Showing 151–175 of 200 documents
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Tornheim JA, Madugundu AK, Paradkar M, Fukutani KF, Queiroz ATL, et al.
…kground Gene expression profiling is emerging as a tool for tuberculosis diagnosis and treatment response monitoring, but limited data specific to Indian children and incident tuberculosis infection (TBI) exist. Methods Sixteen pediatric Indian tuberculosis cases were age- and se…
Berihun YA, Nguse TM, Gebretekle GB
Background Prevalence of tuberculosis in vulnerable groups such as prisoners is usually high, and the problem is worsened by poor treatment outcomes. In spite of this, there is limited information regarding tuberculosis in prisons of Ethiopia. Hence, this study was aimed to asses…
Burke RM, Nliwasa M, Dodd PJ, Feasey HRA, Khundi M, et al.
Background Tuberculosis case-finding interventions are critical to meeting World Health Organization End TB strategy goals. We investigated the impact of community-wide tuberculosis active case finding (ACF) alongside scale-up of human immunodeficiency virus (HIV) testing and car…
Martini M, Gazzaniga V, Behzadifar M, Bragazzi NL, Barberis I
… the most frequently prescribed remedy for the treatment of tuberculosis was a stay in a temperate climate. From the middle of the 19th century to the middle of the 20th, Europe saw the development of sanatoria, where patients were able to benefit from outdoor walks, physical exe…
Gezahegn LK, Argaw E, Assefa B, Geberesilassie A, Hagazi M
…amide has proved to be highly effective in the treatment of tuberculosis (TB). However, the most common adverse effect of this regimen leading to interruption of therapy is hepatotoxicity. There is a paucity of evidence in Tigray region on anti-tuberculosis drug-induced hepatitis…
Noubiap JJ, Nansseu JR, Nyaga UF, Nkeck JR, Endomba FT, et al.
…d poor glycaemic control significantly increase the risk of tuberculosis and adversely affect tuberculosis treatment outcomes, the global burden of diabetes in the context of tuberculosis remains unknown. We did a systematic review and meta-analysis to estimate the prevalence of …
López-González JA, Martínez-Soto JM, Avila-Cervantes C, Mata-Pineda AL, Álvarez-Hernández G, et al.
…s mellitus (DM) is a common comorbidity of active pulmonary tuberculosis (APTB) that increases the risk of treatment failure during anti-tuberculosis chemotherapy. Evaluating systemic inflammatory response could help determine differences in response to treatment between APTB pat…
Jiang G, Qin W, Du X, Zhang Y, Zhang M, et al.
Background Anti-tuberculosis drug concentrations are critical for the treatment of spinal tuberculosis. The distribution pattern of anti-tuberculosis drugs between the blood and the vertebral focus needs to be further explored. Methods A total of 31 spinal tuberculosis patients w…
Owusu DO, Adankwah E, Aniagyei W, Acheampong I, Minadzi D, et al.
… after birth in several countries with a high prevalence of tuberculosis, including Ghana. Previous studies showed that BCG vaccination prevents individuals from developing severe clinical manifestations of tuberculosis, but BCG vaccination effects on the induction of IFN-γ after…
Araya S, Negesso AE, Tamir Z
Background Drug-resistant tuberculosis remains a major public health threat complicating tuberculosis control programs globally. Data on rifampicin resistance (RR), which is a surrogate marker for multidrug resistance, are limited among Ethiopian tuberculosis patients. This study…
Kentaro Kasuga, Miyako Kitazono, Masaomi Maeda, Taro Koba, Shuichi Matsuda, et al.
Female genital tuberculosis is a rare and often asymptomatic condition, which makes its diagnosis challenging. Early recognition of uncommon clinical presentation of tuberculosis is crucial for the better management of it. We report herein a case of genital tuberculosis that init…
Musiimenta A, Tumuhimbise W, Atukunda E, Mugaba A, Linnemayr S, et al.
…ies (DATs), such as real-time monitors and SMS reminders in tuberculosis medication adherence, suboptimal patient engagement with various DATs has been reported. Additionally, financial constraints can limit DAT's utility. The perceived usefulness and the design mechanisms of DAT…
Wu X, Yang J, Tan G, Liu H, Liu Y, et al.
…tigate the drug resistance characteristics of Mycobacterium tuberculosis (MTB) isolates from patients with tuberculosis to 12 antituberculous drugs in China. Methods: All clinical isolates of MTB were isolated from patients with tuberculosis in Shanghai Pulmonary Hospital (SPH) d…
Umayorubhagom A, Baliga SS
Background Tuberculosis disease epidemiology is closely related to social and economic conditions which make its prevention, control and cure challenging. Early diagnosis and adequate treatment will help to prevent various tuberculosis related morbidities. Factors such as adverse…
Tarekegn BG, Tientcheu LD, Decker J, Bell AJ, Mukamolova GV, et al.
Background High proportions of Mycobacterium tuberculosis cells in sputum containing triacylglycerol-rich lipid bodies have been shown to be associated with treatment failure or relapse following antituberculous chemotherapy. Although lipid body determination is a potential bioma…
Adankwah E, Nausch N, Minadzi D, Abass MK, Franken KLMC, et al.
…ase assays (IGRAs) used for diagnosis of Mycobacterium (M.) tuberculosis infection have limited sensitivity. Alternative cytokines and M. tuberculosis latency-associated antigens may improve immune-based tests. Methods Multiplex cytokine analyses was done in culture supernatants …
Boloko L, Schutz C, Sibiya N, Balfour A, Ward A, et al.
Background Mycobacterium tuberculosis bloodstream infection is a leading cause of death in people living with HIV and disseminated bacillary load might be a key driver of disease severity. We aimed to assess Xpert MTB/RIF Ultra (Xpert Ultra) testing of blood as a diagnostic for M…
Tembo BP, Malangu NG
…iated with the prevalence of multidrug/rifampicin-resistant tuberculosis among suspected drug resistant tuberculosis patients in Botswana. Methods A retrospective review of medical records of suspected drug resistant tuberculosis patients receiving care at public health facilitie…
Musisi E, Wamutu S, Ssengooba W, Kasiinga S, Sessolo A, et al.
Background In 2018, the tuberculosis molecular bacterial load assay (TB-MBLA), a ribosomal RNA-based test, was acknowledged by WHO as a molecular assay that could replace smear microscopy and culture for monitoring tuberculosis treatment response. In this study, we evaluated the …
Abhishek S, Ryndak MB, Choudhary A, Sharma S, Gupta A, et al.
Background Studies on human intraocular tuberculosis (IOTB) are extremely challenging. For understanding the pathogenesis of IOTB, it is important to investigate the mycobacterial transcriptional changes in ocular environment. Methods Mice were challenged intravenously with Mycob…
Muflihah H, Flórido M, Lin LCW, Xia Y, Triccas JA, et al.
…t protection against pulmonary infection with Mycobacterium tuberculosis. Immunity induced by subcutaneous immunization with BCG wanes and does not promote early recruitment of T cell to the lungs after M. tuberculosis infection. Delivery of Tuberculosis (TB) vaccines to the lung…
Ronge L, Sloot R, Du Preez K, Kay AW, Kirchner HL, et al.
…ween quantitative IFNγ response and degree of Mycobacterium tuberculosis exposure, infection and tuberculosis (TB) disease status in children. Methods We completed cross-sectional analysis of children (≤15 years) exposed to an adult with bacteriologically confirmed TB, 2007-2012 …
Li X, Sheng L, Tu J, Lou L
…o determine the bactericidal effect of nano silver and anti-tuberculosis drugs on drug-resistant Mycobacterium tuberculosis . Solid-state drug sensitivity tests with streptomycin (SM), isoniazid (INH), RIF, EMB, kanamycin (km), and ofloxacin (ofx) were carried out on H37Rv and di…
Chu AL, Lecca LW, Calderón RI, Contreras CC, Yataco RM, et al.
…hown that cigarette smoking increases the infectiousness of tuberculosis patients, the impact of smoking cessation on tuberculosis transmissibility has not been evaluated. Methods Between 2009 and 2012, we enrolled 4500 tuberculosis patients and followed 14 044 household contacts…
Rakotomanana F, Dreyfus A, Randrianarisoa MM, Raberahona M, Chevallier E, et al.
The incidence rate of tuberculosis in prisons is estimated to be 8 times greater than that in the general population in Madagascar. Our objectives were to estimate the prevalence of pulmonary tuberculosis and HIV infection among prisoners and to identify risk factors associated w…