Showing 26–50 of 200 documents
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Lankamo Ena Digesa, Aklil Hailu Beyene, Erdaw Tachbele Betre
…ld>Background:</bold> The emergence of multi-drug resistant tuberculosis (MDR-TB) is a challenge for global prevention and control of the disease. MDR-TB case management is difficult because it exposes to further economic and social costs that the patients face while seeking help…
Kasimu Mamuda, Aliyu Sani, Steven Olonitola, Opaluwa Saraja
Background: Tuberculosis (TB) is one of the leading infectious diseases that cause death worldwide; the emergence of drug resistant mycobacterium tuberculosis is of great concern for TB control programme in Nigeria. Aim and objective: To detect multi-drug and extensively drug res…
Naz S, Farooq U, Ali S, Sarwar R, Khan S, et al.
Multi-drug-resistant tuberculosis and extensively drug-resistant tuberculosis has emerged as global health threat, causing millions of deaths worldwide. Identification of new drug candidates for tuberculosis (TB) by targeting novel and less explored protein targets will be invalu…
Nwachukwu NO, Ulasi AE, Okoronkwo CU, Unegbu VN
Background Pre-extensively drug-resistant tuberculosis (Pre-XDR-TB), an emerging form of drug-resistant tuberculosis, is challenging efforts at tuberculosis control, leading to treatment failure among multidrug-resistant tuberculosis (MDR-TB) patients and progression to extensive…
Hira Ashfaq, Ayesha Humayun, Muhammad Ahmad Naseem, Sarmad Wahaj Siddiqui, Asifa Kamal, et al.
…ROUND:** Globally, the prevalence of drug-resistant (DR-TB) tuberculosis is rising, and Pakistan is currently one of the nations with the highest burden. It is imperative to track changes in the prevalence of DR-TB, particularly the extensively drug-resistant (XDR-TB) tuberculosi…
Li Z, Liu F, Chen H, Han Y, You Y, et al.
…e-extensively drug-resistant plus additional drug-resistant tuberculosis (pre-XDR-plus) in Henan Provincial Chest Hospital between 2017 and 2021. Methods We analysed and summarized the drug sensitivity test (DST) results of clinical Mycobacterium tuberculosis (MTB) strains in TB …
Barilar I, Fernando T, Utpatel C, Abujate C, Madeira CM, et al.
…21, an estimated 4800 people developed rifampicin-resistant tuberculosis in Mozambique, 75% of which went undiagnosed. Detailed molecular data on rifampicin-resistant and multidrug-resistant (MDR) tuberculosis are not available. Here, we aimed at gaining precise data on the deter…
Gizachew Taddesse Akalu, Belay Tessema, Waganeh Sinshaw, Misikir Amare, Getu Diriba, et al.
…ntional wisdom wrongly holds that the microbiological of M. tuberculosis complex in clinical specimens via culture and phenotypic drug susceptibility testing allows people to be correctly diagnosed and ensures an effective treatment regimen to be selected. This study was aimed to…
Yang M, Zhan S, Fu L, Wang Y, Zhang P, et al.
Tuberculosis has become a great global public health threat. Compared with drug-susceptible tuberculosis (TB), the treatment regimens for multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) involve more severe adverse events and poorer t…
Jabbar A, Khan TA, Rehman H, Khan AS, Ahmad S, et al.
Objective To explore the burden of drug-resistant tuberculosis in Khyber Pakhtunkhwa, Pakistan. Methods The cross-sectional study was conducted from March 1, 2016, to February 28, 2017, at the Khyber Pakhtunkhwa Tuberculosis Reference Laboratory, Hayatabad Medical Complex, Peshaw…
Jaglal P, Pillay M, Mlisana K
Background Rapid diagnosis of drug-resistant Mycobacterium tuberculosis is a challenge in low-income countries. Phenotypic drug susceptibility testing using Sensititre ® MycoTB assay and the resazurin microtitre plate assay (REMA) are relatively new innovative methods to determin…
Anjali Yadav, Suman Singh, Rakesh Sharma, Santosh Kumar, Ajay Vir Singh, et al.
…tance and risk factorsfor extensively drug-resistance (XDR)-tuberculosis among multi-drug resistant (MDR)-tuberculosis patients from Agra region of Uttar Pradesh, North India.A total of 279 MDR-Mycobacterium tuberculosis isolates from pulmonary tuberculosis patients of Agra regio…
Mignani S, Tripathi VD, Soam D, Tripathi RP, Das S, et al.
The long-term treatment of tuberculosis (TB) sometimes leads to nonadherence to treatment, resulting in multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis. Inadequate bioavailability of the drug is the main factor for therapeutic failure, which leads to t…
Sheng-Nan Tang, Xi-Ling Huang, Alena Skrahina, Qiu-Ting Zheng, Aleh Tarasau, et al.
…wn to be more prevalent among multidrug-resistant pulmonary tuberculosis (MDR)/extensively drug-resistant tuberculosis (XDR) patients than among drug-sensitive tuberculosis (DS) patients. This study aims to clarify how the interaction betweenaggressiveness and tuberculosis histor…
Xu X, Dong B, Peng L, Gao C, He Z, et al.
Mycobacterium tuberculosis possesses a dynamic cell envelope, which consists of a peptidoglycan layer, a mycolic acid layer, and an arabinogalactan polysaccharide. This envelope possesses a highly complex and unique structure representing a barrier that protects and assists the g…
Saerom Kim, Doosoo Jeon, Taehoon Lee, Seung Jun Lee, Ho Young Lee, et al.
…esistance status and trends in patients with extrapulmonary tuberculosis (EPTB) and compared them with those in patients with pulmonary tuberculosis (PTB). **METHODS:** The phenotypic drug susceptibility test (DST) results of patients with culture-confirmed tuberculosis (TB) dia…
Yenew B, Kebede A, Alemu A, Diriba G, Mehammed Z, et al.
Background The emergence of drug-resistant tuberculosis (DR-TB) has been a major obstacle to global tuberculosis control programs, especially in developing countries, including Ethiopia. This study investigated drug resistance patterns and associated mutations of Mycobacterium tu…
Rollo RF, Mori G, Hill TA, Hillemann D, Niemann S, et al.
…urgent priorities for reducing the immense global burden of tuberculosis (TB). As treatment of TB currently requires multiple antibiotics with diverse mechanisms of action, any new drug lead requires assessment of potential interactions with existing TB antibiotics. We previously…
Chand AB, Basnet A, Maharjan B, Rai G, Joshi YP, et al.
Background Multidrug-resistant tuberculosis (MDR-TB), characterized by isoniazid and rifampicin resistance, is caused by chromosomal mutations that restrict treatment options and complicate tuberculosis management. This study sought to investigate the prevalence of pre-extensivel…
Suphanat Wongsanuphat, Charuttaporn Jitpeera, Orathai Suwanchairob, Wannisa Theprongthong, Patcharin Tantiworrawit, et al.
…DoE) was notified of a confirmed extensively drug-resistant tuberculosis (XDR-TB) case in Bangkok. The DoE and local teams conducted a joint investigation to describe the epidemiological characteristics of the case, identify possible source cases and contacts, and implement contr…
Zhang Z, Cheng Z, Liu Q, Shang T, Jiang L, et al.
…as a Group A agent for the treatment of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) in longer regimens (18-20 months). However, little is known about the safety of LNZ in longer TB treatment regimens in children. Methods Here we …
Hegeto LA, Caleffi-Ferracioli KR, Nakamura-Vasconcelos SS, Almeida AL, Baldin VP, et al.
Tuberculosis (TB) is an important public health problem worldwide and the emergence of multidrug-resistant (MDR) TB and extensively drug-resistant (XDR) TB worsened the global context. The resistance in Mycobacterium tuberculosis, the causative agent of TB, can partially derive f…
Diriba G, Kebede A, Tola HH, Yenew B, Moga S, et al.
Background Molecular characterization of Mycobacterium tuberculosis (MTB) is important to understand the pathogenesis, diagnosis, treatment, and prevention of tuberculosis (TB). However, there is limited information on molecular characteristics and drug-resistant patterns of MTB …
Verma AK, Yadav RN, Kumar G, Dewan RK
Objective This study aimed to analyze the trends of tuberculosis (TB) disease, drugs susceptibility patterns in geriatric TB over a period of three years (from 2010 to 2012). Materials & methods In this study, laboratory data on diagnosis of geriatric tuberculosis suspected patie…
Starshinova A, Dovgalyk I, Belyaeva E, Glushkova A, Osipov N, et al.
… continued growth of multiple- and extensive drug-resistant tuberculosis, use of the new highly effective anti-tuberculosis drugs in this patient category is of great relevance. The aim of the study was determination the efficacy of treatment in patients with multidrug- and exten…