereira AHB, Lopes CAA, Pissinatti TA, Pinto ACA, Oliveira DRA, et al.
… pathology of monkeys naturally infected with Mycobacterium tuberculosis complex from five different colonies in Rio de Janeiro, Brazil. On the basis of gross and histopathological findings, the lesions were classified into chronic-active, extrapulmonary, early-activation or late…
Karaca C, Ozer F, Sevim DG, Erdoğan O, Unlu M
We present a case series of eight patients with ocular tuberculosis (OTB), latent tuberculosis (TB) or sarcoidosis, some of whom were receiving anti-tumor necrosis factor alpha (anti-TNF-α) therapy for various systemic diseases. Only one patient had a positive QuantiFERON®-TB tes…
Jorwal P, Singh BK, Anand A, Khan F, Khandelwal K, et al.
Background Tuberculosis (TB) is still the second causative agent of death worldwide after COVID-19. It is caused by Mycobacterium tuberculosis (MTB) infection. Objective The aim of the current study was to compare the performance of GeneNAT real-time polymerase chain reaction ana…
Teklu T, Wondale B, Taye B, Hailemariam M, Bekele S, et al.
Background Tuberculosis (TB) is one of the world's most problematic infectious diseases. The pathogen Mycobacterium tuberculosis (Mtb) is contained by the immune system in people with latent TB infection (LTBI). No overt disease symptoms occur. The environmental and internal trig…
Dejene TA, Hailu GG, Kahsay AG, Wasihun AG
Introduction Tuberculosis (TB) is the second leading cause of mortality from an infectious disease worldwide. Multidrug-resistant tuberculosis (MDR-TB), where rifampicin-resistant TB is the biggest contributor, remains a global health threat. There is scant data on MTB and rifamp…
Téllez-Navarrete NA, Ramon-Luing LA, Muñoz-Torrico M, Preciado-García M, Medina-Quero K, et al.
Background Tuberculosis (TB) is an infectious disease. During TB, regulatory T cells (Treg) are related to poor prognosis. However, information about conventional and unconventional Treg (cTreg and uTreg, respectively) is limited. The tumour necrosis factor (TNF) and its receptor…
Anuradha Kalotra, Dinesh Kumar, Ravi Kumar, Arvind Kumar Yadav, Kiran Lachala, et al.
Background: Tuberculosis (TB) patients suffer enormously due to huge cost on diagnosis and treatment. This study aims to assess the total expenditure and its predictors among patients of TB. Methodology: A longitudinal study was conducted among TB Patients registered in first qua…
Luo Y, Xue Y, Lin Q, Tang G, Yuan X, et al.
Background Discriminating active tuberculosis (ATB) from latent tuberculosis infection (LTBI) remains challenging. This study aimed to investigate a diagnostic model based on a combination of iron metabolism and the TB-specific antigen/phytohemagglutinin ratio (TBAg/PHA ratio) in…
Goletti D, Delogu G, Matteelli A, Migliori GB
…arter of the global population is infected by Mycobacterium tuberculosis (Mtb). A better control of tuberculosis (TB) is based on the ability to detect Mtb infection, identifying the progressors to TB disease, undergoing to preventive therapy and implementing strategies to regist…
Oudghiri A, Karimi H, Chetioui F, Zakham F, Bourkadi JE, et al.
Background The emergence of extensively drug-resistant tuberculosis (XDR-TB) has raised public health concern for global TB control. Although multi drug-resistant tuberculosis (MDR- TB) prevalence and associated genetic mutations in Morocco are well documented, scarce information…
Arroyo L, Marín D, Franken KLMC, Ottenhoff THM, Barrera LF
Background Tuberculosis (TB) remains one of the most deadly infectious diseases. One-third to one-fourth of the human population is estimated to be infected with Mycobacterium tuberculosis (Mtb) without showing clinical symptoms, a condition called latent TB infection (LTBI). Dia…
Luo Y, Tang G, Lin Q, Mao L, Xue Y, et al.
Objectives Distinguishing between active tuberculosis (ATB) and latent tuberculosis infection (LTBI) remains challenging. Methods The modified T-SPOT.TB assay was performed in 499 participants (243 ATB and 256 LTBI) and another 322 participants (162 ATB and 160 LTBI) who were dia…
Velayutham B, Chadha VK, Singla N, Narang P, Gangadhar Rao V, et al.
…formation on the proportion of new smear-positive pulmonary tuberculosis (PTB) patients treated with a 6-month thrice-weekly regimen under Revised National Tuberculosis Control Programme (RNTCP) who develop recurrent TB after successful treatment outcome. Objective To estimate TB…
Peter M. Mbelele, Emmanuel Mpolya, Elingarami Sauli, Bariki Mtafya, Nyanda Elias Ntinginya, et al.
Abstract Background Rifampin or multidrug-resistant-tuberculosis (RR/MDR-TB) treatment has transitioned to injectable-free regimens. We tested whether M. tuberculosis ( Mtb ) elimination rates measured by molecular bacterial load assay (TB-MBLA) in sputa correlate with compositio…
Benachinmardi K, Sampath S, Rao M
Background : Detection of latent tuberculosis infection (LTBI) in children, exposed to tuberculosis (TB) infections, followed by appropriate treatment, could be instrumental in reducing TB burden. Interferon Gamma release assays (IGRA) have higher specificity than tuberculin skin…
O. A. Zhurilo, A. I. Barbova, P.S. Trophimova, S.V. Mironchenko
…ng the Xpert MTB/XDR method in the algorithm for diagnosing tuberculosis (TB) in Ukraine. Materials and methods. 51 strains of M. tuberculosis (MBT) were studied using Xpert MTB/XDR cartridges, the LPA method and the BASTEC system: 16 MTB strains of the control panel with known r…
S. Saxena, Palak Bhikharbhai Patel, Drushi Patel, Ankur Shah
Patellar tuberculosis (TB) is an uncommon occurrence and has been sparsely reported in the literature. Imaging plays a key role in its diagnosis, as clinical symptoms vary and are often unspecific. We present two cases of isolated patellar tuberculosis, its classical imaging feat…
Sun JM, Wang C, Jin DQ, Deng F
Congenital tuberculosis (TB) is rare and the prognosis is poor if not detected early. The diagnosis is often delayed owing to non-specific clinical presentation, misdiagnosis and undiagnosed maternal TB during pregnancy. A 12-day-old girl presented with a 5-day history of fever, …
Hasto Yuwono
… method and presents an innovative approach for eradicating tuberculosis through the PDCA cycle. The focus is on setting goals for progress and creating strategies to reach them. The research proposes a new innovation, Smantub, combined with technology to decrease TB cases. Findi…
Dashuki AR, Ruzlin ANM, Zamzuri MAIA, Chen XW
Introduction Tuberculosis (TB) is one of the major global health challenges and concerns. Despite the availability of effective treatment in Malaysia, it remained a consistently high notification rate of TB cases. The objective of this study was to determine the proportion of suc…
Scherer J, Mukasa SL, Wolmarans K, Guler R, Kotze T, et al.
Background Tuberculosis (TB) is one of the top ten causes of death worldwide, with approximately 10 million cases annually. Focus has been on pulmonary TB, while extrapulmonary TB (EPTB) has received little attention. Diagnosis of EPTB remains challenging due to the invasive proc…
Sulistijawati RS, Icksan AG, Lolong DB, Nurwidya F
Background Tuberculosis (TB) remains a burden globally, including Indonesia. The primary objective of this study is to reveal the chest radiography characteristic of drug-sensitive TB (DS-TB) and multi-drug resistant TB (MDR-TB) in the Indonesian national tuberculosis prevalence …
Y J Li, Yachun Wang, Lukuan Wei, Wei Wang
… the clinical utility of urinary routine and renal function、Tuberculosis antibody test (TB-DOT) or T-cell spot tests for TB infection(T-SPOT.TB) in blood, either separately or in combination, for the diagnosis of urinary tuberculosis (UTB). Methods Retrospective analysis of urina…