Showing 1–25 of 200 documents
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Grace AG, Mittal A, Jain S, Tripathy JP, Satyanarayana S, et al.
…eople do not complete this full course. Shortened treatment regimens that are equally effective and safe could improve treatment success. Objectives To evaluate the efficacy and safety of shortened treatment regimens versus the standard six-month treatment regimen for individuals…
Abidi S, Achar J, Assao Neino MM, Bang D, Benedetti A, et al.
…tiveness of two World Health Organization (WHO)-recommended regimens for the treatment of rifampin- or multidrug-resistant (RR/MDR) tuberculosis (TB): a standardised regimen of 9-12 months (the "shorter regimen") and individualised regimens of ≥20 months ("longer regimens").We co…
Park HY, Kwon JW, Kim HL, Kwon SH, Nam JH, et al.
Background Regimens for the treatment of multidrug-resistant tuberculosis (MDR-TB) have been changed from injectable-containing regimens to all-oral regimens. The economic effectiveness of new all-oral regimens compared with conventional injectable-containing regimens was scarcel…
Lin KY, Sun HY, Yang CJ, Lu PL, Lee YT, et al.
…erience with combinations of short-course rifapentine-based regimens and integrase strand-transfer inhibitor-containing antiretroviral therapy (ART) in management of latent tuberculous infection (LTBI) is limited among people with human immunodeficiency virus (PWH). Methods From …
Budak M, Cicchese JM, Maiello P, Borish HJ, White AG, et al.
…ng more effective and more patient-friendly antibiotic drug regimens to increase patient compliance and decrease emergence of resistant TB. Moxifloxacin is one promising antibiotic that may improve the current standard regimen by shortening treatment time. Clinical trials and in …
Hissar S, Velayutham B, Tamizhselvan M, Rathinam S, Arunbabu C, et al.
Background Tuberculosis (TB) lymphadenitis is the most common form of extra-pulmonary TB, and the treatment duration is six months. This non-inferiority based randomized clinical trial in South India evaluated the efficacy and safety of a four-month ofloxacin containing regimen i…
Happiness Cornel Mvungi, Peter Masunga Mbelele, Kassim Salim Msaji, Stellah George Mpagama, Hadija Hamis Semvua
… Health Organization recommended all-oral bedaquiline-based regimens, but evidence comparing their effectiveness to injectable-containing regimens is limited. This study evaluated treatment success between both approaches. **METHODS:** This was a retrospective study, which inclu…
Zainabadi K, Vilbrun SC, Mathurin LD, Walsh KF, Pape JW, et al.
…g-resistant tuberculosis (DR-TB). How these new second-line regimens fare in comparison to first-line regimens for treatment of drug-sensitive tuberculosis (DS-TB) is not well known. Methods In this study, we contemporaneously enrolled subjects with DS-TB (n = 31) or DR-TB (n = 2…
Abangah G, Raughani A, Asadollahi P, Asadollahi K
Aim This study compares the effects of two drug regimens for Helicobacter pylori ( H. pylori ) infection resistant to the first line drug regimen among patients referred to Ilam clinics, Iran. Background Single drug regimen is not effective for H. pylori infection and therefore, …
Ashwin Karnan, Ulhas Jadhav, Babaji Ghewade, Vivek Alone
…reatment. Evaluating the effectiveness of various treatment regimens is crucial for identifying the best balance among treatment duration, efficacy, adverse drug effects, and patient adherence. A prospective, observational study on 50 MDR-TB patients was carried out at a tertiary…
Shah I, Antony S, Jaiswal A, Bodhanwala M, Shah D, et al.
Introduction The prevalence of multidrug resistant (MDR) tuberculosis (TB) with additional resistance to fluoroquinolones or second-line injectables (MDRFQ/SLI)/extensively drug-resistant TB (XDR-TB) in children is high in Mumbai. There are limited therapeutic options available i…
Ji L, Yang W, Gao LJ, Zhang BY, Xu YQ, et al.
…ts often cannot tolerate traditional intensive chemotherapy regimens, and finding the optimal timing in the treatment of both AML and active pulmonary TB is complex. Neglecting timely treatment can lead to serious complications and even fatal outcomes. The present paper reports t…
Ghosh R, Roy S, Rashid MK
Purpose The Revised National Tuberculosis Control Programme (RNTCP) is now introducing daily fixed-dose regimen instead of Directly Observed Treatment, Short Course (DOTS) regimen for treatment of drug-sensitive tuberculosis (TB) in India. It would be beneficial to understand the…
Jefman Efendi Marzuki HY, Nafrialdi N, Sawitri N, Sugiri YJ, Gusti Agung Ayu Putu Sri Darmayani I, et al.
…DR-TB patients on DLM regimen compared to shorter treatment regimens (STR). Methods A retrospective cohort was implemented on secondary data obtained from two participating hospitals. The QTc interval and the changes in QTc interval from baseline (ΔQTc) were assessed every 4 week…
Inbaraj LR, Manesh A, Ponnuraja C, Bhaskar A, Srinivasalu VA, et al.
… up for 1 year after the treatment. DISCUSSION: Current WHO regimens have agents with poor central nervous system drug exposure and is too long. It does not reflect the accumulating evidence in the field. We propose a comprehensive clinical trial incorporating the emerging eviden…
Sacks HS
Source citation Paton NI, Cousins C, Suresh C, et al; TRUNCATE-TB Trial Team. Treatment strategy for rifampin-susceptible tuberculosis. N Engl J Med. 2023;388:873-887. 36808186.
Rosu L, Madan JJ, Tomeny EM, Muniyandi M, Nidoi J, et al.
…he STREAM stage 2 trial assessed two bedaquiline-containing regimens for rifampicin-resistant tuberculosis: a 9-month all-oral regimen and a 6-month regimen containing an injectable drug for the first 2 months. We did a within-trial economic evaluation of these regimens. Methods …
Clemens DL, Lee BY, Silva A, Dillon BJ, Masleša-Galić S, et al.
…ile many TB drugs are available, identification of the best regimens is challenging because of the large number of possible drug-dose combinations. We have found consistently that responses of cells or whole animals to drug-dose stimulations fit a parabolic response surface (PRS)…
Goodall RL, Nunn AJ, Meredith SK, Bayissa A, Bhatnagar AK, et al.
…round STREAM stage 2 showed that two bedaquiline-containing regimens (a 9-month all-oral regimen and a 6-month regimen with 8 weeks of aminoglycoside) had superior efficacy to a 9-month injectable-containing regimen for rifampicin-resistant tuberculosis up to 76 weeks after rando…
Gu P, Lu P, Ding H, Liu Q, Ding X, et al.
…ound To compare the effectiveness, cost, and safety of four regimens recommended by the World Health Organization (WHO) for rifampicin resistance/multidrug-resistance tuberculosis (RR/MDR-TB) Treatment in Eastern China. Methods We performed a cohort study among patients with RR/M…
Ryckman TS, McQuaid CF, Cohen T, Menzies NA, Kendall EA
…of separate rifampicin-susceptible and rifampicin-resistant regimens. We estimated incremental cures; averted deaths, secondary cases, and costs; and prices below which a pan-tuberculosis regimen would be cost saving. We also assessed scenarios intended to describe which mechanis…
Danyuchen Sun, Zhili Li, Yingpeng Qiu, Wei Shu, Lijie Zhang, et al.
…valuate the cost-effectiveness of two novel drug containing regimens compared to traditional regimen in Chinese adult population. **METHODS:** We performed a cost-effectiveness analysis from the perspective of the patient. Clinical treatment information and outcomes were retrosp…
Sisay M, Edessa D, Ayele Y, Getachew M
…pattern of and reasons for change of antiretroviral therapy regimens among HIV/AIDS patients at Jugel Hospital, Eastern Ethiopia. Methods A retrospective cross-sectional study was conducted to review medical records of 220 patients who had been on treatment and experienced regime…
Nsengiyumva NP, Campbell JR, Oxlade O, Vesga JF, Lienhardt C, et al.
…r, and cheaper tuberculosis (TB) preventive treatment (TPT) regimens will enhance uptake and effectiveness. WHO developed target product profiles describing minimum requirements and optimal targets for key attributes of novel TPT regimens. We performed a cost-effectiveness analys…
Ding Y, Zhu H, Fu L, Zhang W, Wang B, et al.
…after 8 weeks). In conclusion, oral short-course three-drug regimens, including TBI-166 with high efficacy, were identified. The TBI-166+BDQ+PZA regimen is recommended for further study in a TBI-166 phase IIb clinical trial.