Showing 1–25 of 41 documents
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Andrew Colin, MD, SM, Shatha Yousef, MD
…evalence of nontuberculous mycobacterial infection (NTM) in pediatric patients with cystic fibrosis in the State fo Florida. HYPOTHESIS: There is high prevalence of NTM in CF pediatric population in the State of Florida, and likely higher than in the rest of the country. Non-tub…
Hospices Civils de Lyon
…entation in areas of high incidence and low economic level. Pediatric cohorts in countries with high economic levels are rare, making it impossible to quantify and describe deviations from optimal recommendations. The French recommendations are mainly focused on screening cases o…
Awewura Kwara, MD
Lack of quality-assured pediatric formulations of the first-line antituberculosis (anti-TB) drugs is barrier to optimized tuberculosis (TB) treatment outcome in children. In 2010 and subsequently modified in 2014, the World Health Organization (WHO) recommended increased dosages …
Appolinaire Tiam, MBChB, MMed
…ategies will be compared: i) The standard of care, offering pediatric TB services based on current routine approach; ii) The intervention, with pediatric TB services integrated into child healthcare services. The primary objective will be to assess the effect of the intervention…
Morten Ruhwald, MD
…tra Sample Reagent. The second is a method developed by the Pediatric Asian African Network for Tuberculosis and HIV Research (PANTHER) group, the Optimized Sucrose Flotation method. Another diagnostic candidate, the urine Fujifilm SILVAMP TB LAM (FujiLAM) test will be assessed d…
Pontificia Universidad Catolica de Chile
The goal of this cluster-randomized controlled trial is to evaluate the effectiveness of tuberculosis preventive treatment (TPT) administered during the "window period" to prevent new Mycobacterium tuberculosis infections in children and adolescents. The main question it aims to…
Nicole Salazar-Austin, MD
…ts in low- and middle-income countries, with an emphasis on pediatric contacts. Although the aim of this policy is to find previously undetected TB patients and reduce transmission, such investigations represent a missed opportunity to start contacts without TB on preventive ther…
Nicole Salazar-Austin, MD
…on rates and therefore hold promise to reduce the 1 million pediatric TB patients and 233,000 child TB deaths annually. TPT effectiveness requires improvement in access to pediatric TB preventive care. The World Health Organization (WHO) estimates only 23% of the 1.3 million TB-e…
Stewart Reid, MD
…he first-line TB diagnostic test in HIV-infected adults and pediatric patients as a means to obtain faster, more accurate TB diagnosis. This study will evaluate Xpert Mycobacterium Tuberculosis/Rifampicin (MTB/RIF) as the first-line Tuberculosis (TB) diagnostic test in Human Imm…
Luckson Dullie, MBBS, M Fam Med, Elizabeth Dunbar, MPH, Emily Wroe, MD, MPH, Richard Lilford, Dsc, PhD, FRCOG, FRCP, FFPH, Celia Taylor, BSocSc (Hons), PhD, QTS, FHEA, et al.
…ge of conditions including HIV, hypertension, diabetes, and pediatric malnutrition. The new model is designed to improve retention in care for clients with chronic, non-communicable diseases, along with increased uptake of women's health services and treatment for pediatric malnu…
Boris Tchounga, MD, PHD, Daniel Atwine, MD, PhD
…study will be implemented under the frame of the Catalyzing Pediatric TB Innovation (CaP TB) Project, funded by Unitaid and implemented by the Elizabeth Glaser Pediatric AIDS Foundation (EGPAF). The goal of CaP TB is to improve the pediatric TB morbidity and mortality by catalyzi…
Alberto L García-Basteiro, MD, PhD, Elisa López Varela, MD, PhD
…nd PLHIV. * To create a biorepository of well characterized pediatric samples at each of the study sites to support the future development and evaluation of novel biomarker research. Methodology: This is a prospective diagnostic evaluation study with a nested longitudinal cohort…
Carolyn Bolton, MBBCh, Mutsawashe Bwakura-Dangarembizi, MD, Ellen Gould Chadwick, MD
…actors make EFV an attractive agent for use in HIV-infected pediatric patients with and without TB coinfection. This study will evaluate the safety, tolerance, and pharmacokinetics (PKs) of EFV when administered as opened capsules to pediatric patients younger than 3 years of age…
Roberto J Pires Neto
…spected tuberculosis hospitalized in the units of Adult and Pediatric Clinics and in the Critical Care Unit in a general hospital in Fortaleza-CE.
Holly Rawizza, MD, MPH
…rs to \<6 years. Children will be recruited from two large pediatric HIV clinics in Nigeria. Children in this study will receive HIV/TB cotreatment that is considered standard of care consisting of DTG twice daily during rifampicin (RIF)-containing TB treatment. For this portion…
Nicole Salazar-Austin, Silvia Cohn, Bareng A S Nonyane, Christiaan Mulder, Fiseha Mulatu, et al.
…TPT has the potential to substantially reduce the burden of pediatric TB in Ethiopia and elsewhere. **CLINICAL TRIALS REGISTRATION:** NCT04369326.
Worku Nigussa, MD
…, respectively, CAD software and stool Xpert MTB/RIF in the pediatric population and adult population are needed. The study will be carried out in at St. Luke Catholic Hospital, Wolisso, in Ethiopia. St. Luke Catholic Hospital is the referral Hospital in Southwest Shoa zone, Or…
Bahir Dar University
…ces. Informed consent for adult participants and assent for pediatrics participants will be obtained before data collection started. The purpose of the study will be communicated and permission will be obtained from the respected officials; the regional health bureau, respected z…
Michael Marmor
…nel. Natural history and impact on HIV disease in adult and pediatric populations were assessed by interviews, clinical screening and laboratory measures. Drug sensitivity testing and RFLP typing of specimens from the two populations were conducted, respectively, at the Bellevue …
Helen M McIlleron, PhD, Heather Zar, PhD
… when applying the 2010 WHO/IUATLD dosing guidelines across pediatric populations (0-12 years of age, HIV infected and uninfected, and with varied nutritional status) in Cape Town, South Africa and Blantyre, Malawi. 2. To evaluate an 8-hourly weight band-based dosing strategy for…
Olivier Marcy, MD, PhD, Maryline Bonnet, MD, PhD, Eric Wobudeya, MD, PhD
…eloped the PAANTHER algorithm. The ANRS 12229 PAANTHER 01 (Pediatric Asian African Network for Tuberculosis and HIV Research) study, which enrolled 438 HIV-infected children of median age 7.3 (IQR: 3.3 - 9.7) years with presumptive TB in four countries (Burkina Faso, Cameroon, C…
Léa DOMITIEN
…ations for prosthesis infections in adults. However, in the pediatric population, this type of infection is rarer and their management less well codified. The aim of this retrospective and descriptive monocentric study is to identify all osteoarticular infections in children und…
Greta L Becker, MD, Eric Wobudeya, MBChB, MMED, MSc
… whether this intervention can be feasibly implemented in a pediatric population in a low-resource context and to inform the design of a future randomized controlled trial.
Richard A. Oberhelman, MD
… evaluate novel approaches to the diagnosis of AIDS-related pediatric TB in a hyperendemic setting using rapid, cost-effective Mtb culture and susceptibility methods based on direct microscopic observation techniques. This study will utilize alternative noninvasive Mtb tests that…
National Taiwan University Hospital
…yopreserved donor aortic tissue patches to repair and treat pediatric patients with end-stage, life-threatening or severely disabling tracheal diseases who have not responded to conventional conservative therapies or lack sufficient native tracheal tissue for tracheal defect reco…