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Juan J. Gómez-Valverde, Ramon Sanchez, José Luis Ribó, H. Simon Schaaf, Lara García Delgado, et al.
<sec> <title>BACKGROUND</title> Tuberculosis (TB) remains a major cause of morbidity and death worldwide, with a significant impact on children, especially those under the age of 5 years. The complex diagnosis of pediatric TB, compounded by limited access to more accurate diagnos…
Mohammed Suleiman, Andrés Pérez-López, Ruwa Mohamed, Faheem Mirza, Amina Souli, et al.
Diagnosing tuberculosis (TB) in children is challenging due to the paucibacillary nature of the disease and difficulty in obtaining sputum samples. This 6-year retrospective study compared the diagnostic performance of the GeneXpert MTB/RIF Ultra PCR (GX-MTB/R-U) assay, an improv…
Christoph Lange, Dumitru Chesov, Olha Konstantynovska, Anna-Maria Mandalakas, Zarir Udwadia
Until the coronavirus disease 2019 pandemic, tuberculosis had been the leading cause of death by an infectious disease worldwide. According to the WHO, there were 1.41 million deaths attributed to tuberculosis in 2019. Globally, the burden of tuberculosis is asymmetrically distri…
Gaensbauer J, Broadhurst R
Purpose of review Tuberculosis is leading cause of global morbidity and mortality and a significant proportion of the burden of disease occurs in children. In the past 5 years, a number of innovations have improved the diagnosis and treatment for children with both latent tubercu…
Agarwal A, Kodethoor D, Khanna A, Hanif M
Background India houses 27% of the tuberculosis cases worldwide. Pediatric tuberculosis accounts for 11% cases worldwide. Microbiological confirmation of diagnosis is difficult in children. We aimed to study the proportion of Stool CBNAAT (Cartridge Based Nucleic Acid Amplificati…
Baucom C, LaPonsie S
Tuberculosis (TB) remains a leading cause of illness and death throughout the world. Despite its high prevalence worldwide, a diagnosis of TB can be hampered by variable clinical presentation, differences in host response, and lack of clinician awareness. In addition to the lungs…
Sobia Rasheed, Salma aziz, Irfan Mehmud, Tanzeela Rani, Nur Ul Ain Umair, et al.
INTRODUCTION: Tuberculosis (TB) is a granulomatous infection caused by Mycobacterium tuberculosis. Pakistan ranks 4th globally. Diagnosis is challenging due to children's inability to expectorate sputum and similar symptoms to other respiratory diseases. Rapid detection is crucia…
Nathella Pavan Kumar, Syed Hissar, Arul Nancy, Kannan Thiruvengadam, Velayuthum V Banurekha, et al.
Diagnosing tuberculosis (TB) in children presents significant challenges, necessitating the identification of reliable biomarkers for accurate diagnosis. In this study, we investigated plasma matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) as …
Sevliya Öcal Demi̇r, Sabriye Gülçin Bozbeyoğlu, Kardelen Çeliker
Objective: Early diagnosis of tuberculosis (TB) is important in reducing morbidity and mortality. In this study, we aimed to determine the signs and symptoms that provide the differential diagnosis of TB in pediatric patients. Patients and Methods: The study included children dia…
Miranda-Schaeubinger M, Venkatakrishna SSB, Otero HJ, Marais BJ, Goussard P, et al.
…ographs (CXR) have played an important and evolving role in diagnosis, classification and management of pediatric pulmonary tuberculosis (TB). During the pre-chemotherapy era, CXR aided in determining infectiousness, mainly to guide isolation practices, by detecting calcified and…
Pooja Shah, Sae Pol, E Prabhakaran, Bhakti Karmalkar, Vaishali Gaikwad, et al.
Abstract Background : Tuberculosis (TB) remains a significant public health challenge in developing countries, including India, where children under 15 years account for 12% of all TB cases. The National Tuberculosis Elimination Programme (NTEP) recommends the use of GeneXpert/Ca…
Kashyap B, Gupta N, Dewan P, Hyanki P, Singh NP
… of disease severity, therapeutic response and prognosis in tuberculosis has been suggested. This study aims to determine the levels of high sensitivity CRP (hs CRP) among the pediatric tuberculosis cases. A case control study was conducted on 60 clinically diagnosed (clinical fi…
Mijović H, Al-Nasser Y, Al-Rawahi GN, Roberts AD
Microbiologic confirmation of pediatric extrapulmonary tuberculosis remains challenging, leading to diagnostic delays. In our retrospective case series, real-time molecular testing (Xpert MTB/RIF) on respiratory and extrapulmonary specimens resulted in a more rapid diagnosis of e…
Lounnas M, Diack A, Nicol MP, Eyangoh S, Wobudeya E, et al.
…atory samples for bacteriological confirmation of childhood tuberculosis but require intensive laboratory processing before molecular testing to remove PCR inhibitors and debris. We aimed to develop a centrifuge-free processing method for use in resource-limited settings based on…
Bhanu Desai, Rushi N Patel, Yashvi Vijaykumar Dattani, Tamannaben Rameshbhai Ninama, Amay Himanshu Khara, et al.
… TB in children. Paediatric clinical feature is variable in tuberculosis. Many cases of primary TB infection in children are asymptomatic and remain completely unnoticed or accidentally discovered at a later stage. In this study we looked for clinical and radiological presentatio…
Sreedeep KS, Sethi S, Yadav R, Vaidya PC, Angurana SK, et al.
…vel molecular diagnostic technique that can be used for the diagnosis of tuberculosis (TB). It is most suited for developing countries as it is rapid, inexpensive, highly sensitive, requiring minimal infrastructure, training and manpower. Studies in pediatric TB are lacking. We e…
Singh UB, Singh M, Sharma S, Mahajan N, Bala K, et al.
…e, and sensitive diagnostic assays are essential for global tuberculosis (TB) control, especially in high TB burden, resource-limited settings. The current study was designed to evaluate diagnostic accuracy of Truenat MTB-Rif Dx (MolBio) in children less than 18 years of age, wit…
Urvashi B. Singh, Manjula Singh, Kiran Bala, Abhinav Srivas, Neeraj Mahajan, et al.
…e, and sensitive diagnostic assays are essential for global tuberculosis (TB) control, especially in high TB burden, resource-limited settings. The current study was designed to evaluate diagnostic accuracy of Truenat MTB-Rif Dx (MolBio) in children less than 18 years of age, wit…
Rina Triasih, Amalia Setyati, Dwikisworo Setyowireni, Titik Nuryastuti, Rachma Dewi Isnaini Putri, et al.
…#x0D; Objective To evaluate the use of Xpert MTB/RIF for TB diagnosis in children.
 Methods We conducted a prospective study in Yogyakarta, Indonesia, involving 19 primary health centers (PHCs) and one provincial hospital. Children aged 0-14 years with suspected TB who visit…
Kay A, Garcia-Prats AJ, Mandalakas AM
…pose of review The detrimental synergy of colliding HIV and tuberculosis (TB) epidemics is most devastating among children and adolescents living with HIV (CALWH) who shoulder a disproportionate burden of all child TB mortality. Recent findings CALWH benefit less from Bacille-Cal…
Ery Olivianto, Agustin Iskandar, Triyana Dian Dhuha Akmaly, Sarah Zoraya Mirza, Maxie Felix Jahono
Background: Tuberculosis (TB) remains a major global health challenge, particularly among children. Diagnosing pediatric TB is complicated due to nonspecific symptoms and the difficulty of obtaining sputum samples for microbiological confirmation. Immunological tests, such as the…
Russo DO, Jimenez ALL, Diniz LMO, Cardoso CA, Romanelli RMC
…ers, delays, and missed opportunities in the prevention and diagnosis of childhood TB. Methods Scoping review according to the PRISMA extension. The definitions considered for the selection followed the acronym PCC where the population (P) is children under 18 years of age with T…
Roxana Mansour Ghanaie, Abdollah Karimi, Leila Azimi, Seddon James, Mahshid Nasehi, et al.
… Although the World Health Organization has recommended the diagnosis and prophylactic treatment of latent tuberculous infection (LTBI) in child household contacts of tuberculosis (TB) cases, the national programs in high-burden TB regions rarely implement adequate screening of t…
Kissling M, Fritschi N, Baumann P, Buettcher M, Bonhoeffer J, et al.
…to-lymphocyte-ratio (MLR) may have diagnostic potential for tuberculosis (TB). Methods Data of two prospective multicenter studies in Switzerland were used, which included children Results Of the 389 children included 25 (6.4%) had TB disease, 12 (3.1%) TB infection, 28 (7.2%) we…
Shruti Kaushal, Sunil Kumar Dhatwalia, Rakesh Yadav, Sumedha Sharma, Pankaj C Vaidya, et al.
…ra), as first-line diagnostic tests for detecting pulmonary tuberculosis (PTB) and rifampicin resistance in children suspected of having the disease. Respiratory specimens (gastric lavage/bronchoalveolar lavage/sputum/endotracheal aspirate) obtained from 116 children with presump…