Showing 76–100 of 200 documents
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Hu SS, Wei QC, Wu Y, Li XN, Liu FJ, et al.
Background Extrapulmonary tuberculosis (TB) is a relatively rare form of tuberculosis infection, accounting for approximately 15% of all tuberculosis infections. Lymph nodes are the most commonly affected sites, while involvement of the parotid gland is extremely rare. Case prese…
Engel N, Ochodo EA, Karanja PW, Schmidt BM, Janssen R, et al.
…kground Programmes that introduce rapid molecular tests for tuberculosis and tuberculosis drug resistance aim to bring tests closer to the community, and thereby cut delay in diagnosis, ensure early treatment, and improve health outcomes, as well as overcome problems with poor la…
Oo MM, Tassanakijpanich N, Phyu MH, Safira N, Kandel S, et al.
Background The comorbid presence of tuberculosis and diabetes mellitus has become an increasingly important public health threat to the prevention and control of both diseases. Thus, household contact investigation may serve a dual purpose of screening for both tuberculosis and d…
Gebremariam G, Kiros M, Hagos S, Hadush H, Gebremichael A, et al.
Background Tuberculosis (TB) is a major public health concern in the developing countries. Moreover, the emergence of multidrug-resistant tuberculosis is challenging. However, there are no organized data on the trends of pulmonary tuberculosis and rifampicin-resistant Mycobacteri…
Ali MM, Weldegebreal F, Kabew G, Urgesa K
Background Multi-drug resistant Mycobacterium tuberculosis is a growing public health problem in developing countries including Somalia. Although, the prevalence of multi-drug resistant tuberculosis among new and retreated cases is high, data on GeneXpert- Mycobacterium tuberculo…
Belay M, Tulu B, Younis S, Jolliffe DA, Tayachew D, et al.
…rface marker have been posited as a niche for Mycobacterium tuberculosis complex bacilli during latent tuberculosis infection. Our aim was to determine whether M tuberculosis complex DNA is detectable in CD34-positive peripheral blood mononuclear cells (PBMCs) isolated from asymp…
Alrajhi AA, Alotaibi J, Alghamdi AM, Almanea H, AlSebayel M, et al.
Objectives Mycobacterium tuberculosis DNA has been detected in multiple organs in people without active tuberculosis or a history of tuberculosis. Molecular testing for metabolic activity has suggested that M tuberculosis DNA represents viable bacilli. Whether transplanted organs…
Onah CK, Azuogu BN, Ossai EN, Agu AP, Azuogu VC, et al.
Background A major constraint to tuberculosis control is low case finding with under-reporting to national authorities. Evidence shows that Patent Medicine Dealers are first port of call for most people with symptoms of tuberculosis, yet there is poor referral of such clients to …
Chen J, Xu Z, Xu H, Bai L
Objectives Reducing mortality during anti-tuberculosis treatment is crucial for completing full-course standardized therapy and achieving tuberculosis cure. The study aims to analyze the mortality and its influencing factors among pulmonary tuberculosis patients undergoing anti-t…
Hao X, Bai J, Ding Y, Wang J, Liu Y, et al.
…ty of traditional etiological methods to diagnose pulmonary tuberculosis rapidly and effectively, the antibody responses against 38kD and 16kD-antigens of Mycobacterium tuberculosis ( M. tuberculosis ) were both detected in order to obtain a better serological detection method fo…
Yang C, Yasseen AS 3rd, Stimec J, Rea E, Waters V, et al.
…ground There are few data about the utility of the Canadian tuberculosis medical surveillance system for detecting tuberculosis in children and adolescents. We sought to assess the prevalence of tuberculosis infection and disease in children and adolescents referred by the tuberc…
Menzies NA, Swartwood NA, Cohen T, Marks SM, Maloney SA, et al.
Background For settings with low tuberculosis incidence, disease elimination is a long-term goal. We investigated pathways to tuberculosis pre-elimination (incidence Methods Using a mathematical modelling framework, we simulated how US tuberculosis incidence could be affected by …
Gemechu Gelana Ararame, Birbirsa Sefera Senbeta, Tesfaye Negesa Liche, Elias Zewdu Sileshi
Comorbid diseases are complex diseases associated with tuberculosis that may affect tuberculosis treatment outcomes and mortality. The impact of comorbid diseases on tuberculosis treatment outcomes and mortality is not well known in Ethiopia. To assess the impact of comorbid dise…
Vyawahare C, Mukhida S, Khan S, Gandham NR, Kannuri S, et al.
Introduction Tuberculosis remains a global health problem worldwide and the risk progression of Tuberculosis to Drug Resistant Tuberculosis is influenced by various factors. These include immunocompromised status, past history of tuberculosis, life style and nutritional level. He…
Meier NR, Sutter TM, Jacobsen M, Ottenhoff THM, Vogt JE, et al.
Rationale Tuberculosis diagnosis in children remains challenging. Microbiological confirmation of tuberculosis disease is often lacking, and standard immunodiagnostic including the tuberculin skin test and interferon- γ release assay for tuberculosis infection has limited sensiti…
Chiang SS, Murray MB, Kay AW, Dodd PJ
Introduction During adolescence, tuberculosis incidence rises, with a greater increase in males compared with females. Tuberculosis notifications and estimates infrequently disaggregate adolescent age groups. Moreover, the factors that drive the increases in overall incidence and…
Silva S, Arinaminpathy N, Atun R, Goosby E, Reid M
Background The tuberculosis targets for the UN Sustainable Development Goals (SDGs) call for a 90% reduction in tuberculosis deaths by 2030, compared with 2015, but meeting this target now seems highly improbable. To assess the economic impact of not meeting the target until 2045…
Pinto PFPS, Teixeira CSS, Ichihara MY, Rasella D, Nery JS, et al.
Background Although household contacts of patients with tuberculosis are known to be particularly vulnerable to tuberculosis, the published evidence focused on this group at high risk within the low-income and middle-income country context remains sparse. Using nationwide data fr…
Reichler MR, Khan A, Sterling TR, Zhao H, Moran J, et al.
Background The risk and timing of tuberculosis among recently exposed close contacts of patients with infectious tuberculosis are not well established. Methods We prospectively enrolled patients ≥15 years of age with culture-confirmed pulmonary tuberculosis and their close contac…
Daniel W, Tadesse S, Tamirat T, Selamu M
Background The risk of tuberculosis transmission is higher among household contacts than the general population. However, there is a paucity of information that explains the risk of experiencing active tuberculosis among household contacts in countries with a high burden of tuber…
Jia Q, Masleša-Galić S, Nava S, Horwitz MA
Mycobacterium tuberculosis infects approximately one-third of the world's population, causing active tuberculosis (TB) in ~10 million people and death in ~1.5 million people annually. A potent vaccine is needed to boost the level of immunity conferred by the current Mycobacterium…
Bi D, Liang C, Huang X, Pan H, Qin Y, et al.
…ility of commercially available antibodies of Mycobacterium tuberculosis in the diagnostic assessment of suspected tuberculosis in high-burden countries. Methods We conducted a retrospective, descriptive, cohort study among participants aged ≥ 18 years with suspected tuberculosis…
Saha A, Escuduero J, Layouni T, Richardson B, Hou S, et al.
…ound Pregnancy is a risk factor for progression from latent tuberculosis infection to symptomatic tuberculosis. However, how pregnancy influences T-cell responses to Mycobacterium tuberculosis is unknown. Methods We measured M. tuberculosis-specific cytokines, T-cell memory marke…
Pelzer PT, Stuck L, Martinez L, Richards AS, Acuña-Villaorduña C, et al.
Background Tuberculosis vaccine trials using disease as the primary endpoint are large, time consuming, and expensive. An earlier immunological measure of the protection against disease would accelerate tuberculosis vaccine development. We aimed to assess whether the effectivenes…
Meiwes L, Kontsevaya I, Chesov D, Kulciţkaia S, Dreyer V, et al.
…ce mask sampling (FMS) confirmed detection of Mycobacterium tuberculosis DNA from exhaled breath in adults with tuberculosis. To date, no study has evaluated the use of FMS to detect pulmonary tuberculosis in children. We developed a method for FMS of M. tuberculosis-specific DNA…