Showing 1–15 of 15 documents
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Helen Ayles, Professor
… PopART HIV-modelling to ensure a consistent account of HIV epidemiology. To facilitate this, the underlying demographic/HIV/ART structure (currently 81 age categories, 2 sexes, HIV-uninfected + 7 CD4 categories for PLHIV, and 4 ART durations) and the HIV/ART natural history para…
Jose JS Sifuentes -Osornio, Dr, Martha MT Torres-Rojas, DCs
Researchers will evaluate the efficacy, toxicity, adherence and cost effectiveness of treatment with isoniazid or rifampicin in patients with diabetes mellitus type two (DM2) and latent TB (LTB). This is a collaborative study with participation from three national institutes (In…
Queen Mary University of London
Tuberculosis (TB) is an infectious disease that is caused by bacteria (bugs). The infection is passed on when a patient with active lung TB coughs bugs into the air, which are then breathed in by an uninfected person. In 90% of people who get infected, the TB infection remains do…
Jaime Robledo, Dr
Introduction: childhood tuberculosis continues to be a major public health problem, despite the fact that the visibility of the epidemic in this population group has increased, studies are still lacking that can resolve the gaps that persist. Objective: To design, implement and …
Hospital Mutua de Terrassa
In countries with a low incidence of Tuberculosis (TB), the incidence remains higher among the immigrant population than among the autochthonous population beyond the first years after arrival in the host country. In addition, at a pediatric level, most cases are produced in immi…
Meyer Children's Hospital IRCCS
According to the WHO report of 2021, approximately 10 million new cases were reported in 2020, of which 1 million occurred in the pediatric population. However, epidemiological data available on tuberculosis (TB) in pediatric age are extremely limited due to diagnostic challenges…
Paola Dal Monte, MD
In the last 30 years, tuberculosis (TB) has re-emerged in industrialised countries as a public health, with a decrease in incidence among the resident population and an increase in the burden of immigrants. Therefore, it becomes a priority to implement an effective TB control tha…
Steven M Holland, M.D.
…ques has expanded our understanding of the pathogenesis and epidemiology of MTB. Identification of gene mutations that confer antibiotic resistance are being exploited as alternatives to conventional drug susceptibility testing. The natural history of all forms of TB disease (in…
PENTA Foundation
…ohorts within the same region are often similar in terms of epidemiology and treatment approaches), and region is then included as a covariate in the analysis. REGULATORY \& ETHICAL ISSUES COMPLIANCE EPPICC is an observational study with no study-specific interventions beyond th…
Linda Gail Bekker, MBChB, FCP, PhD, James McIntyre, MBChB, MRCOG
The purpose of this study is to determine the number of people infected with tuberculosis (TB) in the Masiphumelele Township of Cape Town, South Africa, a community with high rates of TB and HIV. This study will also examine the genetics of TB and the relationships among active T…
Tulane University
Pediatric tuberculosis (TB) continues to pose diagnostic challenges in low- and middle-income countries with high rates of TB disease, due to the well-described impact of paucibacillary disease in children, and current TB culture and polymerase-chain reaction tests are of limited…
Assistance Publique - Hôpitaux de Paris
…more, thorough knowledge of a specific country's TB disease epidemiology is essential to map out a comprehensive national strategic plan for TB and could help identify determinants for unfavorable treatment outcome or loss to follow-up. The healthcare pathway of patients with tub…
Archivel Farma S.L.
This study is proposed to evaluate the safety and efficacy of the RUTI vaccine in patients with pulmonary tuberculosis. Therapeutic vaccination of RUTI would stimulate the immune response not only against growing bacteria, but also against bacteria in a latent state that are less…
Dick Menzies, MD
Our study rationale is based on: 1. Tuberculosis Preventive Treatment (TPT) is given to healthy people and needs to be safe; 2. Tuberculosis Preventive Treatment (TPT) with shorter regimens are superior with respect to acceptance, completion, and costs; 3. 4 months of Rifampin 1…
Guislaine CARCELAIN, Dr
The accuracy of tuberculin skin test (TST) for detecting latent tuberculosis is limited in countries with a high proportion of population having received vaccination with the BCG. We aim to determine the cost-effectiveness of Quantiferon gold (QTFG), compared to BCG vaccine to de…