Showing 1–25 of 200 documents
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Niaina RAKOTOSAMIMANANA, PhD
…ributor to maternal mortality in high-burden regions, TB in pregnancy is a hugely neglected area of global public health. During pregnancy, the symptoms of TB are often overlooked and undiagnosed because they are vague, non-specific, and can be very similar to common complaints d…
Ekaterina V Kurbatova, William C Whitworth, Kia E Bryant, Meredith G Dixon, Kelly E Dooley, et al.
…) treatment compared with the standard regimen. We analyzed pregnancy outcomes of women who became pregnant during the study. Among 740 women, 97 (13.1%) became pregnant. Of 102 pregnancies (in 97 participants), 30 (29.4%) participants were exposed to study drugs. Fetal loss…
Mark Mirochnick, MD
… (ARV) and anti-tuberculosis (TB) drugs administered during pregnancy and postpartum. This study will evaluate the pharmacokinetic (PK) properties of antiretroviral (ARV) and anti-tuberculosis (TB) drugs administered during pregnancy and postpartum. IMPAACT 2026 is a Phase IV o…
Grace Montepiedra, Lisa Aaron, Gerhard Theron, Katie McCarthy, Sarah Bradford, et al.
…eeks of isoniazid preventive therapy (IPT) initiated during pregnancy (immediate IPT) versus deferring to week 12 postpartum (deferred IPT) in people with HIV on antiretroviral therapy, showed higher than expected hepatotoxicity. We investigated the potential roles of antiretrovi…
Richard Chaisson, MD
Pregnant women who develop active Tuberculosis (TB) are at increased risk of poor maternal and infant outcomes. Our data from South Africa show that up to 3% of HIV-infected pregnant women have active TB , many with advanced disease, contributing to the 40% of maternal mortality …
Rosie Mngqibisa, MBChB, MPH, Susan E. Cohn, MD, MPH, Jennifer Robinson, MD, MPH
…e. In the setting of the treatment of active TB, preventing pregnancy becomes even more important because it allows women to attain a level of health that will support healthy future pregnancies. Treatment options for TB may be limited in pregnancy because of concerns about terat…
Helen McShane, MD and PhD
…y and only those who undertake to take precautions to avoid pregnancy during the study period will be eligible. Volunteers will give signed consent for their GP's to be notified about their participation in the trial. The GP will be faxed a letter on the day of screening and aske…
Helen McShane, MD and PhD
…y and only those who undertake to take precautions to avoid pregnancy during the study period will be eligible. Volunteers will give signed consent for their GP's to be notified about their participation in the trial. The GP will be faxed a letter on the day of screening and aske…
Helen McShane, MD and PhD
…y and only those who undertake to take precautions to avoid pregnancy during the study period will be eligible. Volunteers will give signed consent for their GP's to be notified about their participation in the trial. The GP will be faxed a letter on the day of screening and aske…
Adrian Martineau, Prof
…. All women of childbearing age will be asked to do a urine pregnancy test before the PET-CT scan ; the scan will not proceed unless a negative pregnancy test result is obtained at this time. Blood samples (volume of 19 ml) for immunological testing and an induced sputum sample w…
Shuihua Lu, Bachelor, Hai Huang, Bachelor, Guan Liu, Master
…is culture, tuberculosis smear, HIV antibody test and blood pregnancy（only women of childbearing age） during the screening period.Vital signs were checked before skin test, the injection site is photographed at 0min after skin test, and vital signs are checked at 30min after skin…
Ting Huang, Master
…iochemistry, electrocardiogram, HIV antibody test and blood pregnancy test for women of childbearing age during the screening period.Vital signs were checked before skin test, the injection site was photographed at 0min after skin test, and vital signs were checked at 30min after…
Laniyati Hamijoyo, MD, PhD
…luding hepatitis B/C positivity, history of allergy to INH, pregnancy, malignancy * SLE patients who fulfil the inclusion criteria divided into two groups: Received INH 300 mg/day and Pyridoxine 10 mg/day for nine months or placebo. * Routine SLE medication continued and routinel…
Andrew DiNardo
…ion and exclusion criteria), will not receive study drug 4. Pregnancy test (within 24 hours prior to AZA dosing) PHASE IB: AZACITIDINE AFTER 10 WEEKS OF ATT; PRE-TREATMENT EVALUATION 1-Month pre-study drug: Recruitment, consent and completion of the Case Report Form (CRF) inclu…
Dr Vaneshree Govender
…ons between dolutegravir (DTG) and rifapentine (RPT) during pregnancy in people with HIV when RPT is given with isoniazid (INH) daily for 4 weeks (1HP) or weekly for 3 months (3HP) as part of tuberculosis (TB) preventive therapy (TPT). Adults (age ≥18) who are pregnant with a sin…
Lu Shuihua, Bachelor
…, electrocardiogram, chest CT, HIV antibody test, and blood pregnancy examination of women of childbearing age; Vital signs examination before the skin test, The injection site was photographed 0min after the skin test, Vital signs were performed 30min after the skin test; Vital …
Amita Gupta, MD, MHS
…in low-income settings. When TB occurs during or soon after pregnancy, it can cause complications for the mother as well as infant TB or death. Infant TB is very difficult to diagnose, and up to half of infant TB cases are caused by maternal TB. It has been shown that treatment f…
Mary Jane Rotheram-Borus, Ph.D.
…his study is to test a mother-to-mother intervention during pregnancy and after delivery with Mothers Living with HIV (MLH)in South Africa. We hypothesize that the intervention will enhance the adjustment of the children of MLH by improving the health and mental health of MLH whi…
Christina Yoon, MD
…vels) and the optimal timing of TPT initiation, relative to pregnancy (immediately during pregnancy or deferred to postpartum). Because undiagnosed TB among pregnant women with HIV is associated with many devastating complications to both the mother and fetus, this research has t…
University of Liverpool
… example during periods of rapid childhood growth or during pregnancy and transition back to non-pregnant physiological state. It is aimed to obtain 20 sparse PK profiles in each of the following groups (pregnant, child \<5, child 6-11, adolescent 12-18, obese (BMI \>30 Kg/m2), …
Giuseppe Pantaleo, MD
…2 dose regimen, 1 due to withdrawal of consent and 1 due to pregnancy \[the subject delivered a healthy boy without complications and was followed to study completion\]; and 1 in the AERAS-404 3 dose regimen, due to inability to discontinue daily isotretinoin started after the se…
Maryline Bonnet, MD, Nilesh Bhatt, MD
…-income countries, poor access to EFV, contradiction during pregnancy and absence of FDC containing EFV lead to difficulties in HIV-TB treatment. Despite 2 limited retrospective studies and a non-randomised prospective study, which report good virological response at 6 months in…
National Institute of Allergy and Infectious Diseases (NIAID)
…oing a physical exam and blood collection, and undergoing a pregnancy test for women of reproductive potential. Participants also will be required to keep a diary of the times they took outpatient study drugs, any medications taken other than the study drug, and any symptoms expe…
François Nosten, Professor
…me countries. However, there has been no sufficient data on pregnancy and people with co-morbidity especially HIV/TB patients. As there is limited knowledge about immunogenicity of COVID-19 vaccines among TB patients, examination of immunological responses from the COVID-19 vacc…
James Kublin, MD, MPH
…uations, blood draws, urine collections, skin biopsies, and pregnancy tests. This study will measure the rate of replication by utilizing qPCR and in vitro culture, systemic innate and adaptive immune responses, including humoral and cellular assay analyses and the evaluation and…