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Katherine Gass
…. For neglected tropical diseases (NTDs), the need for good diagnostics is nothing new, but has grown increasingly acute in recent years. While today’s diagnostic tools have been sufficient for endemicity mapping and monitoring the progress of mass drug administration (MDA), they…
Aggrey Keya, Pauline Gitonga, Daniel Wanjohi, Esther Lemarkoko, Joseph Sankok, et al.
…the disease is endemic. Reliable and accurate point-of-care diagnostics are essential for timely case identification and effective disease management. The Febrile Brucella Agglutination Test (FBAT) is commonly used for diagnosis of brucellosis in Kenya, but concerns have been not…
Ketut Suryana, Hamong Suharsono, Ida Bagus Ngurah
Objectives: The objectives of the study were to evaluate the diagnostic value of conventional tuberculosis (TB) diagnostic procedure compared with Gene X-pert Mycobacterium tuberculosis/rifampicin (MTB/RIF). 
 Methods: A cross-sectional study conducted from January to Decemb…
Human Sciences Research Council
Diagnostic accuracy studies in pulmonary tuberculosis (PTB) are complicated by the lack of a perfect reference standard. This limitation can be handled using latent class analysis (LCA), assuming independence between diagnostic test results conditional on the true unobserved PTB …
Bo Liang, Siyuan Yang, Xingang Zhou, Xinghuan Ding, Jianbo Wang, et al.
<title>Abstract</title> <bold>Background</bold>: The diagnosis of brain tuberculoma (BT) is sometimes challenging. Herein, we presented a case series to evaluate the combined-diagnostic methods, including acid-fast bacilli (AFB) stain, polymerase chain reaction (PCR), Gene Xpert …
Onya Opota, René Brouillet, Gilbert Greub, Katia Jaton
OBJECTIVES: In order to cope with the rapid spread of the COVID-19 pandemic, we introduced on our in-house high-throughput molecular diagnostic platform (MDx Platform) a real-time reverse transcriptase PCR (RT-PCR) to detect the SARS-CoV-2 from any clinical specimens. The aim of …
Udalamaththa Gamage Gihan Chamind, Krishantha Wickramasekara Rajapaksha Wimalagunarathne, H.L.S. Chathurika M.C. Mudannayake, Sunil De Alwis
Tuberculosis (TB) is prevalent in Sri Lanka and poses a considerable public health issue, even though the country is categorized as having a low burden of the disease.It ranks as the second most significant infectious disease in Sri Lanka, with around 500 to 600 fatalities each y…
Ahmadul Hasan Khan, Shakila Yeasmin, Sanjida Anjum, F Haque
Abstract Background Provision of early and accurate Tuberculosis (TB) diagnosis is crucial to end TB specially in a densely populated like Bangladesh. Molecular WHO-approved rapid diagnostic tests for TB (mWRDs) can significantly improve identification of undiagnosed TB cases. Th…
Jin Ma, Lu Qi, Shan Tung Tu, Xiaoyan Miao, Juan Zhao
Background: Respiratory tract infection (RTI) is one of the most common diseases worldwide, and its incidence is rising year by year due to environmental pollution. Sputum culture remains the gold standard for RTI diagnosis, but its performance is limited by difficulties related …
Himanshu Jha, Chandra Prakash Baveja, Vinay Kamal, Prem Narayan Agarwal, Sonal Saxena, et al.
Background and Objectives . Tuberculosis has become a major health problem in India, and the incidence of tuberculous lymphadenitis (TBLN) has increased in parallel with the increase in the incidence of mycobacterial infection worldwide. Therefore, the main objective of this stud…
Daniel Mukadi‐Bamuleka, Junior Bulabula-Penge, Bart K. M. Jacobs, Anja De Weggheleire, François Edidi-Atani, et al.
BACKGROUND: Ebola virus disease (EVD) outbreaks have emerged in Central and West Africa. EVD diagnosis relies principally on RT-PCR testing with GeneXpert®, which has logistical and cost restrictions at the peripheral level of the health system. Rapid diagnostic tests (RDTs) woul…
Luana Michelly Aparecida da Costa, Filipe Andrade Bernardi, Tiago Lara Michelin Sanches, Afrânio Lineu Kritski, Rafael Mello Galliez, et al.
…ee sharply the whole flow of processes in order to evaluate diagnostics cascades. Based on that, first, we developed a design of tuberculosis system operations in discrete-time based model, then we made a description of an agent-based transmission model developed to be incorporat…
Kehongo Moses Nyanguru, Ephantus G. Ndirangu, Robi Chacha, Bakari Chaka, J. O. Moody, et al.
Background: Tuberculosis (TB) remains a significant global health burden, exacerbated by increasing multidrug resistance. Medicinal plants, such as Albizia zygia (DC.) J.F. Macbr, is being used in Kenya to manage TB symptoms; however, antimycobacterial potential remains scientifi…
David Branigan, Claudia M. Denkinger, Jennifer Furin, Petra Heitkamp, Stijn Deborggraeve, et al.
… and link more people to testing with WHO-recommended rapid diagnostics.7Stop TB PartnershipThe introducing new tools project.https://www.stoptb.org/accelerate-tb-innovations/introducing-new-tools-projectDate accessed: May 16, 2023Google Scholar, 8Marks GB Horsburgh Jr, CR Fox GJ…
Zahra Hasan, Sadia Shakoor, Rumina Hasan
…or use [[2]Nicol M.P. Zar H.J. New specimens and laboratory diagnostics for childhood pulmonary TB: progress and prospects.Paediatr Respir Rev. 2011; 12: 16-21Crossref PubMed Scopus (117) Google Scholar,[3]Hasan Z. Shakoor S. Arif F. Mehnaz A. Akber A. Haider M. et al.Evaluation …
Emily MacLean, H. Manisha Yapa
… High priority target product profiles for new tuberculosis diagnostics: report of a consensus meeting.https://www.who.int/publications/i/item/WHO-HTM-TB-2014.18Date: 2014Date accessed: February 12, 2024Google Scholar although signatures performed better than W4SS. All signatures…
Biswajit Chakraborty, Amaj Laskar, Vipin Kumar, Zeeshan M Khan, Remesh Kumar, et al.
…iagnostic accessibility, WHO introduced the first Essential Diagnostics List (EDL) in 2018, providing a global framework for cost-effective and accurate diagnostics for critical diseases, including neglected tropical diseases (NTDs). Building on this, several countries are develo…
Bianca Sossen, Graeme Meintjes
…OHigh-priority target product profiles for new tuberculosis diagnostics: report of a consensus meeting. World Health Organization, Geneva2014Google Scholar There is a clear need for tests that are non-sputum based (eg, urine or blood) in people with HIV, since risk of mortality i…
Richu Bob Kurien, Priya Nadesan, Balamugesh Thangakunam, Barney Isaac, Thomas Alex Kodiatte, et al.
Abstract Background Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the preferred diagnostic modality for evaluating mediastinal lymphadenopathy. However, its diagnostic yield is significantly reduced in conditions such as sarcoidosis, tuberculosis…
Human Sciences Research Council
In application studies of latent class analysis (LCA) evaluating imperfect diagnostic tests, residual dependence among the diagnostic tests still remain even after conditioning on the true disease status due to measured variables known to affect prevalence and/or alter diagnostic…
Andrew D. Kerkhoff, Adithya Cattamanchi, Monde Muyoyeta, Claudia M. Denkinger, David W. Dowdy
Simon Mendelsohn and colleagues (June, 2021)1Mendelsohn SC Fiore-Gartland A Penn-Nicholson A et al.Validation of a host blood transcriptomic biomarker for pulmonary tuberculosis in people living with HIV: a prospective diagnostic and prognostic accuracy study.Lancet Glob Health. …
Elin Folkesson
…nd post-treatment cure. These approaches could transform TB diagnostics, reduce diagnostic delays, and support global TB elimination efforts.</p><h3>List of scientific papers</h3><p dir="ltr">I. A protein signature associated with active tuberculosis ident…
Elin Folkesson
…nd post-treatment cure. These approaches could transform TB diagnostics, reduce diagnostic delays, and support global TB elimination efforts.</p><h3>List of scientific papers</h3><p dir="ltr">I. A protein signature associated with active tuberculosis ident…
Johsuke Hara, Masaki Fujimura, Masahide Yasui, Reiko Takeda, Noriyuki Ohkura
Abstract Background We previously elucidated the fundamental pathophysiological features of various aetiologies of chronic cough, such as cough variant asthma, atopic cough, and sinobronchial syndrome. We also established a pathophysiological diagnostic procedure for aetiology id…
Caitlin A. Moe, Rita Kabuleta Luswata, Jheannie Barrameda, Hien Le, Seke Muzazu, et al.
ABSTRACT Background Tongue swabs are a promising alternative specimen for tuberculosis (TB) diagnosis, with high specificity (>98%) but lower sensitivity than sputum-based molecular tests. We investigated whether increased sample availability could offset lower sensitivity, re…