Showing 1–25 of 200 documents
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Heinke Kunst
…ptake is low. The issue of how best to screen for TB during pregnancy is important because pregnant/ postpartum women are at particularly high risk of developing TB, and migrants from countries with high TB rates may only interact with healthcare services during pregnancy. Effec…
Ji Qiao, MD.
…luate the effect of latent infection of tuberculosis on the pregnancy outcome of IVF-ET in infertile patients with radiographic lesions suggesting old healed tuberculosis China is one of the countries with high burden of tuberculosis (TB) defined by WHO. IVF-ET is an effective m…
Niaina RAKOTOSAMIMANANA, PhD
…ributor to maternal mortality in high-burden regions, TB in pregnancy is a hugely neglected area of global public health. During pregnancy, the symptoms of TB are often overlooked and undiagnosed because they are vague, non-specific, and can be very similar to common complaints d…
Ekaterina V Kurbatova, William C Whitworth, Kia E Bryant, Meredith G Dixon, Kelly E Dooley, et al.
…) treatment compared with the standard regimen. We analyzed pregnancy outcomes of women who became pregnant during the study. Among 740 women, 97 (13.1%) became pregnant. Of 102 pregnancies (in 97 participants), 30 (29.4%) participants were exposed to study drugs. Fetal loss…
Mark Mirochnick, MD
… (ARV) and anti-tuberculosis (TB) drugs administered during pregnancy and postpartum. This study will evaluate the pharmacokinetic (PK) properties of antiretroviral (ARV) and anti-tuberculosis (TB) drugs administered during pregnancy and postpartum. IMPAACT 2026 is a Phase IV o…
Grace Montepiedra, Lisa Aaron, Gerhard Theron, Katie McCarthy, Sarah Bradford, et al.
…eeks of isoniazid preventive therapy (IPT) initiated during pregnancy (immediate IPT) versus deferring to week 12 postpartum (deferred IPT) in people with HIV on antiretroviral therapy, showed higher than expected hepatotoxicity. We investigated the potential roles of antiretrovi…
PENTA Foundation
…trials of treatments and other interventions. The European Pregnancy and Paediatric Infections Cohort Collaboration (EPPICC) is an international network of researchers working together in this way. Researchers in the network represent cohort studies of pregnant women and childre…
Richard Chaisson, MD
Pregnant women who develop active Tuberculosis (TB) are at increased risk of poor maternal and infant outcomes. Our data from South Africa show that up to 3% of HIV-infected pregnant women have active TB , many with advanced disease, contributing to the 40% of maternal mortality …
Per Bjorkman, MD, PhD
…me countries are at elevated risk of death in connection to pregnancy, as well as infants born to women in such settings. It is probable that several factors are involved, such as poverty, lack of education and access to healthcare. Infectious diseases constitute important threat…
Per Bjorkman, MD, PhD
…of the placenta, and whether TB infection can contribute to pregnancy-related disorders through effects on the placenta. The main questions it aims to answer are: * Does TB infection affect the structure of the placenta? * Does TB infection affect the function of the placenta? …
Huashan Hospital
…ortant cause of female infertility in TB-endemic areas. The pregnancy rate of assisted reproductive treatment (ART) in the infertile women with FGTB is still unsatisfied even after receiving standard anti-tuberculosis treatment. Moreover, recent years have witnessed an alarming i…
Rosie Mngqibisa, MBChB, MPH, Susan E. Cohn, MD, MPH, Jennifer Robinson, MD, MPH
…e. In the setting of the treatment of active TB, preventing pregnancy becomes even more important because it allows women to attain a level of health that will support healthy future pregnancies. Treatment options for TB may be limited in pregnancy because of concerns about terat…
Helen McShane, MD and PhD
…y and only those who undertake to take precautions to avoid pregnancy during the study period will be eligible. Volunteers will give signed consent for their GP's to be notified about their participation in the trial. The GP will be faxed a letter on the day of screening and aske…
Helen McShane, MD and PhD
…y and only those who undertake to take precautions to avoid pregnancy during the study period will be eligible. Volunteers will give signed consent for their GP's to be notified about their participation in the trial. The GP will be faxed a letter on the day of screening and aske…
Helen McShane, MD and PhD
…y and only those who undertake to take precautions to avoid pregnancy during the study period will be eligible. Volunteers will give signed consent for their GP's to be notified about their participation in the trial. The GP will be faxed a letter on the day of screening and aske…
University of Colorado, Denver
…in to be aware if they are at greater risk of an unintended pregnancy while on the implant. An unintended pregnancy has many social, emotional, and financial impacts on women and society. Rifampin is also a Class C medication for pregnancy and could have potential negative effect…
Adrian Martineau, Prof
…. All women of childbearing age will be asked to do a urine pregnancy test before the PET-CT scan ; the scan will not proceed unless a negative pregnancy test result is obtained at this time. Blood samples (volume of 19 ml) for immunological testing and an induced sputum sample w…
Ting Huang, Master
…iochemistry, electrocardiogram, HIV antibody test and blood pregnancy test for women of childbearing age during the screening period.Vital signs were checked before skin test, the injection site was photographed at 0min after skin test, and vital signs were checked at 30min after…
Shuihua Lu, Bachelor, Hai Huang, Bachelor, Guan Liu, Master
…is culture, tuberculosis smear, HIV antibody test and blood pregnancy（only women of childbearing age） during the screening period.Vital signs were checked before skin test, the injection site is photographed at 0min after skin test, and vital signs are checked at 30min after skin…
Joseph A Kovacs, M.D.
…l history, physical exam, and blood tests. Women may have a pregnancy test. During the study, participants must: Use effective birth control Not take most medicine Not drink alcohol At the baseline visit, participants will repeat screening tests and get TAF tablets. Partici…
Laniyati Hamijoyo, MD, PhD
…luding hepatitis B/C positivity, history of allergy to INH, pregnancy, malignancy * SLE patients who fulfil the inclusion criteria divided into two groups: Received INH 300 mg/day and Pyridoxine 10 mg/day for nine months or placebo. * Routine SLE medication continued and routinel…
Andrew DiNardo
…ion and exclusion criteria), will not receive study drug 4. Pregnancy test (within 24 hours prior to AZA dosing) PHASE IB: AZACITIDINE AFTER 10 WEEKS OF ATT; PRE-TREATMENT EVALUATION 1-Month pre-study drug: Recruitment, consent and completion of the Case Report Form (CRF) inclu…
Huashan Hospital
… is relatively high in women with infertility and recurrent pregnancy loss. Whether preventive treatment of latent tuberculosis infection (LTBI) can improve the fertility outcome in women with recurrent implantation failure (RIF) remains to be explored. This is a prospective int…
Dr Vaneshree Govender
…ons between dolutegravir (DTG) and rifapentine (RPT) during pregnancy in people with HIV when RPT is given with isoniazid (INH) daily for 4 weeks (1HP) or weekly for 3 months (3HP) as part of tuberculosis (TB) preventive therapy (TPT). Adults (age ≥18) who are pregnant with a sin…
Thomas B Nutman, M.D.
…; women of childbearing potential will also undergo a urine pregnancy test, and those with positive test results will be excluded from the study. Individuals with positive PPD skin test results (\> or = 5 mm) and no symptoms of active TB will have their blood drawn (5 mL) as part…