Showing 1–10 of 10 documents
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Sara Domínguez-Rodríguez, David Lora, Alfredo Tagarro, Cinta Moraleda, Álvaro Ballesteros, et al.
**BACKGROUND:** The EMPIRICAL trial aims to assess safety and efficacy of an empirical treatment against cytomegalovirus (CMV) and tuberculosis (TB) compared to standard of care (SoC), on adverse events and 15-day and 1-year mortality among infants living with HIV hospitalized wi…
Kate Rich, Ronelle Burger, Andrew Boulle, Deanne Goldberg, Noxolo Gqada, et al.
…B Check. **DESIGN:** The study was a randomised controlled trial with a parallel design. **SETTING:** This study assessed mHealth support to boost TB testing in high-burden Cape Town clinics. **INTERVENTION:** Patients aged 18 or above with a valid mobile phone number that had…
Pichanon Mingchay, Kamon Kawkitinarong, Pattama Torvorapanit, Pirapon June Ohata, Gompol Suwanpimolkul
… for presumed PTB. **METHODS:** In a randomized controlled trial at King Chulalongkorn Memorial Hospital, Thailand, 204 adults with presumed PTB and negative Xpert MTB/RIF Ultra results or inadequate sputum production were enrolled between July and October 2024. Participants wer…
Nazir Ismail, Harry Moultrie, Judith Mwansa-Kambafwile, Andrew Copas, Alane Izu, et al.
…his pragmatic, open-label, individual randomised controlled trial was done in nine clinics in Johannesburg, South Africa. Participants (aged ≥18 years) undergoing investigation for tuberculosis were randomly assigned (1:1) to the intervention group or control group (standa…
Bethou Adhisivam, Chinnathambi Kamalarathnam, B Vishnu Bhat, Kumutha Jayaraman, Siva P Namachivayam, et al.
… **DESIGN:** Multicentre, open label, randomised controlled trial SETTING: Three tertiary neonatal intensive care units (NICUs) in southeast India. **POPULATION:** Newborn babies weighing <2000 g. 7067 were assessed for eligibility and 5420 were randomised (2714 BCG-OPV, 2706 co…
Saskia Janssen, Thanakorn Vongjarudech, Mats O Karlsson, Caryn M Upton, Anthony J Garcia-Prats, et al.
…upporting broader access to the 3HP regimen. **PAN AFRICAN CLINICAL TRIALS REGISTRY:** PACTR202306775627089, registration date June 15, 2023.
Gavin Churchyard, MD, PhD, Bernard Landry, MPH
…as a Phase II, randomized, double-blind, placebo-controlled trial conducted at 1 site in South Africa. A total of 26 subjects were randomized 1:1 to receive 2 doses of either AERAS-402 at 3 x 10\^10 vp (N=13) or placebo (N=13) on Study Days 0 and 28. Dose-escalation to a second g…
Vanya Dhagat, MD
… tuberculosis infection. The study will be conducted at one clinical research site in India. The available live tuberculosis vaccine, Bacillus Calmette-Guérin (BCG), provides incomplete protection against pulmonary tuberculosis. For unknown reasons, a BCG revaccination or "boost…
Souleymane Mboup, Robert Wilkinson, Bernard Landry
…(immunogenicity analysis set). This Phase II multi-country trial was conducted as a randomized, double-blind, placebo-controlled trial in 650 HIV-positive adults with no evidence of active TB disease. Subjects were stratified at the time of randomization by whether or not they w…
Amadou T LY
…mple size, and recruitment strategies for a future efficacy trial of vaccine candidate MTBVAC in young children. MTBVAC is a new TB vaccine candidate based on an attenuated clinical isolate of M. tuberculosis. The clinical development consortium of this EDCTP program is preparin…