Showing 101–125 of 200 documents
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Heinke Kunst
The UK has the second highest tuberculosis (TB) incidence in Western Europe. Most active cases occur in migrants due to reactivation of latent TB infection (LTBI) acquired abroad. Screening migrants for LTBI was recently introduced by Public Health England to reduce TB rates and …
West China Hospital
Tuberculosis (TB) is a major and severe opportunistic infection among solid organ transplant recipients. Chemoprophylaxis is advised for those with latent tuberculosis infection (LTBI). However, the effectiveness of an isoniazid (INH) prophylactic approach based on TB risk factor…
Maunank Shah, MD, PhD
Latent Tuberculosis infection (LTBI) guidelines can be complex. LTBI-ASSIST is a web-based interactive tool to navigate US LTBI clinical practice guidelines in a patient-centered format that may guide clinical decision making around Latent TB care. The research goal is to determ…
Per Bjorkman, MD, PhD
…nt threats to maternal health in resource-limited settings. Tuberculosis (TB) is reported to be the third leading cause of maternal death globally. Furthermore, TB can be transmitted from mother to child during pregnancy, with high risk of severe consequences for the infant. Desp…
Daniel Bonnet, MD, France Mentre, PHD
…TB Gold In-Tube® and T-SPOT.TB® for the diagnosis of latent tuberculosis in HIV infected antiretroviral naive patients: 80 originated from low TB prevalence countries, without any active TB; 80 HIV infected antiretroviral naïve patients originated from high TB prevalence countrie…
Jean-Paul Janssens, M.D.
After exposure to an active case of tuberculosis (TB), close contacts may be infected. They are then considered as having latent tuberculosis infection (LTBI). Detecting LTBI is the main goal of contact tracing procedures after exposure to TB. Until recently, the only test availa…
Northwell Health
…nfection highly increases the risk of progression of latent tuberculosis (TB) to active disease that therapy is recommended for all PPD-positive, HIV-infected patients, regardless of age. Sensitivity of the PPD testing is, however, dependent on a normal T cell function. Therefor…
Ferenc Karpati, MD, PhD
…f this study is to vaccinate children suffering from latent tuberculosis against hepatitis B and to measure whether the immunization is related to specific interferon gamma response against Mycobacterium tuberculosis.
José Sifuentes, Doctor, Alfredo Ponce-de-León, Doctor, Maria de Lourdes García-García, Post doctor, Jose Luis Valdespino-Gómez, MD, Martha Torres Rojas, Post Doctor
…n immunodeficiency virus (positive VIH), to diagnose latent Tuberculosis, and to treat her with isoniazid for six months, measuring the production of Interferon range pre and posttreatment, to evaluate this way the result of the treatment on the immune response A descriptive ana…
Dereck Tait, MD, Angelique Luabeya, MD
…men-finding study in healthy adults with and without latent Tuberculosis (TB) Infection, who are Bacille Calmette Guerin (BCG)-vaccinated, HIV negative, and have no history or evidence of TB disease. The investigational product is AERAS-456 at 3 dose levels: 5, 15, and 50ug of H5…
Manjula Singh, Sindhu Joshi, Vikram Vohra, Rohit Sarin, Suchit Vasant Kamble, et al.
…ac in reducing the incidence of microbiologically confirmed tuberculosis (TB; pulmonary TB and extrapulmonary TB), development of latent TB infection, and immunogenicity. **DESIGN:** Phase 3 randomised clinical trial (PreVenTB trial). **SETTING:** 18 sites across six states of …
Miguel Santín
…r than with a 3-month (3HR) regimen for treatment of latent tuberculosis (TB) infection (LTBI) in patients with end stage kidney disease. Methods Design: Multicenter, prospective, parallel-group, open-label, controlled clinical trial. Study population: All adult patients with E…
François CREMIEUX
…ance of the 2nd generation TB-IGRA test in the diagnosis of tuberculosis. It is planned to include 500 patients. An enrolment of 455 subjects will enable us to demonstrate sensitivity-specificity levels of 92% for a 95% confidence interval and a 0.05 degree of precision. To take…
Yonsei University
… the health care workers who contact frequently with active tuberculosis patients have more increased prevalence of LTBI compared with those who don't.
Won-Jung Koh, M.D.
…n-r release assays (IGRAs) as diagnostic tool of the latent tuberculosis infection for healthcare workers.
Medical Director
…mpin. Rifampin is commonly used to treat people with latent tuberculosis infection (LTBI). The main goal of this study is to learn what happens to MK-8527 in the body over time when given with and without the medication rifampin in participants with LTBI.
Jang Won Shon, M.D., Ph.D.
The investigators aim to study the prevalence of latent tuberculosis infection (LTBI) using whole-blood interferon-r release assays, and determine the risk factors of LTBI in Korean health care workers. Further study details as provided by Hanyang University Hospital
Linda Gail Bekker, MBChB, FCP, PhD, James McIntyre, MBChB, MRCOG
…is study is to determine the number of people infected with tuberculosis (TB) in the Masiphumelele Township of Cape Town, South Africa, a community with high rates of TB and HIV. This study will also examine the genetics of TB and the relationships among active TB infection, new …
Jérémy Charriot, MD
…and their association in order to confirm or exclude active tuberculosis. Background : diagnostic methods to distinguish between latent TB infection (LTBI) and active TB disease remains challenging. Data are scarce concerning the positive predictive value of Current diagnostic a…
James Mancuso, MD MPH
…interferon-gamma release assays (IGRA) to screen for latent tuberculosis (TB) infection (LTBI) among military recruits. The current policy of universal application of the Mantoux tuberculin skin test (TST) to screen for LTBI may result in many TST reactions among recruits who are…
David Shitrit, MD
…res all health-care workers to undergo screening for latent Tuberculosis infection (LTBI) prior to starting work. This is based on the Mantoux skin test, which is notoriously unreliable. In recent years, more specific and sensitive tests based on interferon-gamma secretion to TB…
Jae-Joon Yim, MD
…itive conversion after exposure to smear positive pulmonary tuberculosis (TB) in a platoon of Korean military, a closed communal setting. In a platoon where TB outbreak occurred, we performed low dose chest CT (LDCT), QuantiFERON-TB gold in tube (QFT) and two-step (0, 4weeks) TS…
Valeria Saraceni, MD, Richard E Chaisson, M.D., Betina Durovni, M.D.
…cidence of active TB disease in the HIV clinic population. Tuberculosis remains a major public health problem in Brazil. Approximately 35% of HIV-infected adults in Rio de Janeiro are co-infected with latent TB. The Brazilian policies for the provision of treatment to HIV-infect…
Sang-cheol Bae, director
…red with those who receive only TST for detecting of Latent tuberculosis infection(LTBI) who are candidates of TNF inhibitors. Study Assessment 1. The positive rates of QFT-G and TST as a screening test for LTBI * The positive rates of QFT-G and TST will be analyzed * Ad…
Amar Safdar, MD
…OT.TB test and the conventional TST for screening of Latent Tuberculosis infections in patients with cancer and those undergoing Hematopoietic Stem Cell Transplant. Secondary Objectives: 1. To examine the factors associated with positive response to T-SPOT.TB and the TST (tuber…